DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tehao and IL1RAPL2

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_059112.1	Gene:	IL1RAPL2 / 26280	HGNCID:	5997	Length:	686	Species:	Homo sapiens

Alignment Length:	243	Identity:	56/243 - (23%)
Similarity:	116/243 - (47%)	Gaps:	31/243 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   565 DIADIVCTKQKKSFQQMEAFELCPS---YVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNN 626
            |:|:..|..:.::.::..:..|...   |.:.::..:|.:.:::.||.|.|..:..||.:: |..
Human   325 DLANYTCHVENRNGRKHASVLLRKKDLIYKIELAGGLGAIFLLLVLLVVIYKCYNIELMLF-YRQ 388

  Fly   627 NLCLWWVSEEELDKDKTYDAFISYSHKDEELIS-----------KLLPKLESGPHPFRLCLHDRD 680
            :    :.::|..|.:|.|||::||:..|::.:.           ::||.:....:.::|.:.:||
Human   389 H----FGADETNDDNKEYDAYLSYTKVDQDTLDCDNPEEEQFALEVLPDVLEKHYGYKLFIPERD 449

  Fly   681 WLVGDCIPEQIVRTVDDSKRVIIVLSQHFI-DSVWARMEFRIAYQATLQDKRKRIIIILYRELE- 743
            .:......|.:.|.|:.|:|:||||:..:| ...|:..|........|.....::|:|...||:
Human   450 LIPSGTYMEDLTRYVEQSRRLIIVLTPDYILRRGWSIFELESRLHNMLVSGEIKVILIECTELKG 514

  Fly   744 --HMNGIDSELRAYLKLNTYLKWG-------DPLFWSKLYYAMPHNRR 782
              :...::| |:..:||.:.:||.       :..||..|.|.||..::
Human   515 KVNCQEVES-LKRSIKLLSLIKWKGSKSSKLNSKFWKHLVYEMPIKKK 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380
		leucine-rich repeat	209..232	CDD:275380
		leucine-rich repeat	233..261	CDD:275380
		LRR_RI	<261..370	CDD:238064
		leucine-rich repeat	262..284	CDD:275380
		leucine-rich repeat	285..309	CDD:275380
		LRR_8	309..368	CDD:290566
		leucine-rich repeat	310..333	CDD:275380
		leucine-rich repeat	334..357	CDD:275380
		leucine-rich repeat	358..381	CDD:275380
		leucine-rich repeat	445..482	CDD:275380
		LRR_8	459..516	CDD:290566
		leucine-rich repeat	483..505	CDD:275380
		LRR_4	486..521	CDD:289563
		TIR	643..779	CDD:214587	39/157 (25%)
IL1RAPL2	NP_059112.1	Ig	32..133	CDD:325142
		Ig2_IL1R_like	146..237	CDD:319309
		IG_like	250..347	CDD:214653	3/21 (14%)
		TIR	402..563	CDD:307630	40/161 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8062
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860