DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and lron-5

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_497943.2	Gene:	lron-5 / 184307	WormBaseID:	WBGene00008656	Length:	656	Species:	Caenorhabditis elegans

Alignment Length:	595	Identity:	121/595 - (20%)
Similarity:	207/595 - (34%)	Gaps:	185/595 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 DVLNSGNGYMETSQPENITTWHFGSVPGLKKFKFFSHVPELQESIFHG----------------- 181
            :|::..|.::||..|..:.:..|..|..|...: .|::.:|...:..|
Worm    98 EVIDLSNNHLETLPPTVLRSLKFLRVLILSNNR-LSNLDQLTWILAPGVVLEQLDLSGNPIAIAT 161

  Fly   182 ----FDTLRDLHL------SVNVTT-----LPG-----------------NMLSTVN-GTLKTLT 213
                |..:|.|.|      |||.|.     |||                 ::::|:: .:.:.|.
Worm   162 SMTVFPPVRQLFLSDTRMESVNETAIMFKKLPGKCDRDVCRHIPIHNLNVSIITTIDFSSNRDLE 226

  Fly   214 IESPGIVSFGNPLLREL--------------QQLRNLSLALIH---PFHE--------------- 246
            |:|..:..|.|....:|              ::.|..||.:.|   |.||
Worm   227 IDSGALDVFSNATYVDLSNTRLPVGFEEWLERKSRVKSLNISHCQLPLHEDTWTACGQFLHSLDI 291

  Fly   247 ---------------------RDKQLQPHFFGSMTNLEEVRLASATSSVNRSMFK-------GTN 283
                                 ||..:...:..:: ::|.:.|       .|:||.       |..
Worm   292 SGIGAKRLRFSRFCPIRSVFARDNLISSVYIDAV-SMESLHL-------ERNMFSEFPIPPPGVE 348

  Fly   284 KLQLIKMNGNDDLM-ELPGEIFLDQVNLKTLDLSCNAIVTLHEDVFKGLG-NLTLLDLSKNRLTN 346
            ..:|..:..:.:|| .||........||:..|:|.|.:..:....|..:| .|..||||.|:|::
Worm   349 LTELHTLGLSHNLMTSLPPHALQSYPNLQHFDVSSNQLSEIDPQAFPSIGLGLISLDLSSNQLSS 413

  Fly   347 LSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLMNYEAVVCTNDEA 411
            |...|   |.||.:|.|:.|:::.:.|..|..:..|..:.:.:    ..||...     |.|.::
Worm   414 LPHPI---LPSLLLLDLSFNTISHLDPHFFTGLPMLQQLRIAS----NPTLFSR-----CPNRDS 466

  Fly   412 CQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLTSLPTVSE 476
                       |   ||             ...|:||     |:|:.  |.:.|:.|    ..|.
Worm   467 -----------P---CW-------------SDHLDEL-----TSLVD--LDISNSGL----EFSL 493

  Fly   477 HSGY-ANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSG 540
            |..: ..:..|.|..|.:..:.| ..||:||..||:..|::|..|:     ..:..:...|.:..
Worm   494 HWRHLRTLKSLILRGNEIRIIDS-KSLPENLRTLDLGENRVQFTSN-----FSKLEHLRDLRVDQ 552

  Fly   541 NPITCGCESLSLLFFVRTNPQRVRDIADIVCTKQKKSFQQMEAFELCPSYVLLISCVVGGLVIVI 605
            ||:.|.|....::..: .|..::.|.....|      |.....:.|.|....:..||........
Worm   553 NPLRCDCSLYDIVPHL-LNQSQISDPLLYYC------FSGSWQYPLLPYLASVKPCVDTTRNFYS 610

  Fly   606 CLLTVFYLMF 615
            .|:|.|.:.|
Worm   611 ILITTFIIAF 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	11/50 (22%)
		leucine-rich repeat	209..232	CDD:275380	6/36 (17%)
		leucine-rich repeat	233..261	CDD:275380	9/66 (14%)
		LRR_RI	<261..370	CDD:238064	33/117 (28%)
		leucine-rich repeat	262..284	CDD:275380	6/28 (21%)
		leucine-rich repeat	285..309	CDD:275380	5/24 (21%)
		LRR_8	309..368	CDD:290566	22/59 (37%)
		leucine-rich repeat	310..333	CDD:275380	6/23 (26%)
		leucine-rich repeat	334..357	CDD:275380	10/22 (45%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	445..482	CDD:275380	10/37 (27%)
		LRR_8	459..516	CDD:290566	16/57 (28%)
		leucine-rich repeat	483..505	CDD:275380	6/21 (29%)
		LRR_4	486..521	CDD:289563	12/34 (35%)
		TIR	643..779	CDD:214587
lron-5	NP_497943.2	leucine-rich repeat	51..72	CDD:275380
		LRR_8	72..131	CDD:338972	8/33 (24%)
		leucine-rich repeat	73..96	CDD:275380
		LRR	<92..>272	CDD:227223	33/174 (19%)
		leucine-rich repeat	97..120	CDD:275380	5/21 (24%)
		leucine-rich repeat	121..146	CDD:275380	5/25 (20%)
		leucine-rich repeat	147..168	CDD:275380	1/20 (5%)
		leucine-rich repeat	169..208	CDD:275380	10/38 (26%)
		leucine-rich repeat	209..237	CDD:275380	5/27 (19%)
		leucine-rich repeat	238..284	CDD:275380	8/45 (18%)
		leucine-rich repeat	327..351	CDD:275380	6/30 (20%)
		internalin_A	345..>576	CDD:380193	67/287 (23%)
		leucine-rich repeat	352..375	CDD:275380	5/22 (23%)
		leucine-rich repeat	376..391	CDD:275380	4/14 (29%)
		leucine-rich repeat	401..445	CDD:275380	17/46 (37%)
		leucine-rich repeat	446..478	CDD:275380	11/72 (15%)
		leucine-rich repeat	479..500	CDD:275380	6/26 (23%)
		leucine-rich repeat	501..522	CDD:275380	6/21 (29%)
		leucine-rich repeat	523..544	CDD:275380	6/25 (24%)
		LRRCT	553..601	CDD:214507	10/54 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910