DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tlr7

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001277687.1	Gene:	Tlr7 / 170743	MGIID:	2176882	Length:	1053	Species:	Mus musculus

Alignment Length:	970	Identity:	215/970 - (22%)
Similarity:	372/970 - (38%)	Gaps:	265/970 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GLSPQCTCAAEGNVVRFHCPDEYAMLLEVSEP-GASLYMSYYASTELQWLPRFNISSLVKIEF-- 94
            |||.......:||           .|||:.:. .:||::....:..:..:.:.|::.||.||.
Mouse   128 GLSDLKALYLDGN-----------QLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLY 181

  Fly    95 -------------------DAYIFWPE-KFLSDLLKTLGVQTVKT--------IIFRDRTLETVV 131
                               ||::.... |.||  ||...|..|.|        :...:..::.:.
Mouse   182 LGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLS--LKDNNVTAVPTTLPPNLLELYLYNNIIKKIQ 244

  Fly   132 TRDVLN---------SGN-------GY----METSQPENITTWHFGSVPGLKKFKFFS----HVP 172
            ..|..|         |||       .|    .|.:.|..|....|.|:..||..:..|    |||
Mouse   245 ENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVP 309

  Fly   173 ----------------------ELQESIF-HGFDTLRDLHLSVNV--------TTLPGNMLSTVN 206
                                  |::|:.| |....|.:|..|.|.        .|||.::.|..|
Mouse   310 PTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLEN 374

  Fly   207 GTLKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHPFHERD---------KQLQPHFFGSMTNL 262
              ||.|.::  |.|         .::|:|.||:::|.....:         |....:.|....||
Mouse   375 --LKILRVK--GYV---------FKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENL 426

  Fly   263 EEVRLA-----------------SATSSVNRSMFKGTNKLQLIKMNGNDDL--------MELPGE 302
            :.:.|:                 :|.:||:|   .|...|:.:.....|:.        .|.|..
Mouse   427 KLIDLSVNKISPSEESREVGFCPNAQTSVDR---HGPQVLEALHYFRYDEYARSCRFKNKEPPSF 488

  Fly   303 IFLD---QVNLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRL-TNLSSTIFAPLTSLNVLRL 363
            :.|:   .:..:|||||.|.|..:....|:.|..|..|:||.|.: ..|:.:...||..|..|..
Mouse   489 LPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDF 553

  Fly   364 NKNSLTAMSPSVFQDVVSLNYIEMVNTQFY----GATLLMNY-------EAVVCTNDEACQYKSA 417
            :.|.|..:..:.|:::.||..:::.:...|    |.|.::|:       :.::..:::.....|.
Mouse   554 SNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASR 618

  Fly   418 EWQCDPRCICWVQRSVGSL-IVDCRGTSLEEL--------PDLPRTTLLSTVLKVGNNSLTSLPT 473
            ..:.|            || |::.||..|:.|        .|..:......||.:..|||.|||.
Mouse   619 TMESD------------SLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPP 671

  Fly   474 VSEHSGYANVSGLFLSDNNLTSLG---------------SGDQL---PD-------NLTHLDVRG 513
            ........|:..|.|:.|.|.|..               |.:||   |:       :||.|.::.
Mouse   672 EVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKH 736

  Fly   514 NQIQSLSDEFL----------------LFLQEP-------NNTMTLSLSGNPITCGCESLSLLFF 555
            |||:.|:..||                ..:|:.       ||...|.|..|...|.|:::..:::
Mouse   737 NQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWW 801

  Fly   556 VRTNPQRVRDIA-DIVC----TKQKKSFQQMEAF--ELCPSYVLLISCVVGGLVIVICLLTVFYL 613
            |......:..:| |:.|    ..:.:|...::.:  ||..:.::|.|..:..::.::.::|..:|
Mouse   802 VNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTSHL 866

  Fly   614 MFQQELKIWLYNNNLCLWWVSE----EELDK-DKTYDAFISYSHKD----EELISKLLPKLESGP 669
            .|.....|:.:       |.::    :.|.. :..|||||.|..|:    |.::.:|:.|||. |
Mouse   867 FFWDMWYIYYF-------WKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLED-P 923

  Fly   670 HP--FRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRK 732
            ..  |.|||.:||||.|..:.|.:.:::..||:.:.|::|.:..:...:|.|.:::|..| |::.
Mouse   924 REKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLL-DEKV 987

  Fly   733 RIIIILYRELEHMNGIDSELRAYLKLNTYLKW-----GDPLFWSKLYYAMPHNRRVLKGQ 787
            .:||:::.|.........:||..|..::.|:|     ..|.||..|..|:..:..|...|
Mouse   988 DVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQ 1047

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	8/29 (28%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..261	CDD:275380	7/36 (19%)
		LRR_RI	<261..370	CDD:238064	34/137 (25%)
		leucine-rich repeat	262..284	CDD:275380	7/38 (18%)
		leucine-rich repeat	285..309	CDD:275380	5/34 (15%)
		LRR_8	309..368	CDD:290566	20/59 (34%)
		leucine-rich repeat	310..333	CDD:275380	9/22 (41%)
		leucine-rich repeat	334..357	CDD:275380	8/23 (35%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		leucine-rich repeat	445..482	CDD:275380	11/44 (25%)
		LRR_8	459..516	CDD:290566	22/81 (27%)
		leucine-rich repeat	483..505	CDD:275380	9/46 (20%)
		LRR_4	486..521	CDD:289563	16/59 (27%)
		TIR	643..779	CDD:214587	45/146 (31%)
Tlr7	NP_001277687.1	PRK15370	<35..>246	CDD:185268	25/130 (19%)
		leucine-rich repeat	51..72	CDD:275380
		leucine-rich repeat	73..93	CDD:275380
		leucine-rich repeat	94..131	CDD:275380	2/2 (100%)
		leucine-rich repeat	132..155	CDD:275380	7/33 (21%)
		PLN00113	177..>789	CDD:215061	138/641 (22%)
		leucine-rich repeat	177..208	CDD:275380	4/30 (13%)
		leucine-rich repeat	209..229	CDD:275380	8/21 (38%)
		leucine-rich repeat	230..253	CDD:275380	2/22 (9%)
		leucine-rich repeat	254..294	CDD:275380	9/39 (23%)
		leucine-rich repeat	295..318	CDD:275380	6/22 (27%)
		leucine-rich repeat	319..344	CDD:275380	4/24 (17%)
		leucine-rich repeat	345..401	CDD:275380	19/68 (28%)
		leucine-rich repeat	402..425	CDD:275380	2/22 (9%)
		leucine-rich repeat	500..522	CDD:275380	9/21 (43%)
		leucine-rich repeat	523..547	CDD:275380	8/23 (35%)
		leucine-rich repeat	548..571	CDD:275380	5/22 (23%)
		leucine-rich repeat	572..601	CDD:275380	5/28 (18%)
		leucine-rich repeat	602..624	CDD:275380	2/33 (6%)
		leucine-rich repeat	625..655	CDD:275380	7/29 (24%)
		leucine-rich repeat	656..680	CDD:275380	8/23 (35%)
		leucine-rich repeat	681..704	CDD:275380	5/22 (23%)
		leucine-rich repeat	705..728	CDD:275380	4/22 (18%)
		leucine-rich repeat	753..778	CDD:275380	1/24 (4%)
		PCC	757..>841	CDD:188093	15/83 (18%)
		TIR	894..1039	CDD:214587	45/146 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820