DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and Tlr3

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001344245.1	Gene:	Tlr3 / 142980	MGIID:	2156367	Length:	905	Species:	Mus musculus

Alignment Length:	684	Identity:	147/684 - (21%)
Similarity:	254/684 - (37%)	Gaps:	172/684 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 SVPGLKKFKF------------FSHVPELQESIFHGFDTLRDLHLSVNVTTLP----GNMLSTVN 206
            |.|.:..|.|            .:::|..:.:.|.|..:|:.|.||...|:|.    ...:|..:
Mouse   343 SHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAH 407

  Fly   207 GTLKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHPFHERDKQLQPHFFGSMTNLEEVRLASAT 271
            ..|.||.:....|....|.....|.|||.|.|.|    :|.:::|....:..:.|:.|:.|
Mouse   408 SPLLTLNLTKNHISKIANGTFSWLGQLRILDLGL----NEIEQKLSGQEWRGLRNIFEIYL---- 464

  Fly   272 SSVNRSMFKGTNKLQLIKMNGNDDLMELPG--EIFLDQVNLKTLDLSCNAIVTLHEDVFKGLGNL 334
             |.|:.:...|:...|:           |.  .:.|.:|.||.:|:|        ...|:.|.||
Mouse   465 -SYNKYLQLSTSSFALV-----------PSLQRLMLRRVALKNVDIS--------PSPFRPLRNL 509

  Fly   335 TLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLM 399
            |:||||.|.:.|::..:...|.:|.:|....|:|..:
Mouse   510 TILDLSNNNIANINEDLLEGLENLEILDFQHNNLARL---------------------------- 546

  Fly   400 NYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLLSTVLKVG 464
                                        |.:.:.|..:...:|.|...            :|.:.
Mouse   547 ----------------------------WKRANPGGPVNFLKGLSHLH------------ILNLE 571

  Fly   465 NNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLGS---GDQLPDNLTHLDVRGNQIQSLSDEFLLF 526
            :|.|..:| |........:..:.|..|||..|..   .||  .:|..|:::.|.|.|:..:  :|
Mouse   572 SNGLDEIP-VGVFKNLFELKSINLGLNNLNKLEPFIFDDQ--TSLRSLNLQKNLITSVEKD--VF 631

  Fly   527 LQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDIADI----VCTKQK-------KSFQQ 580
            .....|..:|.:..||..|.|||:|  :||....|...:|:::    :|....       |.|..
Mouse   632 GPPFQNLNSLDMRFNPFDCTCESIS--WFVNWINQTHTNISELSTHYLCNTPHHYYGFPLKLFDT 694

  Fly   581 MEAFELCPSYVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNLCLWW-------VSEEEL 638
            ....:..|..:|.|        |...:|.||.|:.   |.|.:....:..:|       :..:|:
Mouse   695 SSCKDSAPFELLFI--------ISTSMLLVFILVV---LLIHIEGWRISFYWNVSVHRILGFKEI 748

  Fly   639 D---KDKTYDAFISYSHKDEELISKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKR 700
            |   :...|.|:|.::|||.:.:.:....:|......:.||.:||:..|....|.||.::..|::
Mouse   749 DTQAEQFEYTAYIIHAHKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRK 813

  Fly   701 VIIVLSQHFI-DSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDSEL-------RAYLK 757
            :|.|::.|.: |.:..|.:...|.|..::.....||:|..:.:.     |.:|       |...|
Mouse   814 IIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNIP-----DYKLNHALCLRRGMFK 873

  Fly   758 LNTYLKWGDPLFWSKLYYAMPHNRRVLKGQKKHA 791
            .:..|.|  |:...:: .|..|..:|..|.:..|
Mouse   874 SHCILNW--PVQKERI-NAFHHKLQVALGSRNSA 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	7/25 (28%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		leucine-rich repeat	233..261	CDD:275380	7/27 (26%)
		LRR_RI	<261..370	CDD:238064	30/110 (27%)
		leucine-rich repeat	262..284	CDD:275380	5/21 (24%)
		leucine-rich repeat	285..309	CDD:275380	3/25 (12%)
		LRR_8	309..368	CDD:290566	19/58 (33%)
		leucine-rich repeat	310..333	CDD:275380	6/22 (27%)
		leucine-rich repeat	334..357	CDD:275380	9/22 (41%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	445..482	CDD:275380	5/36 (14%)
		LRR_8	459..516	CDD:290566	15/59 (25%)
		leucine-rich repeat	483..505	CDD:275380	7/24 (29%)
		LRR_4	486..521	CDD:289563	12/37 (32%)
		TIR	643..779	CDD:214587	34/143 (24%)
Tlr3	NP_001344245.1	leucine-rich repeat	37..53	CDD:275380
		LRR 1	53..74
		leucine-rich repeat	54..77	CDD:275380
		PLN00113	70..>543	CDD:215061	57/227 (25%)
		LRR 2	77..98
		leucine-rich repeat	78..101	CDD:275380
		LRR 3	101..122
		leucine-rich repeat	102..125	CDD:275380
		LRR 4	125..146
		leucine-rich repeat	126..149	CDD:275380
		LRR 5	149..170
		leucine-rich repeat	150..199	CDD:275380
		LRR 6	173..196
		LRR 7	199..220
		leucine-rich repeat	200..250	CDD:275380
		LRR 8	250..271
		leucine-rich repeat	251..276	CDD:275380
		LRR 9	276..297
		leucine-rich repeat	277..300	CDD:275380
		LRR 10	300..321
		leucine-rich repeat	301..324	CDD:275380
		LRR 11	324..345		1/1 (100%)
		leucine-rich repeat	325..381	CDD:275380	7/37 (19%)
		LRR 12	357..378		2/20 (10%)
		LRR 13	381..401		6/19 (32%)
		leucine-rich repeat	382..433	CDD:275380	13/50 (26%)
		LRR 14	409..430		5/20 (25%)
		LRR 15	433..454		8/24 (33%)
		leucine-rich repeat	434..458	CDD:275380	7/27 (26%)
		LRR 16	458..479		6/25 (24%)
		leucine-rich repeat	459..482	CDD:275380	6/38 (16%)
		LRR 17	482..502		6/27 (22%)
		leucine-rich repeat	483..508	CDD:275380	8/32 (25%)
		PPP1R42	503..>649	CDD:411060	42/218 (19%)
		LRR 18	508..529		9/20 (45%)
		leucine-rich repeat	509..532	CDD:275380	9/22 (41%)
		LRR 19	532..553		5/76 (7%)
		leucine-rich repeat	533..564	CDD:275380	7/86 (8%)
		LRR 20	564..585		5/33 (15%)
		leucine-rich repeat	565..586	CDD:275380	5/33 (15%)
		LRR 21	588..609		5/20 (25%)
		leucine-rich repeat	589..610	CDD:275378	5/20 (25%)
		LRR 22	612..633		6/22 (27%)
		leucine-rich repeat	613..637	CDD:275380	6/25 (24%)
		LRRCT	646..698	CDD:214507	14/53 (26%)
		Tlr3_TMD	699..731	CDD:407816	10/42 (24%)
		TIR	756..901	CDD:214587	37/152 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920