DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tehao and LOC103911657

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_009303036.2	Gene:	LOC103911657 / 103911657	-ID:	-	Length:	951	Species:	Danio rerio

Alignment Length:	898	Identity:	210/898 - (23%)
Similarity:	342/898 - (38%)	Gaps:	233/898 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 FALLVLRSATGQIIP------LPTFCLGLSPQCTCAAEGNVVRFHCPDEYAMLLEVSEPGASLYM 70
            ::|.:|.|...:.||      |...||....:..|.........|...:..:|..:..|..|::.
Zfish   157 YSLSLLASNVFETIPLLQNLILANVCLRDMSEVLCRLSKVKTLKHFTLKEFLLKRLQYPNCSVFN 221

  Fly    71 SYYASTELQWLPRFNISSL--------------VKI--EFDAYIFWPEK--FLSDLLKTLGVQTV 117
            :...|||      |||..:              :|:  :...::|....  ||.| |..:||..:
Zfish   222 TSDISTE------FNIEEVNLHFATVEHVDEGALKVFGKLSRFVFSVSSTDFLRD-LSLIGVHKI 279

  Fly   118 KTIIFRDRTLETVVTRDVLNSGNGY-METSQPENITT--W--HFGSVPGLKKFKFFSHVPELQES 177
            ||:.|:   ::.:...|:..:...| :.:.|.:..||  |  |.....|.|..|
Zfish   280 KTLDFK---VDLLNVADLCTAAKLYGINSIQVKYKTTNFWPTHTNISGGCKNIK----------- 330

  Fly   178 IFHGFDTLRDLHLSVNVTTLPGNML--STVNGTLKTLTIESPGIVSFGNPLLRE----------- 229
                 |.:.|..|      .|.|:|  :.|......||     |:|....:||.
Zfish   331 -----DVMLDTIL------YPANLLDVNCVFQIFSNLT-----IISIYKHVLRSDDFQTLCASFP 379

  Fly   230 --LQQLRNLSLALIHPFHERDKQLQPHFFGSMTNLEEVRLASATSSVNRSM-FKGTNKLQLIKMN 291
              ::.|..:.|.|     ::...:..|.|....|||.:...|:...|.... |.|.||
Zfish   380 QTVKHLSAMDLRL-----KKVDTIVSHQFMCFPNLETLIFTSSKIVVIEDFAFIGLNK------- 432

  Fly   292 GNDDLMELPGEIFLDQVNLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKN-----------RLT 345
                              ||.|:|..|.|.::|...|.||..|.:|||.:|           ..|
Zfish   433 ------------------LKELNLRKNKISSIHRHTFSGLHELLVLDLQENPIIYIEPKSFGHFT 479

  Fly   346 NLSSTIFAPLT---SLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLMN------- 400
            ||||.:...|.   ::::::|:.:.:....||...:|...:.:..::......|.|.|
Zfish   480 NLSSLLLGDLNFPPNMSLIKLHLSDIFGGIPSNLSNVFISSGLRPMHLMIGSNTTLNNGLNLHIK 544

  Fly   401 --------YEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLL 457
                    ..:::.|:....|..:|...|:...|.....||.||  :.:....:.:.||.....|
Zfish   545 GQYVIVEDCNSLLLTSVVKLQIHAAYMSCENDFIGKYVPSVVSL--EFQSMFSDNIGDLSVINQL 607

  Fly   458 --STVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSL--------------GSGDQLPDNL 506
              ...||:.|...|:.|         |...:|   :|||.|              ||..:....|
Zfish   608 FHLKTLKLRNIEFTNQP---------NTGIMF---HNLTKLETLILSNCRIFFLDGSLTKDLKAL 660

  Fly   507 THLDVRG----NQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDIA 567
            |.|.:..    |.:||.. |.|:.|:      .:.:....:.|.|::..|..:|:.|    |.:.
Zfish   661 TKLLLSAKHTVNILQSFV-EHLVHLE------YIHIDSIDLYCSCDNAWLFSWVKDN----RKVE 714

  Fly   568 DIVCTKQKKSFQQMEAF---------------ELC---PSYVLLISCVVGGLVIVICLLTVFYLM 614
            .:|   ...|.|.::.|               |.|   ..:||..|..|     .:|:..|..||
Zfish   715 VVV---SNPSMQNLQCFIGNEFDQLNFVSYVKENCLFDLDFVLFTSTSV-----FLCIFIVVVLM 771

  Fly   615 FQ---QELKIWLYNNNLCLWWVSEEELDKDK---TYDAFISYSHKDEE-LISKLLPKLES-GPHP 671
            :.   |.||.:.:..|   .|..|....|:|   .||||:|||.|||. :|.:|||.||. ||..
Zfish   772 YNFVGQYLKPFYHIAN---GWFREALRMKEKQQYRYDAFVSYSGKDEHWVIEELLPNLEQRGPPF 833

  Fly   672 FRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIA-YQATLQDKRKRII 735
            .|||||.||:.:|..|.|.|..::..|:|.:.::|:::::|.|..:|.::| |:  ||.:.:.|:
Zfish   834 LRLCLHSRDFQLGHDIVENITDSIYASRRTLCLVSRNYLNSNWCSLEMQLATYR--LQVEHRDIL 896

  Fly   736 IILYRELEHMNGIDS--ELRAYLKLNTYLKW-GDP----LFWSKLYYAMPHNR 781
            |:::.|......:.|  .|...:|..|||.. .:|    .||.:|:..:..|:
Zfish   897 ILVFLETIPSCLLSSHHRLARLVKTRTYLDCPQEPEMHDAFWDRLWCKLSSNK 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	6/23 (26%)
		leucine-rich repeat	209..232	CDD:275380	6/35 (17%)
		leucine-rich repeat	233..261	CDD:275380	5/27 (19%)
		LRR_RI	<261..370	CDD:238064	31/123 (25%)
		leucine-rich repeat	262..284	CDD:275380	6/22 (27%)
		leucine-rich repeat	285..309	CDD:275380	0/23 (0%)
		LRR_8	309..368	CDD:290566	22/72 (31%)
		leucine-rich repeat	310..333	CDD:275380	10/22 (45%)
		leucine-rich repeat	334..357	CDD:275380	11/36 (31%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	445..482	CDD:275380	8/38 (21%)
		LRR_8	459..516	CDD:290566	17/74 (23%)
		leucine-rich repeat	483..505	CDD:275380	7/35 (20%)
		LRR_4	486..521	CDD:289563	13/52 (25%)
		TIR	643..779	CDD:214587	52/145 (36%)
LOC103911657	XP_009303036.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920