DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tehao and TLR6

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001381482.1	Gene:	TLR6 / 10333	HGNCID:	16711	Length:	796	Species:	Homo sapiens

Alignment Length:	794	Identity:	176/794 - (22%)
Similarity:	300/794 - (37%)	Gaps:	215/794 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 CAAEGNVVRFHCPDEYAMLLEVSE--PGASLYMS---------YYASTELQWLPRFNISSLVKIE 93
            |...||:.:.:.....||.|:..:  |.|.|::|         |....|.:.|...|..:|..:.
Human   139 CKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVF 203

  Fly    94 FDAYIFWPEKFLSDLLKTLGVQTVKTIIFRDRTLETVV------TR--DVLNSGNGYMETSQPEN 150
            ....:|..:..:|  :.|||...:..|...|...:..:      ||  .:||....::|
Human   204 HPTSLFAIQVNIS--VNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIE------ 260

  Fly   151 ITTWHFGSVPGLKKFKFFSHVPELQESIFH--GFDTLRDLHLSVNVTTLPGNMLSTVNGTLKTLT 213
             |||..    .::.|:|....|....:|::  ..:::|:...:.:.|            |||.||
Human   261 -TTWKC----LVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKT------------TLKALT 308

  Fly   214 IE--SPGIVSFGNPLLRELQQLRNLSLALIH--PF-HERDKQLQPHFFGSMTNLEEVRLASATSS 273
            ||  :..:..|....|..:....|:.:..|.  || |    .|.||...:.      :..:.|.:
Human   309 IEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIH----MLCPHAPSTF------KFLNFTQN 363

  Fly   274 V-NRSMFKGTN---KLQ--LIKMNGNDDLMELPGEIFLDQVNLKTLDLSCNAIVT-LHEDVFKGL 331
            | ..|:|:..:   ||:  :::.||..||.:: |.:..|..:|:.||:|.|::.: .|::....:
Human   364 VFTDSIFEKCSTLVKLETLILQKNGLKDLFKV-GLMTKDMPSLEILDVSWNSLESGRHKENCTWV 427

  Fly   332 GNLTLLDLSKNRLTNLSSTIFAPL-TSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGA 395
            .::.:|:||.|.||:   ::|..| ..:.||.|:.|.:    .||.:.||.|..::.:|..|
Human   428 ESIVVLNLSSNMLTD---SVFRCLPPRIKVLDLHSNKI----KSVPKQVVKLEALQELNVAF--- 482

  Fly   396 TLLMNYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLLSTV 460

Human   483 ----------------------------------------------------------------- 482

  Fly   461 LKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLL 525
                 ||||.||.....|..:    :.:.|:|..|..|.|
Human   483 -----NSLTDLPGCGSFSSLS----VLIIDHNSVSHPSAD------------------------- 513

  Fly   526 FLQEPNNTMTLSLSGNPITCGCESLSLLFFVRTNPQRVRDI---------ADIVCTKQKKSFQQM 581
            |.|......::....||..|.||   |..||:...|...::         .|...:.:....:..
Human   514 FFQSCQKMRSIKAGDNPFQCTCE---LREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDF 575

  Fly   582 EAFELCPSYVLLISCVVGGLVIVICLLTVFYLMFQQELKIWLYNNNLCLWW--------VSEEEL 638
            ...||..:..|||  |..|..:::..:||..|....:|. | |...:|.|.        :..|||
Human   576 HMSELSCNITLLI--VTIGATMLVLAVTVTSLCIYLDLP-W-YLRMVCQWTQTRRRARNIPLEEL 636

  Fly   639 DKDKTYDAFISYSHKDEELI-SKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVI 702
            .::..:.||||||..|...: |:|:|.||.  ...::|||:|:::.|..|.|.|:..::.|.:.|
Human   637 QRNLQFHAFISYSEHDSAWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIINCIEKSYKSI 699

  Fly   703 IVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMNGIDS---ELRAYLKLNTYLKW 764
            .|||.:|:.|.|...|...|:.....:....:|:||...:. .|.|.:   :|:|.:...|||:|
Human   700 FVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIP-QNSIPNKYHKLKALMTQRTYLQW 763

  Fly   765 GDP-----LFWSKL 773
            ...     |||:.:
Human   764 PKEKSKRGLFWANI 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	2/21 (10%)
		leucine-rich repeat	209..232	CDD:275380	8/24 (33%)
		leucine-rich repeat	233..261	CDD:275380	8/30 (27%)
		LRR_RI	<261..370	CDD:238064	30/116 (26%)
		leucine-rich repeat	262..284	CDD:275380	4/25 (16%)
		leucine-rich repeat	285..309	CDD:275380	7/25 (28%)
		LRR_8	309..368	CDD:290566	18/60 (30%)
		leucine-rich repeat	310..333	CDD:275380	6/23 (26%)
		leucine-rich repeat	334..357	CDD:275380	8/23 (35%)
		leucine-rich repeat	358..381	CDD:275380	7/22 (32%)
		leucine-rich repeat	445..482	CDD:275380	7/36 (19%)
		LRR_8	459..516	CDD:290566	12/56 (21%)
		leucine-rich repeat	483..505	CDD:275380	5/21 (24%)
		LRR_4	486..521	CDD:289563	5/34 (15%)
		TIR	643..779	CDD:214587	44/140 (31%)
TLR6	NP_001381482.1	LRR 1	54..77
		LRR 2	78..101
		LRR 3	102..122
		LRR 4	123..147		3/7 (43%)
		LRR 5	148..168		4/19 (21%)
		LRR 6	169..196		5/26 (19%)
		LRR 7	197..219		3/23 (13%)
		LRR 8	220..250		6/29 (21%)
		LRR 9	251..277		8/36 (22%)
		LRR 10	278..303		3/36 (8%)
		LRR 11	304..330		8/25 (32%)
		LRR 12	331..354		8/26 (31%)
		LRR 13	355..378		4/28 (14%)
		LRR 14	379..404		7/25 (28%)
		LRR 15	405..429		6/23 (26%)
		LRR 16	430..450		8/22 (36%)
		LRR 17	451..474		9/26 (35%)
		LRR 18	475..496		8/93 (9%)
		LRR 19	497..520		7/51 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920