DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tehao and cd180

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	NP_001297419.1	Gene:	cd180 / 101885327	ZFINID:	ZDB-GENE-070705-323	Length:	665	Species:	Danio rerio

Alignment Length:	518	Identity:	129/518 - (24%)
Similarity:	206/518 - (39%)	Gaps:	166/518 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 EPGA--SLYMSYYASTELQ-WLPRFNISSLVK--------------IEFDAYIFWPEKFLSDLLK 110
            ||||  ||.:|   |.:.. .|.:.|||||:|              .|.|:.::         :.
Zfish   217 EPGAFHSLNLS---SLDFSGCLNKMNISSLLKGLEGIKTNRLNLGLYETDSNVY---------IA 269

  Fly   111 TLGVQTVKTIIFRDRTLETVVTRDVLNSGNGYMETSQPENITTWHFGSVP----GLKKFKFFSHV 171
            :..:|:...|...|...:.....|:.||....:|..:..::|..|..::|    ||..   .||:
Zfish   270 SAALQSFCNIFVSDLDFQLQHFLDLNNSTFHCLEGLKKLDLTRAHLNALPLNTTGLST---LSHL 331

  Fly   172 PELQESIFHGFDTLRDLHLSVNVTTLPGNMLS--TVNGTLKTLTIESPGIVSFGNPLLRELQQLR 234
             .|.|:.|      :|:..| |....|  ||:  :::|.||.||..:..:.|.|  ||.||
Zfish   332 -ILDENQF------KDVCQS-NTRNFP--MLTHLSISGNLKKLTFSNRCLDSLG--LLEEL---- 380

  Fly   235 NLSLALIHP---------FHERDKQL------QPHFFGS-------------------------- 258
            :||::|::|         |...:.:|      .|.|:.|
Zfish   381 DLSVSLVNPREPCCNNQLFGLGELKLLNLSYGSPMFWSSKPFNVTPKLEHLDFSHSVYTLLNDSS 445

  Fly   259 -MTNLEEVRLA----SATSSVNRSMFKGTNKLQLIKMNGNDDLMELPGEIFLDQVN-------LK 311
             .:||:.:|..    |.|...|..:|.|...||.:.:.||    .:.||: |.|..       |:
Zfish   446 PFSNLQSLRTLNLSWSNTDLTNVHLFVGLKALQHLNLRGN----AIQGEV-LTQTELFKCVPLLE 505

  Fly   312 TLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLN--KNSLTAMSPS 374
            ||.||...|.:..|::||||.:|..:|||:|:...||::.|   .||:.|:||  :|.:|.:..:
Zfish   506 TLVLSACKITSFDENLFKGLRHLNHIDLSENKFVKLSTSGF---YSLDFLKLNFARNDITTVDVA 567

  Fly   375 VFQDV-----VSLNYIEMVNTQFYGATLLMNYEAVVCTNDEACQYKSAEWQCDPRCICWVQRS-- 432
            ...|:     |.|:|..:|..               |:|.|              .|.||:::
Zfish   568 SVADLGEEGSVDLSYNPLVCN---------------CSNFE--------------FIHWVKKNKV 603

  Fly   433 -VGSLI-VDCRGTSLEELP-----DLPRTTL-----LSTVLKVGNNSLTSLPTVSEHSGYANV 483
             |..|: ..|.||....:.     |||...|     |:.|| :.:.....:..|.::|.|.|:
Zfish   604 KVKHLMETFCNGTGTRIIDAKLQCDLPVGVLVFCAVLAAVL-LASAIFLLIRRVRKYSIYTNL 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	6/23 (26%)
		leucine-rich repeat	209..232	CDD:275380	10/22 (45%)
		leucine-rich repeat	233..261	CDD:275380	9/69 (13%)
		LRR_RI	<261..370	CDD:238064	41/121 (34%)
		leucine-rich repeat	262..284	CDD:275380	7/25 (28%)
		leucine-rich repeat	285..309	CDD:275380	8/23 (35%)
		LRR_8	309..368	CDD:290566	25/67 (37%)
		leucine-rich repeat	310..333	CDD:275380	11/22 (50%)
		leucine-rich repeat	334..357	CDD:275380	8/22 (36%)
		leucine-rich repeat	358..381	CDD:275380	7/29 (24%)
		leucine-rich repeat	445..482	CDD:275380	10/46 (22%)
		LRR_8	459..516	CDD:290566	6/25 (24%)
		leucine-rich repeat	483..505	CDD:275380	0/1 (0%)
		LRR_4	486..521	CDD:289563
		TIR	643..779	CDD:214587
cd180	NP_001297419.1	leucine-rich repeat	40..56	CDD:275380
		LRR_8	56..115	CDD:316378
		leucine-rich repeat	57..80	CDD:275380
		leucine-rich repeat	81..104	CDD:275380
		LRR_8	103..163	CDD:316378
		leucine-rich repeat	105..128	CDD:275380
		leucine-rich repeat	153..176	CDD:275380
		leucine-rich repeat	177..200	CDD:275380
		leucine-rich repeat	201..225	CDD:275380	5/7 (71%)
		leucine-rich repeat	226..247	CDD:275380	9/23 (39%)
		leucine-rich repeat	284..304	CDD:275378	3/19 (16%)
		leucine-rich repeat	305..327	CDD:275380	5/21 (24%)
		leucine-rich repeat	328..351	CDD:275380	9/32 (28%)
		leucine-rich repeat	352..376	CDD:275380	8/25 (32%)
		leucine-rich repeat	404..427	CDD:275380	4/22 (18%)
		LRR_8	426..487	CDD:316378	12/64 (19%)
		leucine-rich repeat	428..452	CDD:275380	2/23 (9%)
		leucine-rich repeat	453..476	CDD:275380	6/22 (27%)
		leucine-rich repeat	477..503	CDD:275380	8/30 (27%)
		LRR_8	502..561	CDD:316378	25/61 (41%)
		leucine-rich repeat	504..527	CDD:275380	11/22 (50%)
		leucine-rich repeat	528..549	CDD:275380	8/23 (35%)
		leucine-rich repeat	552..574	CDD:275380	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25481
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820