DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and tlr7

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_021334735.1	Gene:	tlr7 / 100534776	ZFINID:	ZDB-GENE-040219-11	Length:	1036	Species:	Danio rerio

Alignment Length:	809	Identity:	187/809 - (23%)
Similarity:	308/809 - (38%)	Gaps:	244/809 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 YMETSQPENITTWHFGSVPGLKKFKFFSHVPELQESIF---------------HGFDTLRDLHL- 190
            |:..:..|.||...|.::..|:......:.|....:.|               :.|.|||:|..
Zfish   223 YLYNNNIEKITENDFCNLTELEVLDLSGNCPRCYNAPFPCIPCPNNAPLQIHPNSFKTLRNLKTL 287

  Fly   191 ---SVNVTTLPGNMLSTV----------NGTLKTLTIES-PGIVSFGNPLLRELQ-------QLR 234
               |.::|.:|.....::          |...|.:|..| |.::    |.|.||.       |:.
Zfish   288 RLHSNSLTNIPPEWFQSLADLTLLDLSSNFLAKEITCTSFPSLL----PKLEELDLSFNYELQVY 348

  Fly   235 NLSLALIHPFHE----RDKQLQPHFFGSMTNLEEVRLASATSSVNRSMFK----GTN-----KLQ 286
            ..||:|...|.:    |..:::.:.|      :|::|.......|.:..:    |||     :|.
Zfish   349 PASLSLSESFSQLKSLRVLRIRGYVF------QELKLQDIQPLTNLTYLEFLDLGTNFIKIAQLS 407

  Fly   287 LIK-------MNGNDDLMELP---------------------------GEI-----FL-DQVNL- 310
            ::|       :|.:|:.:.:|                           ||:     || |:...
Zfish   408 ILKNLKNFKIINLSDNKISVPSEGEFSFSNHREAYYGSPMSQGAQYHNGEVKDMHYFLYDEFARS 472

  Fly   311 ----------------------KTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLT-NLSSTIF 352
                                  ||||:|.|.|..||.. |..||.|..|:||.|.:: :|:.:.|
Zfish   473 CKYKDKELWIPSPFNNDCSSFGKTLDISRNNIFFLHSK-FLNLGELRCLNLSGNAMSQSLNGSEF 536

  Fly   353 APLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFY----GATLLMNY------------ 401
            ..||:|..|....|.|..|.||.||::.:|..:::.....|    |.|.::|:
Zfish   537 VQLTNLQYLDFTDNRLDLMYPSAFQELSNLVVLDISRNSHYFVAEGLTHMLNFTENLSKLRKLIM 601

  Fly   402 ---EAVVCTNDEACQYKSAE-----------WQ-CDPRCICWVQRSVGSLIVDCRGTSLEELP-- 449
               :....||.|...||...           |: .|.|.:.:.:..:....:|....:|..:|
Zfish   602 NDNQISTSTNTEMKSYKLEHLEFKGNRLDMLWRDGDTRYVNYFKNLMSLKTLDISRNNLNFIPLV 666

  Fly   450 ---DLPRT-----------------------TLLSTVLKVGNNSLTSLPTVSEHSGYA-NVSGLF 487
               .||.|                       :||  :|.:..|.||.:|:..  |.|. ::..|.
Zfish   667 VFQGLPNTLTKLYITDNKLKLFKWEGLVYLKSLL--LLDLTGNLLTEVPSCL--SNYTKSIQTLV 727

  Fly   488 LSDNNLTSLGSGDQLPD--NLTHLDVRGNQIQSLSDEFLLFLQE---PNNTM----TLSLSGNPI 543
            ||.|.:..| |.:.|.|  :|..||:..|.||        |:.|   |.|.:    ||.|:.|..
Zfish   728 LSKNKIVKL-SPNFLKDAFSLKILDLSYNSIQ--------FIDESSFPENVIDHLQTLYLNNNMF 783

  Fly   544 TCGCESLSLLFFV-RTNPQRVRDIADIVCTKQKKSFQQMEAFELCPSYVLLISCVVGGLVIVIC- 606
            .|.|.:..|:.:: ||:....|..:|:.|........|...|      :.|.:|....|.|::|
Zfish   784 VCSCNATWLVRWINRTSVNIPRLASDVTCASPSAQKGQSVIF------LNLQACQHNSLSIILCI 842

  Fly   607 -----LLTVFYLMFQQELKIWLYNNNLCLWWVSEEELDKDK----------TYDAFISYSHKD-- 654
                 :||:..|.....|.:|      .:|::....|.|.|          .||||:.|...|
Zfish   843 FQTTLILTILTLTISSHLFLW------DVWYIYHFCLAKLKGYRRLSSNSAVYDAFVIYDTTDPA 901

  Fly   655 --EELISKLLPKLESGPHP-FRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWAR 716
              |.::.:|...||....| ..|||.:|||:.|..:.|.:.:::..|:|.:.:|::.:|.|...|
Zfish   902 VQEWVMQELRVHLEDKGDPRMNLCLEERDWVPGCPLIENLSQSIQLSQRTVFILTERYIRSGSFR 966

  Fly   717 MEFRIAYQATLQDKRKRIIIILYRELEHM 745
            ..|.:|:| .|.|:|..:|::::  ||.|
Zfish   967 TAFYLAHQ-RLMDERNDVIVLIF--LERM 992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	6/35 (17%)
		leucine-rich repeat	209..232	CDD:275380	8/30 (27%)
		leucine-rich repeat	233..261	CDD:275380	6/31 (19%)
		LRR_RI	<261..370	CDD:238064	41/181 (23%)
		leucine-rich repeat	262..284	CDD:275380	6/30 (20%)
		leucine-rich repeat	285..309	CDD:275380	10/63 (16%)
		LRR_8	309..368	CDD:290566	24/82 (29%)
		leucine-rich repeat	310..333	CDD:275380	11/45 (24%)
		leucine-rich repeat	334..357	CDD:275380	8/23 (35%)
		leucine-rich repeat	358..381	CDD:275380	9/22 (41%)
		leucine-rich repeat	445..482	CDD:275380	14/65 (22%)
		LRR_8	459..516	CDD:290566	19/59 (32%)
		leucine-rich repeat	483..505	CDD:275380	8/23 (35%)
		LRR_4	486..521	CDD:289563	14/36 (39%)
		TIR	643..779	CDD:214587	35/108 (32%)
tlr7	XP_021334735.1	LRR_8	67..131	CDD:316378
		leucine-rich repeat	83..120	CDD:275380
		PLN00113	107..>574	CDD:331614	79/361 (22%)
		leucine-rich repeat	121..165	CDD:275380
		leucine-rich repeat	142..157	CDD:275380
		leucine-rich repeat	166..197	CDD:275380
		leucine-rich repeat	199..218	CDD:275380
		leucine-rich repeat	219..242	CDD:275380	5/18 (28%)
		leucine-rich repeat	243..283	CDD:275380	6/39 (15%)
		leucine-rich repeat	284..307	CDD:275380	4/22 (18%)
		leucine-rich repeat	308..333	CDD:275380	5/28 (18%)
		leucine-rich repeat	334..363	CDD:275380	8/28 (29%)
		leucine-rich repeat	364..390	CDD:275380	5/31 (16%)
		leucine-rich repeat	391..414	CDD:275380	5/22 (23%)
		leucine-rich repeat	415..434	CDD:275380	3/18 (17%)
		leucine-rich repeat	495..516	CDD:275380	11/21 (52%)
		leucine-rich repeat	517..541	CDD:275380	8/23 (35%)
		leucine-rich repeat	542..565	CDD:275380	9/22 (41%)
		leucine-rich repeat	566..595	CDD:275380	5/28 (18%)
		leucine-rich repeat	596..616	CDD:275380	3/19 (16%)
		leucine-rich repeat	619..649	CDD:275380	3/29 (10%)
		LRR_8	<644..685	CDD:316378	6/40 (15%)
		leucine-rich repeat	650..673	CDD:275380	4/22 (18%)
		leucine-rich repeat	675..722	CDD:275380	9/50 (18%)
		LRR_8	722..781	CDD:316378	21/67 (31%)
		leucine-rich repeat	723..746	CDD:275380	8/23 (35%)
		leucine-rich repeat	747..765	CDD:275380	8/25 (32%)
		PCC	751..>828	CDD:188093	22/90 (24%)
		TIR	889..>993	CDD:214587	35/107 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010