DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and tlr8

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_002933859.2	Gene:	tlr8 / 100496108	XenbaseID:	XB-GENE-485083	Length:	1037	Species:	Xenopus tropicalis

Alignment Length:	812	Identity:	191/812 - (23%)
Similarity:	332/812 - (40%)	Gaps:	182/812 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 PRFNISSLVKIEFDAYIFWPEKFLSDL-LKTLGVQTVKTIIFRDRTLETVVTRDVLNSGNGYMET 145
            |..|:...:.|..|...|...|.|::| |.:..::|:..|.|::.|     ...:||....|:
Frog   266 PCKNLCKQISITIDPLAFQNLKNLTELHLGSTSLRTIPPIWFQNTT-----QLKILNLQLNYL-- 323

  Fly   146 SQPENITTWHFGSVPGLKKFKFFSHVPELQE-SIFHGFDTLRDLHLSVNVTTLPGNMLSTVNGTL 209
                         |..:....|..::|.|:. .:...:| ||....::|::.....::|     |
Frog   324 -------------VNEIASADFLLNLPFLEVLDLSFNYD-LRSYANNINISNHFSKLIS-----L 369

  Fly   210 KTLTIESPGIVSFGNPLLRELQQLRNL-SLALIHPFHERDKQLQPHFFGSMTNLEEVRLA----S 269
            :.|.|:  |.| |.:...:.|..|.|| .||.|:......||:....|.:::.|:.:.|:    :
Frog   370 QELHIQ--GYV-FKHIAAKNLSPLINLPKLATINLGINFIKQVDFEVFQNISGLKLIYLSENRIT 431

  Fly   270 ATSSVNRSMFKGTNKLQLIKMNGNDDLMELPGEIFLDQVNL------------------KTLDLS 316
            ..|..|:.:| |..|.|..:::.       ||..|..|.|.                  ||||||
Frog   432 PFSETNKQLF-GVCKDQSYRISS-------PGVTFPTQSNFQMTKIFSHLVKPQCSSRGKTLDLS 488

  Fly   317 CNAIVTLHEDVFKGLGNLTLLDLSKNRL-TNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVV 380
            .|:|..:..:.|:...:::.|:||.|.: .:|:.|.|..|.:|..|.|:.|.|...|.:.||::.
Frog   489 LNSIFFIDPEEFRSFSDVSCLNLSFNSIGQDLNGTEFIYLKNLTYLDLSFNKLDFDSINAFQELP 553

  Fly   381 SLNYIEM-VNTQFY---GAT--------------LLMNYEAVVCTND---EACQYKSAEWQCDPR 424
            ||..::: .|:.::   |.|              |.:::..:....|   .:...|..::..:..
Frog   554 SLEVLDLSYNSHYFIVDGVTHRLKFIENLQYLKVLNLSWNKISTLTDFRLTSHSLKELQFSGNRL 618

  Fly   425 CICW------VQRSVGSLI-VDCRGTSLE--------ELPDLPRTTLLSTVLKVGNNSLTSLPTV 474
            .:.|      .|....:|. :.|...|..        ||.:||   |..|.|.:.||.|
Frog   619 DVLWKNEDKRYQELFKNLYNLTCLDISYNRLNKMTEVELSNLP---LSLTELYLNNNKL------ 674

  Fly   475 SEHSG------YANVSGLFLSDNNLT------------------SLGSGDQLP-------DNLTH 508
             ::.|      |.|:..|.||.|.||                  |..|...||       .||:.
Frog   675 -DYFGWKALKAYKNLKHLDLSHNKLTMIMGNLSIHTYSLSSLIISYNSISSLPVAFLHKSRNLSE 738

  Fly   509 LDVRGNQIQSLSDEFLLFLQEPNNTMT-LSLSGNPITCGCESLSLLFFVRTNPQRVRDIA-DIVC 571
            ||:..|.::|::..  :||....|.:| |.|.|||..|.||....:.::..|...:..:| |:.|
Frog   739 LDLSFNHLKSINSS--VFLSGSENYLTVLGLKGNPFVCTCEITDFISWIYANNVTIPRLATDVNC 801

  Fly   572 T--KQKKSFQQMEAFELCPSYVLLI---SCVVGGLVIVICLLTVFYLMFQQELKI---------W 622
            .  :.||.           |.::..   :|.:.|..:::...:||.:|....|.|         |
Frog   802 AAPENKKG-----------SGIIFFDVHTCDLDGAAMILYFFSVFLVMSITVLPILINVFSWDLW 855

  Fly   623 LYNNNLCLWWVSEEELDKDK-TYDAFISYSHKD----EELISKLLPKLE-SGPHPFRLCLHDRDW 681
             |..:||:..:...::.|.| .||.||:|.:||    :.:.::|...|| .|.....|||.:|||
Frog   856 -YVYHLCVAKLRWHKVCKSKCLYDVFITYDNKDPNVSDWIFNELCQHLEDKGDKHMYLCLEERDW 919

  Fly   682 LVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRELEHMN 746
            ..|..|.:.:..:::.|.:.:.||::.::.|...:..|.:|.| .|.|:...:|:|:..|....|
Frog   920 EPGKAIIDNLAHSINQSNKTLFVLTKKYVKSGKFKTAFYLALQ-KLMDENMDVIVIVLLEPVLQN 983

  Fly   747 GIDSELRAYLKLNTYLKW-GDP----LFWSKL 773
            .....||..:..::.::| .:|    .||.::
Frog   984 SQYLRLRRKICKSSIMEWPKNPNTKSFFWQRM 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	4/21 (19%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..261	CDD:275380	9/28 (32%)
		LRR_RI	<261..370	CDD:238064	35/131 (27%)
		leucine-rich repeat	262..284	CDD:275380	6/25 (24%)
		leucine-rich repeat	285..309	CDD:275380	5/23 (22%)
		LRR_8	309..368	CDD:290566	22/77 (29%)
		leucine-rich repeat	310..333	CDD:275380	9/40 (23%)
		leucine-rich repeat	334..357	CDD:275380	8/23 (35%)
		leucine-rich repeat	358..381	CDD:275380	8/22 (36%)
		leucine-rich repeat	445..482	CDD:275380	12/50 (24%)
		LRR_8	459..516	CDD:290566	23/87 (26%)
		leucine-rich repeat	483..505	CDD:275380	10/46 (22%)
		LRR_4	486..521	CDD:289563	16/59 (27%)
		TIR	643..779	CDD:214587	38/141 (27%)
tlr8	XP_002933859.2	leucine-rich repeat	45..64	CDD:275380
		leucine-rich repeat	66..87	CDD:275380
		leucine-rich repeat	88..125	CDD:275380
		leucine-rich repeat	126..145	CDD:275380
		PLN00113	132..>563	CDD:215061	81/333 (24%)
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..202	CDD:275380
		leucine-rich repeat	203..223	CDD:275380
		leucine-rich repeat	224..247	CDD:275380
		leucine-rich repeat	248..288	CDD:275380	5/21 (24%)
		leucine-rich repeat	289..312	CDD:275380	7/27 (26%)
		leucine-rich repeat	313..338	CDD:275380	5/39 (13%)
		leucine-rich repeat	339..368	CDD:275380	5/29 (17%)
		leucine-rich repeat	400..419	CDD:275380	3/18 (17%)
		leucine-rich repeat	483..505	CDD:275380	9/21 (43%)
		leucine-rich repeat	509..530	CDD:275380	8/20 (40%)
		leucine-rich repeat	531..554	CDD:275380	8/22 (36%)
		leucine-rich repeat	555..584	CDD:275380	4/28 (14%)
		leucine-rich repeat	585..607	CDD:275380	2/21 (10%)
		PPP1R42	588..772	CDD:411060	45/195 (23%)
		leucine-rich repeat	608..638	CDD:275380	4/29 (14%)
		leucine-rich repeat	639..663	CDD:275380	6/26 (23%)
		leucine-rich repeat	664..687	CDD:275380	7/29 (24%)
		leucine-rich repeat	688..711	CDD:275380	6/22 (27%)
		leucine-rich repeat	712..735	CDD:275380	4/22 (18%)
		leucine-rich repeat	736..754	CDD:275380	5/19 (26%)
		TPKR_C2	770..>809	CDD:417692	10/38 (26%)
		TIR_2	877..1014	CDD:419986	38/137 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11809
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920