DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and XB5889249

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_017950848.2	Gene:	XB5889249 / 100495326	XenbaseID:	XB-GENE-5889250	Length:	796	Species:	Xenopus tropicalis

Alignment Length:	763	Identity:	169/763 - (22%)
Similarity:	298/763 - (39%)	Gaps:	179/763 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 TELQWLPRFNISSLVKIEFDAYIFWPEKFLSDLLKTLGVQTVKTIIFRDRTLETVVTRDV----- 135
            |.|..|....:|| .||:.|::|......|..:.  ||::  ..|.:.:.:|:.:.|..:
Frog   139 TALSQLKHLGLSS-KKIQKDSFINIASMDLDFVF--LGIE--NEIEYENGSLQFLNTNKLHINLQ 198

  Fly   136 --LNSGNGYMETSQPENITTWHFGSVPGLKKFKFFSHVPELQESIFHGFDTLRDLHLSVNVTTLP 198
              |:..:.|:.:...:...|......      :...|.....:|.|......:.::|.::.:|:|
Frog   199 PNLSLASSYLLSDALDTSMTLEVSGA------QCDVHCDYFTKSFFTINKNSKVVNLIISNSTMP 257

  Fly   199 GNMLSTVNGTLKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHPFHERDKQLQPHFFGSMTNLE 263
            ||.:..:...:...::|...|..|     |.:::.:.:.:...|           |...|.|
Frog   258 GNEMLKIIPPIWDSSVEHLHIKMF-----RLIKEFKYVKMDFTH-----------HSIKSFT--- 303

  Fly   264 EVRLASATSSVNRSMFKGTNKLQLIKMNGNDDLMELPGEIFLDQV---NLKTLDLSCNAIVTLHE 325
               |...|:.|  ..|:||:...:.            .|:.::.|   |...:...|..:.::
Frog   304 ---LEYFTNDV--FFFQGTHPFNIF------------AEMLVENVTFSNAGMIHFFCPPVPSI-- 349

  Fly   326 DVFKGLGNLTLLDLSKNRLTNLSSTIFAPLTSLN---VLRLNKNSLTAMSPSVFQDVVSLNYIEM 387
                    :..|:|..||:|:   .||...:|||   :|.|..|.|..||.      :|...::|
Frog   350 --------VRFLNLPSNRITD---EIFLNCSSLNELELLNLQNNKLEQMSK------ISSMTLKM 397

  Fly   388 VNTQFYGATLLMNYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSL---IVDCRGTSLEELP 449
            .|.:.    |.::...:...|::.|.:..:        :.::..|...|   :..|...:|:
Frog   398 KNLKH----LDLSKNGLHIDNEKQCNWMDS--------LVFLNLSESGLTNSVFGCLPINLQ--- 447

  Fly   450 DLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGN 514
                      :|.:..|.::|:|.  |...:.::..|.|:.|.||.:.....:.:||..|.|..|
Frog   448 ----------ILDLSKNQISSIPI--EVKNFVSLKELHLASNRLTDIPDCHNIGNNLGVLKVDEN 500

  Fly   515 QIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCE-----SLSLLFFVR----------TNPQRVR 564
            .|.....|   |||.......||...||..|.|:     .:.::|..|          .:|:.|:
Frog   501 FINLPPKE---FLQNCEYVQYLSAGQNPFQCNCDLREFVKMGVMFPKRLVGWPESYKCADPENVK 562

  Fly   565 DIADIVCTKQKKSFQQMEAFELCPSYVLLISC-------VVGGLVIVICLLTV---FYLMFQQEL 619
            .|.             ::.|.|..     |||       ||.|.:.|:.::.|   ||....
Frog   563 GIF-------------LQDFHLSE-----ISCNTSLFLGVVLGTIFVVSIIVVSACFYFDVP--- 606

  Fly   620 KIWLYNNNLCLWW--------VSEEELDKDKTYDAFISYSHKDEELI-SKLLPKLESGPHPFRLC 675
              | |...|..|:        |:::::..||.:.||||||.:|.:.: :.|||.||......::|
Frog   607 --W-YIRMLFRWFRTKHRLRNVNQQDIQNDKLFHAFISYSQEDSDWVKNMLLPNLERKDGSIKIC 668

  Fly   676 LHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYR 740
            .|:|.::.|..|.|.|:..::.|.:.|.|||.:||.|.|...|...| |.||..|....:|::..
Frog   669 HHERHFIPGKAIIENIIDCIEKSFKSIFVLSPNFIQSDWCHYELYFA-QHTLFGKNSNNLILILL 732

  Fly   741 ELEHMNGID---SELRAYLKLNTYLKW-----GDPLFWSKLYYAMPHN 780
            :......|.   ::||:.:|..|||:|     ...|||:.|..|:..|
Frog   733 DPIPQYSIPNKYNKLRSIMKHRTYLEWPKEKGKHALFWANLREAIHVN 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	5/21 (24%)
		leucine-rich repeat	209..232	CDD:275380	4/22 (18%)
		leucine-rich repeat	233..261	CDD:275380	3/27 (11%)
		LRR_RI	<261..370	CDD:238064	24/114 (21%)
		leucine-rich repeat	262..284	CDD:275380	6/21 (29%)
		leucine-rich repeat	285..309	CDD:275380	2/26 (8%)
		LRR_8	309..368	CDD:290566	15/61 (25%)
		leucine-rich repeat	310..333	CDD:275380	1/22 (5%)
		leucine-rich repeat	334..357	CDD:275380	7/22 (32%)
		leucine-rich repeat	358..381	CDD:275380	8/25 (32%)
		leucine-rich repeat	445..482	CDD:275380	6/36 (17%)
		LRR_8	459..516	CDD:290566	15/56 (27%)
		leucine-rich repeat	483..505	CDD:275380	5/21 (24%)
		LRR_4	486..521	CDD:289563	11/34 (32%)
		TIR	643..779	CDD:214587	48/144 (33%)
XB5889249	XP_017950848.2	leucine-rich repeat	48..70	CDD:275378
		PLN00113	50..>484	CDD:215061	80/437 (18%)
		LRR_8	70..129	CDD:404697
		leucine-rich repeat	71..94	CDD:275378
		leucine-rich repeat	95..118	CDD:275378
		leucine-rich repeat	119..143	CDD:275378	2/3 (67%)
		LRR	<398..>524	CDD:227223	30/155 (19%)
		leucine-rich repeat	400..423	CDD:275380	3/26 (12%)
		leucine-rich repeat	424..445	CDD:275378	3/20 (15%)
		leucine-rich repeat	446..468	CDD:275378	6/36 (17%)
		leucine-rich repeat	469..491	CDD:275378	5/21 (24%)
		leucine-rich repeat	492..515	CDD:275378	9/25 (36%)
		leucine-rich repeat	516..528	CDD:275378	4/11 (36%)
		LRRCT	524..576	CDD:214507	12/69 (17%)
		TIR	636..777	CDD:214587	47/141 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070