DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and tlr1

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_017950843.2	Gene:	tlr1 / 100495171	XenbaseID:	XB-GENE-5997911	Length:	812	Species:	Xenopus tropicalis

Alignment Length:	835	Identity:	184/835 - (22%)
Similarity:	310/835 - (37%)	Gaps:	228/835 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 ASTELQWLPRFNISSLVKIEFDAYIFWPEKFLSDLLKTLGVQTVKTIIFR-DRTLETVVTRDVLN 137
            |.|:|. |.:.||:.|...:|..::  ..|||:  |....::.:...:|: :.:||      .|:
Frog    63 ADTQLD-LTKRNITQLQTSDFSCFL--DLKFLN--LSYNSIEELDCSVFQFNPSLE------YLD 116

  Fly   138 SGNGYMETSQPE----------------NITTWHFG--------------SVPGLKKFKFFSHVP 172
            ..|..:.|.|.:                |....||.              |...::...|.:..|
Frog   117 ISNNRLHTIQCQSLQYIKNIKHLDLSYNNFKQMHFCKEFTALSQLKHLGLSAEQIQTNSFLNIAP 181

  Fly   173 ELQESIFHGFDTLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPLLRELQQLRNLS 237
            ...|.:|.|.:.|.:..                ||:|:.|..         |.||..|.  .||:
Frog   182 MQLEYVFLGMEDLTEYE----------------NGSLQFLNT---------NKLLINLP--TNLN 219

  Fly   238 LALIHPFHERDKQLQPHFFGSMTNLEEVRLASATSSVNRSMF--------KGTNKLQLIKMNGND 294
            ||        ...|......:.|.||   ::.|...|:...|        |.:..:.||..||
Frog   220 LA--------SSYLLSDALNTSTTLE---VSGAQCDVHCDYFTKSFSTITKNSKVVNLIISNG-- 271

  Fly   295 DLMELPG-EIF----------LDQVNLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLS 348
               .:|| |||          ::.:.:|...|.........:.:...:.:||:.||: |.:.:..
Frog   272 ---AMPGNEIFKIMPPIWDSSIEHLYIKIFRLQNELKYVKMDFLHHSIKSLTVEDLT-NEVVSFR 332

  Fly   349 ST----IFA--------------------PLTSL-NVLRLNKNSLTAMSPSVFQDVVSLNYIEMV 388
            .|    :||                    |..|: .|:.|..|.||   ..:||:..:|..:|::
Frog   333 DTHPLQMFAEMLVENITFSRAELYFFFCPPAPSIFRVINLPSNRLT---DDIFQNCANLKELELL 394

  Fly   389 NTQ---------FYGATLLM--------NYEAVVCTNDEACQYKSAEWQCDPRCICWVQRSVGSL 436
            |.|         ....||.|        :...:...|::.|::..:        :.::..|...|
Frog   395 NLQNNKLEQMSKISSMTLTMPNLKHLDLSRNGLHIDNEKQCKWMDS--------LVFLNLSESGL 451

  Fly   437 ---IVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLFLSDNNLTSLGS 498
               :..|...:|:             :|.:..|.::|:|.  |...:.::..|.|:.|.||.:..
Frog   452 TNSVFGCLPINLQ-------------ILDLSKNQISSIPI--EVKNFVSLKELHLASNRLTDIPD 501

  Fly   499 GDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCE-----SLSLLFFVR- 557
            ...:.:||..|.|..|.|...|.|   |||.......||...||..|.|:     .:.::|..|
Frog   502 CHNIGNNLGVLKVDENLINLPSKE---FLQNCEYVKYLSAGKNPFQCNCDLREFVKMGVMFPKRL 563

  Fly   558 ---------TNPQRVRDIADIVCTKQKKSFQQMEAFELCPSYVLLISCVVGGLVI--VICLLTVF 611
                     .:|:.:|.|          ..|.....|:..:..:|:..|:|.:.|  :|.:...|
Frog   564 IGWPESYKCADPENLRGI----------FLQDFYLPEISCNISMLLGVVLGTIFILSIIVVSACF 618

  Fly   612 YLMFQQELKIWLYNNNLCLWW--------VSEEELDKDKTYDAFISYSHKDEELI-SKLLPKLES 667
            |....     | |...|..|:        |:::::..||.:.||||||.:|.:.: :.|||.||.
Frog   619 YFDVP-----W-YIRMLFRWFRTKHRLRNVNQQDIQNDKLFHAFISYSQEDSDWVKNMLLPNLER 677

  Fly   668 GPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQATLQDKRK 732
            .....::|.|:|.::.|..|.|.|:..::.|.:.|.|||.:||.|.|...|...|..........
Frog   678 KDGSIKICHHERHFIPGKAIIENIIDCIEKSFKSIFVLSPNFIQSDWCHYELYFAQHTLFGKNSN 742

  Fly   733 RIIIILYRELEH--MNGIDSELRAYLKLNTYLKW-----GDPLFWSKLYYAMPHN 780
            .:|:||...:..  :....::||:.:|..|||:|     ...|||:.|..|:..|
Frog   743 NLILILLDPIPQYLIPNKYNKLRSIMKHRTYLEWPKEKGKHALFWANLREAIHVN 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	1/21 (5%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		leucine-rich repeat	233..261	CDD:275380	5/27 (19%)
		LRR_RI	<261..370	CDD:238064	31/152 (20%)
		leucine-rich repeat	262..284	CDD:275380	6/29 (21%)
		leucine-rich repeat	285..309	CDD:275380	9/34 (26%)
		LRR_8	309..368	CDD:290566	15/83 (18%)
		leucine-rich repeat	310..333	CDD:275380	2/22 (9%)
		leucine-rich repeat	334..357	CDD:275380	9/46 (20%)
		leucine-rich repeat	358..381	CDD:275380	7/23 (30%)
		leucine-rich repeat	445..482	CDD:275380	6/36 (17%)
		LRR_8	459..516	CDD:290566	15/56 (27%)
		leucine-rich repeat	483..505	CDD:275380	5/21 (24%)
		LRR_4	486..521	CDD:289563	11/34 (32%)
		TIR	643..779	CDD:214587	45/143 (31%)
tlr1	XP_017950843.2	leucine-rich repeat	65..87	CDD:275378	7/24 (29%)
		PLN00113	88..>501	CDD:215061	92/490 (19%)
		leucine-rich repeat	88..111	CDD:275378	5/24 (21%)
		leucine-rich repeat	112..135	CDD:275378	6/28 (21%)
		leucine-rich repeat	136..160	CDD:275378	3/23 (13%)
		leucine-rich repeat	161..173	CDD:275378	1/11 (9%)
		leucine-rich repeat	184..205	CDD:275380	7/36 (19%)
		leucine-rich repeat	417..440	CDD:275380	2/22 (9%)
		leucine-rich repeat	441..462	CDD:275380	3/20 (15%)
		leucine-rich repeat	463..485	CDD:275380	6/36 (17%)
		leucine-rich repeat	486..508	CDD:275380	5/21 (24%)
		leucine-rich repeat	509..532	CDD:275380	10/25 (40%)
		TPKR_C2	541..>580	CDD:417692	7/38 (18%)
		TIR	653..794	CDD:214587	44/140 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070