DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and tlr6

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_017950845.1	Gene:	tlr6 / 100493946	XenbaseID:	XB-GENE-492949	Length:	842	Species:	Xenopus tropicalis

Alignment Length:	846	Identity:	194/846 - (22%)
Similarity:	312/846 - (36%)	Gaps:	257/846 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 FDAYIF-WPEKFLSDLLKTL-GVQTVKTIIFRD-RTLET-----VVTRDVLNSGNGYMETSQPEN 150
            |:::|. :..|||..:.|.| .:.||..|.|.. .|:||     :....|||:
Frog    23 FESHIANYSNKFLFAVPKNLSSLTTVLDISFNSIATMETSEFNYIFDLQVLNA------------ 75

  Fly   151 ITTWHFGSVPGLKKFKFFSHVPELQESIFHGFDTLRDLHLSVNVT-----TLPGNM--LSTVNGT 208
                      ...|.|:      |..|||.....|:.|..|.||.     |.|.::  |......
Frog    76 ----------SYNKMKY------LNSSIFKFNTQLQYLDFSHNVLRNISGTFPSHIQHLDISFNN 124

  Fly   209 LKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHPFHERDKQLQPHFFGSM-TNLEEV--RLASA 270
            .:||::.|    .|||.:|     |..|.|.       .|:.|:..|.|.: .:|:||  .|.|.
Frog   125 FQTLSVCS----GFGNMVL-----LEYLGLG-------ADQILKSDFEGIVHLHLKEVFIELNSL 173

  Fly   271 TSSVNRS-MFKGTNKLQL-IKMNGNDD-------------LMEL-----------PGEIFLDQV- 308
            ....|.| :...|.||.| ..:..|:|             ::||           |.:...:.|
Frog   174 NDYENGSLLLLNTKKLTLDFGVLSNEDRYNVLFDAVNTTSVLELSHLQRWNIHIDPKKYIFNIVQ 238

  Fly   309 NLKTLDLSCNAI---------------------VTLHEDVFKGLGNLTLLDLSKNRLTNLS---- 348
            |.|..||:...:                     :|.::...|||...|..|.|...:..::
Frog   239 NSKVTDLTMRHVNVEWKMIVLALQYIWHSSVETLTFYDFSLKGLIAKTSFDYSNTSVKAVNVQGV 303

  Fly   349 ---------STIFAPLTSLNV--LRLNKNSLTAM----SPSVFQDVVSLNYIEMVNTQFYGATLL 398
                     |:::...:::|:  |.||..||..|    :.|.||. :..::..:.:..|.....|
Frog   304 NVGVFQFDQSSVYRVFSNMNIENLTLNFASLLFMVCPLNSSTFQS-IDFSHNALTDDLFKDCFTL 367

  Fly   399 MNYE---------------AVVCTNDEACQYKSA--------EWQCDPRCICWVQRSV------- 433
            :|.:               :.:..|..:.:|..|        |..|.     |.|..|
Frog   368 INLKRLKLRKNKLEKIYKLSAMTENMPSLEYLDASHNLLAYDEEDCH-----WSQNIVELNLASN 427

  Fly   434 --GSLIVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLTSLPTVSEHSGYANVSGLF---LSDNNL 493
              .:.|..|...|::             :|.:.:|.:|.:|     ||..::..|.   ||.|.|
Frog   428 FLTASIFKCLPISIK-------------ILILESNDITHVP-----SGVTHLDDLVELNLSFNRL 474

  Fly   494 TSLGSGDQLPD-----NLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGNPITCGCESLSLL 553
                 || |||     :|:.|.|.||||...|.|   .::..:....:|...||..|.||....:
Frog   475 -----GD-LPDCSNISSLSLLGVEGNQILYPSIE---SIESCSRVKHISAGQNPFQCNCELRRFI 530

  Fly   554 ---------------FFVRTNPQRVRD-------IADIVCTKQKKSFQQMEAFELCPSYVLLISC 596
                           .:|...|..:|.       |::|.|          ..|.|.|  |:::..
Frog   531 NQEKEAPGTLIGWPEAYVCKYPDHLRGTMLKDFYISEITC----------NVFILIP--VIILPI 583

  Fly   597 VVG-GLVIVICLLTVFYLMFQQELK-IWLYNNNLCLWWVSE---EELDKDKTYDAFISYSHKDEE 656
            ::. .|:|.:|.    ||.....|| ||.|.........|:   :.|.:|..::||||||..|..
Frog   584 IISIALIIGLCK----YLDGPWFLKMIWQYTRTKQRTRTSKQGYQSLQRDFDFNAFISYSEHDAS 644

  Fly   657 LISKL-LPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFR 720
            .:..: ||.:|......|:|.|:|:::.|..|.|.|:..::.|.:.|.:||.:|:.|.|...|..
Frog   645 WVKNIFLPSIERSNDCIRICQHERNFIPGKSIIENIINCIEKSYKSIFILSPNFVQSEWCHYELY 709

  Fly   721 IAYQATLQDKRKRIIIILYREL-EHMNGIDS---ELRAYLKLNTYLKWGDP-----LFWSKLYYA 776
            .|:.....:....:|:||...: :::  |.|   :|:..:...|||:|...     |||:.|..|
Frog   710 FAHHKLYTENNDNLILILLEPIPQYL--IPSKYYKLKTLMAQRTYLEWPSEKSKHGLFWANLRAA 772

  Fly   777 M 777
            :
Frog   773 I 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	8/28 (29%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		leucine-rich repeat	233..261	CDD:275380	7/28 (25%)
		LRR_RI	<261..370	CDD:238064	35/173 (20%)
		leucine-rich repeat	262..284	CDD:275380	8/24 (33%)
		leucine-rich repeat	285..309	CDD:275380	8/49 (16%)
		LRR_8	309..368	CDD:290566	16/94 (17%)
		leucine-rich repeat	310..333	CDD:275380	7/43 (16%)
		leucine-rich repeat	334..357	CDD:275380	4/35 (11%)
		leucine-rich repeat	358..381	CDD:275380	10/28 (36%)
		leucine-rich repeat	445..482	CDD:275380	6/36 (17%)
		LRR_8	459..516	CDD:290566	21/64 (33%)
		leucine-rich repeat	483..505	CDD:275380	10/29 (34%)
		LRR_4	486..521	CDD:289563	17/42 (40%)
		TIR	643..779	CDD:214587	42/145 (29%)
tlr6	XP_017950845.1	leucine-rich repeat	46..69	CDD:275378	7/22 (32%)
		LRR_8	70..125	CDD:404697	17/82 (21%)
		leucine-rich repeat	70..93	CDD:275378	9/50 (18%)
		leucine-rich repeat	94..114	CDD:275378	7/19 (37%)
		leucine-rich repeat	115..139	CDD:275378	7/27 (26%)
		LRR_RI	311..>478	CDD:423007	38/196 (19%)
		leucine-rich repeat	347..369	CDD:275380	3/22 (14%)
		leucine-rich repeat	370..395	CDD:275380	1/24 (4%)
		leucine-rich repeat	396..418	CDD:275380	5/26 (19%)
		leucine-rich repeat	419..440	CDD:275380	3/20 (15%)
		leucine-rich repeat	441..463	CDD:275380	6/39 (15%)
		leucine-rich repeat	464..485	CDD:275380	10/26 (38%)
		leucine-rich repeat	486..509	CDD:275380	9/25 (36%)
		LRRCT	518..570	CDD:214507	10/51 (20%)
		TIR	632..775	CDD:214587	42/144 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24365
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.070