DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and tlrs5

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_002937550.2	Gene:	tlrs5 / 100489423	XenbaseID:	XB-GENE-22201327	Length:	653	Species:	Xenopus tropicalis

Alignment Length:	548	Identity:	125/548 - (22%)
Similarity:	196/548 - (35%)	Gaps:	177/548 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QIIPLPTFCLGLSPQCTCAAEGNVVRFHCPDEYAMLLEVSEPGASLYMSYYASTELQW--LPR-- 83
            ::.|.||| |.||.......:.|.|...|.::...|     .|..|.:...:|..||.  .|.
Frog   170 RVRPDPTF-LKLSSISFLLLKFNKVSMLCGEDLQNL-----QGRRLQLLDMSSNPLQLSSTPHCT 228

  Fly    84 --FNISSLVKIEFDAYIFWPEKFLSDLLKTLGVQTVKTIIFRDRTLETVVTRDVLNSGNGYMETS 146
              ||..:|..::..: :.|..:.:.:.::|:....|..|..|...        .|.||.|:....
Frog   229 NPFNNITLGTLDVSS-MGWNAEMVENFVRTISGTQVDYIKMRHTA--------GLGSGFGFHNLK 284

  Fly   147 QPENITTWHFGSVPGLKKFK---------FFSH-VPELQESIFHGFDTLRDLHLSVN-------- 193
            .|...|      ..||....         |.|| ||:|    |..|..|..|.||.|
Frog   285 DPNKDT------FSGLNSSNVQILDLSNGFISHLVPQL----FSAFPKLLSLDLSSNQINRMSSG 339

  Fly   194 ---------VTTLPGNMLSTVNG---------TLKTLTIESP--GIVSFGNPLLRELQQLRNLSL 238
                     ...|.||:|..:.|         :||||.:.|.  |.|.:|  .|.....|.:|:|
Frog   340 AFSGLGELVSLNLSGNLLGELMGSSFQGLGATSLKTLDLSSNHIGAVQYG--ALDSFTALTSLNL 402

  Fly   239 ALIHPFHERDKQLQ------------------------------PHF------------FGSMTN 261
                    ||..|.                              ||.            |.|:..
Frog   403 --------RDNALNKIPPTKLQGVTFVLLKQNRISDIYNIISFCPHATILDLSSNRLTDFRSLWQ 459

  Fly   262 LEEVR----LASATSSVNRSMFKGTNKLQ----LIKMNGNDDLMELP-------GEIFLDQVNLK 311
            :.|::    |:.|::|:.|.....|:.:.    |:.::.:|:.:. |       |:||:...:||
Frog   460 ILELQSLKYLSLASNSLYRCSLPHTSNITRTSGLVYLDLSDNALG-PVLKSGECGDIFMHLGSLK 523

  Fly   312 TLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVF 376
            :|:|:.|.:..:.:.:|:.|.:|..||||.|....:.|.:|..||:|..|.|.|::|..:|.||.
Frog   524 SLNLARNQLSNIPDTMFRSLSSLQTLDLSGNGFKEIQSNLFTGLTALKTLNLGKSNLVTLSSSVL 588

  Fly   377 QDVVSLNYIEMVNTQFYGATLLMNYEAVVCTNDEACQYKSAEWQCDPRCICW----------VQR 431
            ..:.||..|::..     .||:                      ||  |..|          |..
Frog   589 DPLGSLESIDLSE-----VTLV----------------------CD--CSLWDFWKWLEDTNVTV 624

  Fly   432 SVGSLIVDCRGTSLEELPDLPRTTLLST 459
            :||...|.|...: ..:|::|..|.|.:
Frog   625 NVGKQEVLCIQPT-PRIPEIPLATFLKS 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	9/38 (24%)
		leucine-rich repeat	209..232	CDD:275380	9/24 (38%)
		leucine-rich repeat	233..261	CDD:275380	10/69 (14%)
		LRR_RI	<261..370	CDD:238064	34/123 (28%)
		leucine-rich repeat	262..284	CDD:275380	6/25 (24%)
		leucine-rich repeat	285..309	CDD:275380	6/34 (18%)
		LRR_8	309..368	CDD:290566	21/58 (36%)
		leucine-rich repeat	310..333	CDD:275380	7/22 (32%)
		leucine-rich repeat	334..357	CDD:275380	9/22 (41%)
		leucine-rich repeat	358..381	CDD:275380	8/22 (36%)
		leucine-rich repeat	445..482	CDD:275380	4/15 (27%)
		LRR_8	459..516	CDD:290566	0/1 (0%)
		leucine-rich repeat	483..505	CDD:275380
		LRR_4	486..521	CDD:289563
		TIR	643..779	CDD:214587
tlrs5	XP_002937550.2	PLN00113	100..>597	CDD:215061	109/462 (24%)
		leucine-rich repeat	108..131	CDD:275380
		leucine-rich repeat	132..157	CDD:275380
		leucine-rich repeat	158..182	CDD:275380	6/12 (50%)
		leucine-rich repeat	183..208	CDD:275380	5/29 (17%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	299..322	CDD:275380	8/26 (31%)
		leucine-rich repeat	323..346	CDD:275380	5/22 (23%)
		leucine-rich repeat	347..372	CDD:275380	5/24 (21%)
		leucine-rich repeat	373..396	CDD:275380	9/24 (38%)
		leucine-rich repeat	397..440	CDD:275380	6/50 (12%)
		leucine-rich repeat	418..431	CDD:275378	0/12 (0%)
		leucine-rich repeat	441..492	CDD:275380	8/50 (16%)
		leucine-rich repeat	493..521	CDD:275380	6/28 (21%)
		leucine-rich repeat	522..545	CDD:275380	7/22 (32%)
		leucine-rich repeat	546..569	CDD:275380	9/22 (41%)
		leucine-rich repeat	570..591	CDD:275380	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920