DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tehao and tlr14.2

DIOPT Version :9

Sequence 1:	NP_001285901.1	Gene:	Tehao / 34761	FlyBaseID:	FBgn0026760	Length:	795	Species:	Drosophila melanogaster
Sequence 2:	XP_012810129.1	Gene:	tlr14.2 / 100485512	XenbaseID:	XB-GENE-5824915	Length:	844	Species:	Xenopus tropicalis

Alignment Length:	871	Identity:	194/871 - (22%)
Similarity:	332/871 - (38%)	Gaps:	264/871 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTYLPVVWLFFALLVLR-----------SATGQI----IPLPTFCLGLSPQCTCAAEGNVVRFHC 51
            ||.:|.. ||..||:|.           |..|::    :.|....:|          |.:|....
Frog   135 LTEMPST-LFEPLLLLEFLDVSNNLYNYSTLGKVFENLVNLQNLAIG----------GPLVSKVL 188

  Fly    52 PDEYAML---------------LEVSEPGASLYMSYYASTELQWLPRFNISSLVKIEFDAYIFWP 101
            .|::|.:               |...||||...:    :|.:.||.       :.::.:|
Frog   189 KDDFAPIKNRSLKKFSLKTMSKLGFYEPGALEVL----NTRVLWLD-------ISLDTNA----- 237

  Fly   102 EKFLSDLLKTLGVQTVKTIIFRDRTLETVVTRDVLNSGNGYMETSQPENITTWHFGSVPGLKKFK 166
             :.|..:||.|..:|:.::.|| |..|:....|.::...|.::.:               :::..
Frog   238 -QALPLILKDLAGKTIDSLRFR-RLFESSYYTDTMDLFCGLVDIN---------------IRELI 285

  Fly   167 FFSHVPELQESIFHGFDTLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPLLRELQ 231
            ||..:  ..|::.|     :.|| |:..:|:...:|.:|... ::|...:..|: |....|..|
Frog   286 FFRGM--FTENLLH-----QALH-SIQKSTIQDLLLLSVKFD-RSLNTNNTHIL-FDRLYLNSL- 339

  Fly   232 QLRNLSLALIHPFHERDKQLQPHFF---GSMTNLEEVRLASATSSVNRSMFKGTNKLQLIKMNGN 293
            .:|:::              .||.|   .:.|...:||                 .|||.:::
Frog   340 VIRDIA--------------GPHIFKYDWTFTWFSKVR-----------------NLQLSRVH-- 371

  Fly   294 DDLMELPGEIFLDQVNLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIFAP---- 354
              |..||                |.|        ::.:||:..||:|.|||  :.|.::.|
Frog   372 --LGSLP----------------CIA--------WRQMGNIECLDVSDNRL--IGSNLYNPSCWD 408

  Fly   355 ---------------LTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLMNYEAV 404
                           |.||.::.|    |||..|.:.:..:|.|.:.:.|.
Frog   409 GGLPKLDTFIAANNNLQSLRLISL----LTAKWPKLTKLDLSSNDLGVYNE-------------- 455

  Fly   405 VCTNDEACQYKSAEWQCDPRCICWVQRSVGSLIVDCRGTSLEELPDLPRTTLLSTVLKVGNNSLT 469
            |||           |..:...:.....::...:..|..||: ||.||..:.|....|...|.:
Frog   456 VCT-----------WIPNITTLILKGNTLKMCVFQCLPTSV-ELLDLSYSQLEQLDLNYFNRA-- 506

  Fly   470 SLPTVSEHSGYANVSGLFLSDNNLTSLGSGDQLPDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTM 534
                       .|:..|.||.|.|..:.|..:.| ||..|.:.||.| ||.|:. .|...| :..
Frog   507 -----------TNLKELVLSHNKLNFISSDWRSP-NLQVLHLEGNSI-SLIDKG-TFKDLP-SLR 556

  Fly   535 TLSLSGNPITCGCESLSLLFFVRTN----------------PQRVR--DIADIVCTKQKKSFQQM 581
            .|:...||..|.|:..:....::.|                ||.:|  |:.|....:
Frog   557 RLTAGNNPYDCTCDLYAFFSTLQNNDEMLLADWPYDYQCFHPQHLRDTDVEDYTPWR-------- 613

  Fly   582 EAFELCPSYVLLISCVVGGLVIVICLLTV------FYLMFQQELKIWLYNNNLCLWWVSEEELDK 640
              .|...|.|:.||......:|::|:|..      :||.....:....|.:       .:....:
Frog   614 --VECDVSLVITISVSTTAAIIILCMLVCWRFDVPWYLRMTWRIVKSKYRS-------KKSNKSR 669

  Fly   641 DKTYDAFISYSHKDEELI-SKLLPKLESGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIV 704
            :..|.||||||:.|.:.: .:||.:|||...|:|:|:|:||:|.|..|.:.|:..:::|:::|.|
Frog   670 EYNYHAFISYSYSDADWVRGELLYRLESCSPPYRVCIHERDFLPGRWIIDNIIENIENSRKIIFV 734

  Fly   705 LSQHFIDSVWARMEFRIAYQATLQDKRKRIIIILYRE--LEHMNGIDSELRAYLKLNTYLKW-GD 766
            ||.:||:|.|...|...|:|..:....:.||:::..:  :|.:.....:||..|:..|||:| .:
Frog   735 LSSNFINSEWCNYELYFAHQRAIGHSLEDIILVVKEKVTMEDLPKRFHKLRKMLRTKTYLEWPSE 799

  Fly   767 P----LFWSKLYYAMPHNRRVLKGQK 788
            |    .||.:|...:......|.||:
Frog   800 PSKQHFFWIQLKSILGDASVSLAGQE 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tehao	NP_001285901.1	leucine-rich repeat	185..207	CDD:275380	6/21 (29%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		leucine-rich repeat	233..261	CDD:275380	4/30 (13%)
		LRR_RI	<261..370	CDD:238064	25/127 (20%)
		leucine-rich repeat	262..284	CDD:275380	2/21 (10%)
		leucine-rich repeat	285..309	CDD:275380	6/23 (26%)
		LRR_8	309..368	CDD:290566	16/77 (21%)
		leucine-rich repeat	310..333	CDD:275380	2/22 (9%)
		leucine-rich repeat	334..357	CDD:275380	9/41 (22%)
		leucine-rich repeat	358..381	CDD:275380	6/22 (27%)
		leucine-rich repeat	445..482	CDD:275380	7/36 (19%)
		LRR_8	459..516	CDD:290566	15/56 (27%)
		leucine-rich repeat	483..505	CDD:275380	7/21 (33%)
		LRR_4	486..521	CDD:289563	15/34 (44%)
		TIR	643..779	CDD:214587	49/143 (34%)
tlr14.2	XP_012810129.1	LRR_8	76..135	CDD:338972	194/871 (22%)
		leucine-rich repeat	77..100	CDD:275378
		leucine-rich repeat	101..124	CDD:275378
		leucine-rich repeat	125..148	CDD:275378	6/13 (46%)
		leucine-rich repeat	149..173	CDD:275378	3/23 (13%)
		leucine-rich repeat	219..280	CDD:275380	15/78 (19%)
		leucine-rich repeat	281..321	CDD:275380	10/48 (21%)
		LRR	299..>558	CDD:227223	80/370 (22%)
		leucine-rich repeat	365..385	CDD:275380	8/47 (17%)
		leucine-rich repeat	386..413	CDD:275380	8/28 (29%)
		leucine-rich repeat	414..435	CDD:275380	5/24 (21%)
		leucine-rich repeat	440..484	CDD:275380	8/68 (12%)
		leucine-rich repeat	485..508	CDD:275380	7/36 (19%)
		LRR_8	508..564	CDD:338972	20/59 (34%)
		leucine-rich repeat	509..530	CDD:275380	7/21 (33%)
		leucine-rich repeat	531..554	CDD:275380	10/25 (40%)
		TPKR_C2	563..>603	CDD:387596	7/39 (18%)
		TIR	673..810	CDD:214587	48/136 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3846
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	1	1.000	-	-		FOG0000239
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.060