DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10859 and dic1

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001342791.1	Gene:	dic1 / 5802757	PomBaseID:	SPBC646.17c	Length:	544	Species:	Schizosaccharomyces pombe

Alignment Length:	510	Identity:	102/510 - (20%)
Similarity:	163/510 - (31%)	Gaps:	97/510 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PINERTQLSEQYAASSVLTHNVTLD-SHGLNHYEGGWNV--------KEVNIMDEESTMRYRKKV 103
            |.|...|.....:.||.|..:..|. |.....|...:||        |.|||.:....:::..|.
pombe    55 PTNLTPQTYSLESKSSNLVSDCELKISSVYQSYSSTFNVSNHVPSISKTVNIRETSKHLKHSTKA 119

  Fly   104 ERDDSWGIEVNQLMHAAMDISSANNAVNIYEDFFVDLPEDLGRGISMKIAARGTHVFHDLWIPSR 168
            .:        ..|..:|::|...||       |.....:.|.|.    :..:...:|.|..:..:
pombe   120 PK--------CSLPTSALEIDHLNN-------FLHSSAKILDRA----LCDQSNQLFTDYTVKKK 165

  Fly   169 RLMTCEWL-NNDPNQFLLFYSNRMSLT-----------------PDYTKQLNTLPDFGNDNPHAF 215
            .......| .|..|....|...:::|.                 ..|.|....|...|     ..
pombe   166 SKKNKSQLEENGLNHLFTFQDEKITLNSVVNSISYSSFFEELLITSYAKPKEALRTRG-----LA 225

  Fly   216 YIWNLDDATRPAAHYDSRRVVRVAKVCLRDESYMVGGLQEGQVGFW-LTENQGGPKSMCPLEACH 279
            .:||......|.:...:|..:.|.|........:.||...|||..| |.:.|........:...|
pombe   226 IVWNQRWKNSPESVLKARSEITVCKPSPFHPQLIAGGAYNGQVFLWDLRQGQYPVSFTTIISGGH 290

  Fly   280 REATTAICWVHSKLNTEFYSGSLDGSIKYWDTRDLLMPVHEVLAEPDPQTVQNRQDAHGVTFLEF 344
            .|..|.|.::::..:....:.|.||.:..|:......|...:...   ..|.:.......|.|.|
pombe   291 LEPVTDITYINNPPSNNIVTCSTDGLVHIWEPDMFSRPSETICLS---SQVDSSSQCIPATCLSF 352

  Fly   345 EYTIP---VRFIFCTDMGYLFVGNR------KGTTPQDTIVAAYQLFAGPIRCV---MRNPFFVK 397
               ||   :.|:...:.|.|..|.|      |...|.:.....:.:|...|..:   .:|.|..|
pombe   353 ---IPENNMEFLVGAEDGKLQRGYRSDYSETKAVQPSNVSYEGHNVFISGIDVMTSNSQNVFLEK 414

  Fly   398 N--FLVVG--DWRVRIW-----------------SEEV--KNCPSTFYFRRPNQLLSGAWSTGRC 439
            |  |.:..  ||.||:|                 .|:|  .:|.:   |.....:....|.....
pombe   415 NKDFALTSSFDWTVRLWQCSPSRNQHELVPSNDLDEQVIINSCKT---FTHKAMVFDVKWCVSEP 476

  Fly   440 SLFCIGDNMGNLEFWDLLMSHKRPILT-IKYKYAVTHLVFKPDGTMLTVSLANGD 493
            ..|...|.:|||..|||....:.|:.: |.....:..:.::|:...|.....||:
pombe   477 CCFASVDALGNLNLWDLQKDVEAPVTSDIPDGKPLNKIAWQPEKRNLACGGLNGN 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	15/65 (23%)
		WD40	261..>512	CDD:225201	56/270 (21%)
		WD40	279..492	CDD:295369	51/248 (21%)
		WD40 repeat	284..332	CDD:293791	8/47 (17%)
		WD40 repeat	386..422	CDD:293791	14/61 (23%)
		WD40 repeat	429..454	CDD:293791	6/24 (25%)
dic1	NP_001342791.1	WD40	223..536	CDD:330360	68/323 (21%)
		WD40 repeat	247..289	CDD:293791	10/41 (24%)
		WD40 repeat	294..339	CDD:293791	7/47 (15%)
		WD40 repeat	348..390	CDD:293791	12/44 (27%)
		WD40 repeat	397..453	CDD:293791	12/55 (22%)
		WD40 repeat	466..504	CDD:293791	10/37 (27%)
		WD40 repeat	511..535	CDD:293791	4/21 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770