DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10859 and dnai2a

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_017213955.1	Gene:	dnai2a / 563648	ZFINID:	ZDB-GENE-070410-46	Length:	567	Species:	Danio rerio

Alignment Length:	584	Identity:	169/584 - (28%)
Similarity:	280/584 - (47%)	Gaps:	73/584 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GRQCLFTDRNEMILSVQPSGRLRLKYILRNPINERTQLSEQYAASSVLTHNVTLDSHGLNHYEGG 82
            ||.|.|:::..:...:.|...|.|:||.|...:..||.|:.::...|...:....|||:||.|||
Zfish    24 GRWCKFSEKAVVHDDIPPDPSLALEYIDRGTCHVGTQFSKFWSQHEVTPFHTEQVSHGMNHVEGG 88

  Fly    83 WNVKEVNIMDEESTMRYRKKVERDDSWG---IEVNQLMHAAMDISSANNAVNIYED---FFVD-- 139
            | .:.::..::|.|:||||||::|:|:.   ||...:|.        |....::|.   :|.|
Zfish    89 W-PETISANNDELTLRYRKKVQKDESYQQTVIETVSVME--------NYKQKVFEKSQVYFKDNR 144

  Fly   140 ---LPEDLGRGISMKIAARGTHVFHDLWIPSRRLMTCEWLNNDPNQFLLFYSNRMSLTPDYTKQL 201
               ..||:.       :||..:|..|.....|...:..|...|.::..:.||         ..:.
Zfish   145 VVVKREDMA-------SARIINVLRDPKKEKRAATSLSWHPVDNHKLAVAYS---------CVEF 193

  Fly   202 NTLP-DFGNDNPHAFYIWNLDDATRPAAHYDSRRVVRVAKVCLRDESYMVGGLQEGQVGFWLTEN 265
            ...| :..:|:    ||||:::..:|.....|...:...:..|::.|.::||...||:|:|.|.:
Zfish   194 QRGPKNMSSDS----YIWNIENNKQPEMTLKSVSPLVCLEYNLKNISILIGGSYNGQIGYWDTRS 254

  Fly   266 QGGPKSMCPLEACHREATTAICWVHSKLNTEFYSGSLDGSIKYWDTRDLLMPVHEVLAEPDPQTV 330
            ...|..:..:|..|::....:.|:.:|:.||.:|.|.||.:.:||.|::..|..:::.  ||...
Zfish   255 GSQPVQISAIEHSHKDPVYKVIWLQTKIGTEAFSASTDGQVLFWDIRNMSEPTKQLIL--DPAKS 317

  Fly   331 QNRQDAHGVTFLEFEYTIPVRFIFCTDMGYLFVGNRKGTTPQDTIVAAYQLFAGPIRCVMRNPFF 395
            :|..:|.|...:||:.|:| :|:..|:.|.:.:.|||..|..:.||..|....||:..|.|||||
Zfish   318 KNLNNAFGAFSMEFDNTMP-KFLVGTEQGLVVLCNRKLETTDEPIVCTYSGHLGPVYAVQRNPFF 381

  Fly   396 VKNFLVVGDWRVRIWSEEVK--NCPSTFYFRRPNQLLSGAWSTGRCSLFCIGDNMGNLEFWDLLM 458
            .|.||.|.||..|||||:::  :..||.|  ..:.|:.|.||..|.::|......|.|:.||:|:
Zfish   382 PKYFLTVADWTARIWSEDIRLSSIMSTKY--HTSHLMDGCWSPVRPAVFFTVKMDGTLDVWDILL 444

  Fly   459 SHKRPILTIK------YKYAVTHLVFKPDGTMLTVSLANGDCLMLRLEEGMRSATNKEKSLMMSM 517
            ..|.|:|::|      |...|     |.|..::......|...:|::...:.:..:.||.|:..|
Zfish   445 KQKDPVLSLKVCDETLYSIRV-----KNDSPLMCCGSQLGTVTLLKMSPNLCTLQSNEKGLVSEM 504

  Fly   518 FEREIQRCKLLEA-------------REEEIKLKKRLTTIFLEEERKSREKLEAKKKKGQAKKE 568
            ||||.:|.|:|||             :||| ..:..|..:..|.|.:..|.:..:|||.|..::
Zfish   505 FERETKREKILEAFYKERNQMKQSCPKEEE-DGRAELQELLAETETEFFEAINVEKKKIQVDEK 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	19/64 (30%)
		WD40	261..>512	CDD:225201	80/258 (31%)
		WD40	279..492	CDD:295369	73/220 (33%)
		WD40 repeat	284..332	CDD:293791	14/47 (30%)
		WD40 repeat	386..422	CDD:293791	19/37 (51%)
		WD40 repeat	429..454	CDD:293791	8/24 (33%)
dnai2a	XP_017213955.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217312at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2212
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.020