DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10859 and dnai1.2

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001074027.1	Gene:	dnai1.2 / 555705	ZFINID:	ZDB-GENE-070112-1302	Length:	660	Species:	Danio rerio

Alignment Length:	490	Identity:	108/490 - (22%)
Similarity:	190/490 - (38%)	Gaps:	104/490 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 RYRKKVERDDSWGIEVNQLMHAAMDISSANNAVNIYED------FFVDLPE-------------- 142
            |.:||:.:.::...:::||...|..|....|. ||:::      :|.|..:
Zfish   231 RSKKKMIQAEAQSDDISQLAKPAEIIERMVNQ-NIFDEVAQDFMYFEDAADEFRGEKGTLLPLWK 294

  Fly   143 ---DLGRGISMKIAARGTHVFHDLWIPSRRLMTCEWLNNDPNQFLLFYSNRMSLTPDYTKQLNTL 204
               |..:|:|: .|....|::.||:...  |.:.|:...: ...||||:.:   .|.:
Zfish   295 FQYDKAKGLSV-TALCWNHIYSDLFAVG--LGSYEFTQQE-RGMLLFYTLK---NPSF------- 345

  Fly   205 PDFGNDNPHAFYIWNLDDATRPAAHYDSRRVVRVAKVCLRDE-SYMVG-GLQEGQVGFW-LTENQ 266
            |:|         |:|.|..              |..|.:.:: ||:|. ||.:|.|..: |.:..
Zfish   346 PEF---------IFNTDSG--------------VMCVDIHEQLSYLVAVGLYDGCVSVYDLRKKS 387

  Fly   267 GGPK-SMCPLEACHREATTAICWVHSKL--NTEFYSGSLDGSIKYWDT-------RDL--LMPVH 319
            ..|. :.......|..|...:.|....|  |..|:|.|.||.:..|..       .|:  |.||.
Zfish   388 DQPMYNSIASSGKHTGAVWQVKWQKDDLDSNHNFFSVSTDGRVVSWTLVKHEIVFTDIIKLPPVD 452

  Fly   320 EVLAEPDPQTVQNRQDAHGVTFLEFEYTIPVRFIFCTDMGYLFVGNRKGTTPQDTIVAAYQLFAG 384
            :|     |..::|.....| |.|:|.......|:..|:.|.:..|::..::   ..:..|.....
Zfish   453 KV-----PDDLKNVVATAG-TSLDFHKQKDHHFLVGTEAGKIHKGSKYYSS---KFLEMYDAHFM 508

  Fly   385 PIRCVMRNPFFVKNFLVVG-DWRVRIWSEEVKNCPSTFYFRRPNQLLSGAWSTGRCSLFCIGDNM 448
            .:.||..|||....|:..| ||.|:||...: |.| .|.|...:.:...|||....::|......
Zfish   509 TVSCVRWNPFHPNVFISCGWDWMVKIWDHTI-NSP-VFTFELKSSVTDVAWSPHSSTVFAAVTAD 571

  Fly   449 GNLEFWDLLMSHKRPIL---TIKYKYAVTHLVFKPDGTMLTVSLANGDCLMLRLEEGMRSATNKE 510
            |.:..:||.::....:.   .:..|..:.|:.|.|...::.|....|..:.|:|...:|....::
Zfish   572 GKVHVFDLSINKYEALCQQKVVSKKTRLLHIEFNPVHPIIIVGDDRGRVISLKLSPNLRKKPKEK 636

  Fly   511 KSLMMSMFEREIQRCKLLEAREEEI-KLKKRLTTI 544
            |..            :|.:..|.|| |:::.|:::
Zfish   637 KGQ------------ELPKGPEVEIAKMEQLLSSL 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	19/70 (27%)
		WD40	261..>512	CDD:225201	61/267 (23%)
		WD40	279..492	CDD:295369	55/227 (24%)
		WD40 repeat	284..332	CDD:293791	15/58 (26%)
		WD40 repeat	386..422	CDD:293791	14/36 (39%)
		WD40 repeat	429..454	CDD:293791	5/24 (21%)
dnai1.2	NP_001074027.1	WD40	<296..650	CDD:225201	93/413 (23%)
		WD40	354..620	CDD:295369	67/290 (23%)
		WD40 repeat	357..397	CDD:293791	10/39 (26%)
		WD40 repeat	405..485	CDD:293791	22/85 (26%)
		WD40 repeat	511..547	CDD:293791	15/37 (41%)
		WD40 repeat	552..591	CDD:293791	7/38 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810