DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10859 and dync2i2

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_012823678.1	Gene:	dync2i2 / 448417	XenbaseID:	XB-GENE-953027	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	491	Identity:	102/491 - (20%)
Similarity:	170/491 - (34%)	Gaps:	91/491 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SSVLTHNVTLDSHGLNHYEGGWNVKEVNIMDEESTMRYRKKVERDDSWGIEVNQLMHAAMDISSA 126
            |..:...||::|        .|...:.:..:.........|.:...:....|.: |....::::.
Frog     3 SDAVLEEVTVES--------AWRKSQESRCESRCCQTISLKAKEASNQACHVRE-MGTQTELNAN 58

  Fly   127 NNAVNIYEDFFVDLPEDLGR------GISMKIAARG--THVFHDL---WIPSRRLMTCEWLNNDP 180
            ...:::.....:|.| |||:      ||.:|...:.  :|.|...   |......:||......|
Frog    59 QRTLDVDLGPLLDYP-DLGQFLKRVEGIMIKELNKNWKSHAFDGYEVNWEEQHEQVTCLHSLQYP 122

  Fly   181 NQF--------LLFYSNRMSLTPDYTKQLNTLPDFGND--NPHAFYI--WNLDDATRPAAHYDSR 233
            :..        :.:.|....:...|.:       ||:.  :....|:  ||||.....|.:.|:.
Frog   123 DALEQQLQVTSVSWNSTGSIIACSYGR-------FGDGDWSTEKSYVCTWNLDRRGFNANNPDTV 180

  Fly   234 RVVRVAKVCL----RDESYMVGGLQEGQVGFWLTENQGGP--KSMCPLEACHREATTAICWVHSK 292
            ..|..:.:||    ...|.:.|||..|.|..|.|.....|  .....:...|.:|...:.|:..|
Frog   181 LDVPSSVMCLAWHPSQPSLIAGGLFNGDVLVWDTSRTDDPLIGRTGHVGDTHTDAVYQVGWMQEK 245

  Fly   293 L---NTEFYSGSLDGSIKYWDTRD----LLMPVHEVLAEPDPQTVQ----NRQD-AHGVTFLEFE 345
            .   ..:.:|.|.||.|..|....    :|:....::|:..|...:    .|.| |.|||.|.:.
Frog   246 SQGHRHQVFSVSSDGKILVWQMEKEGHLVLLDGFALVAQQIPSNTKIHKPGRGDTAVGVTCLSYS 310

  Fly   346 YTIPVRFIFCTDMGYLFVGNRKGTTPQDTIVA---------------AYQLFAGPIRCVMRNPFF 395
            :..|..||...:.|||.    |.::...|:..               .:....||:..|..:||.
Frog   311 HFDPSLFIVGVEGGYLL----KCSSSVQTLAPINMGSSVPLRAPAQFTFSPHGGPVYSVTCSPFH 371

  Fly   396 VKNFLVVG-DWRVRIWSEEVKNCPSTFYFRRPNQLLSGAWSTGRCSLFCIGDNMGNLEFWDLLMS 459
            ...||..| |....::| .::..|..........|.|..||..|..:|......|.:...|...|
Frog   372 RNLFLSAGTDGHAHLYS-MLQAKPLVSLQLSQKYLFSIRWSPVRPLVFAAASGDGEVVLVDFAKS 435

  Fly   460 HKRPILTIK------------YKYAVTHLVFKPDGT 483
            .::|.|.||            :.:|.:.|:...|||
Frog   436 FQKPSLCIKQTASGRPVYCLEFNHAQSQLLAAGDGT 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	18/69 (26%)
		WD40	261..>512	CDD:225201	60/265 (23%)
		WD40	279..492	CDD:295369	57/245 (23%)
		WD40 repeat	284..332	CDD:293791	11/58 (19%)
		WD40 repeat	386..422	CDD:293791	9/36 (25%)
		WD40 repeat	429..454	CDD:293791	7/24 (29%)
dync2i2	XP_012823678.1	WD40 repeat	131..182	CDD:293791	11/57 (19%)
		WD40	184..481	CDD:392136	68/293 (23%)
		WD40 repeat	188..227	CDD:293791	11/38 (29%)
		WD40 repeat	236..297	CDD:293791	11/60 (18%)
		WD40 repeat	305..355	CDD:293791	10/53 (19%)
		WD40 repeat	362..399	CDD:293791	9/37 (24%)
		WD40 repeat	405..446	CDD:293791	13/40 (33%)
		WD40 repeat	452..477	CDD:293791	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910