DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10859 and sw

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	100/477 - (20%)
Similarity:	180/477 - (37%)	Gaps:	81/477 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 KEVNIMDEESTMRYRKKV----ERDDSWGIEVNQLMHAAMDISSANNAVNIYEDFFVDLPEDLGR 146
            ||||.:.||     :|::    |....:.:...:::..|:   |.|  |:||.|:       :|.
  Fly   237 KEVNELSEE-----QKQMIILSENFQRFVVRAGRVIERAL---SEN--VDIYTDY-------IGG 284

  Fly   147 GISMKIAARGTH-------VFHD-LWIPSRRLMTCEWLNNDPNQFLLFYSNRMSLTPDYTKQLNT 203
            |.|.:.....:|       ||:| .|..:|.:.:.:|..:.|...:..|.|.
  Fly   285 GDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNN------------- 336

  Fly   204 LPDFGNDNPHAFYIWNL---DDATRPAAHYDSRRVVRVAKVCLR--DESYMVGGLQEGQVGFWLT 263
             .:..|:......:||.   ........|..|    .|...|..  :.:.::||...||:..|..
  Fly   337 -EESPNEPDGVVMVWNTKFKKSTPEDVFHCQS----AVMSTCFAKFNPNLILGGTYSGQIVLWDN 396

  Fly   264 ENQ-GGPKSMCPLE-ACHREATTAICWVHSKLNTEFYSGSLDGSIKYWDTRDLLMPVHEVLAEP- 325
            ..| ..|....||. |.|......:..|.::......|.|.||.:..|..        ::|::|
  Fly   397 RVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSL--------DMLSQPQ 453

  Fly   326 DPQTVQNRQD-AHGVTFLEFEYTIPVRFIFCTDMGYLFVGNRKGTTPQDTIVAAYQLFAGPIRCV 389
            |...:|.||. |..:|.:.|........:..::.||::..:|.|.  :..:...|:...|||..:
  Fly   454 DTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGL--RSGVNEVYERHLGPITGI 516

  Fly   390 -----MRNPFFVKNFLVVG-DWRVRIWSEEVKNCPSTFYFR-RPNQLLSGAWSTGRCSLFCIGDN 447
                 ..:|.|...||... ||.:::||  :|:....:.|. ..:.::..|||....:||...|.
  Fly   517 STHYNQLSPDFGHLFLTSSIDWTIKLWS--LKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDG 579

  Fly   448 MGNLEFWDLLMSHKRPI--LTIKYKYAVTHLVFKPDGTMLTVSLANGDCLMLRLEEGMRSATNKE 510
            .|.|:.|:|....:.|.  :.:....|:..:.:.|.|..:.:....|...:..:.|.:...:..|
  Fly   580 SGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDE 644

  Fly   511 KSLMMSMFEREIQRCKLLEARE 532
                .|.|...:...|:.::.|
  Fly   645 ----WSRFNTHLSEIKMNQSDE 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	16/66 (24%)
		WD40	261..>512	CDD:225201	57/263 (22%)
		WD40	279..492	CDD:295369	48/223 (22%)
		WD40 repeat	284..332	CDD:293791	9/48 (19%)
		WD40 repeat	386..422	CDD:293791	10/41 (24%)
		WD40 repeat	429..454	CDD:293791	8/24 (33%)
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922
		WD40	316..632	CDD:421866	70/345 (20%)
		WD40 repeat	316..365	CDD:293791	7/62 (11%)
		WD40 repeat	371..409	CDD:293791	8/37 (22%)
		WD40 repeat	418..457	CDD:293791	9/46 (20%)
		WD40 repeat	469..555	CDD:293791	19/89 (21%)
		WD40 repeat	561..599	CDD:293791	11/37 (30%)
		WD40 repeat	607..633	CDD:293791	3/25 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435291
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840