DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10859 and CG14838

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster

Alignment Length:	744	Identity:	132/744 - (17%)
Similarity:	254/744 - (34%)	Gaps:	219/744 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 DRNEMILSVQPSGRLRLKYILRNPINERTQLSEQYAASSVLTHNVTLDSHGLNHY-----EGGWN 84
            |..:.:|.:.|:..::.:.:.:..:|...|.:.........| |.|..|:..:.|     :....
  Fly   244 DVRDGVLELLPNENIKWENVTKKRVNVSVQSAPPKIEREQQT-NPTFPSNAWSQYLYEIDDEDLE 307

  Fly    85 VKEVNIMDEESTMRYRKKVERDDSWGIEVNQL---MHAAMDI---SSANNAVNIYEDFFVDLPED 143
            :.|.::.:||.    :||.:......:|..:.   |.|.:::   :...|.::.|.|.:
  Fly   308 LDETDVDEEEE----KKKAQAKPGTYVEPEKKPPEMSAQIEMLLNTLEFNQIDSYRDDY------ 362

  Fly   144 LGRGISMKIAARGTHVFHDLWIPSRRLMTCEWLNNDPNQFLLF----YSNRMSLTP-DYTKQLNT 203
                 |:              |.||:::  ::.|....:||.|    .||:..:.. |:..:|:.
  Fly   363 -----SL--------------ISSRQVV--QYTNPYLQEFLCFANISKSNKRFVAGYDWYPKLSG 406

  Fly   204 L---------PDFGND-------------NPHAFYIWNLDDATRPAAHYDSRRVVRVAKVCLRDE 246
            |         |...|:             .|:...:|:..|.......:::.........|..:.
  Fly   407 LIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPVLLWSFSDNLNYKLEFEAPIETTALTFCPFNG 471

  Fly   247 SYMVGGLQEGQVGFW-----------------------------------LTENQGGPKSMCPLE 276
            ..::||.:.|||..|                                   :.:|...|.::..|:
  Fly   472 DILLGGSKNGQVVLWDLQGRCEKLDEEEYLTAAQAKYRIMIGEFLNWTIDIEDNVIVPATISLLD 536

  Fly   277 ACHREATTAICWV--------------------HSKLNTEFYSGSLDGSIKYWD----------- 310
            ...:.|.||..|:                    |.|.   |.:.:.||:|.:||
  Fly   537 CSPKGAITAFYWLGRSIYLSQFGKVYNDPDIRNHHKF---FVTCAFDGTISFWDLDGKGGKSAKD 598

  Fly   311 -TRDLLMPVHEVLAE----------------PDPQT------------------VQNRQDAHGV- 339
             .|:.::|.....:|                |:|.|                  :|.....:.:
  Fly   599 KMRNRMLPKELTQSESAFKSMVIKPTYNLYFPEPITGIIADTSCLSCLTPVAKLIQANPSNYPIK 663

  Fly   340 TFLEFEYTIPVRFIFCTDMGYLFVGNRKGTTPQ-------DTIVAAYQLFAGPIRCVMRNPFFVK 397
            |..:...|:....|..|..|::...:.:||..:       ::.:....:..||:..|.:|||:.:
  Fly   664 TIAKDPPTMRQSMIVSTFYGHVSRIDWQGTYTEGEATEVINSSIPFAMVHDGPVVMVKKNPFYPE 728

  Fly   398 NFLVVGDWRVRIWSEEVKNCPSTFYFRRPNQLLSGAWSTGRCSLFCIGDNMGNLEFWDLLMSHKR 462
            .|..:|...:.||.|:....| .|:.:|...|.:.|||..|.::..:....|.||.||:|.....
  Fly   729 LFASIGRTILAIWKEDYNYSP-IFWRKRACDLTAVAWSETRPAVLYLTRIDGILEAWDILARDDD 792

  Fly   463 PILT-----------IKYKYAVTHLVFKPDGTMLTVSLANGDCLMLRLEEGMRSATNKEKSLMMS 516
            ..||           .:::.::.|.:       |.:...|....|::|..........|...::.
  Fly   793 ACLTEILGGGIITAITEHRPSLPHKI-------LGIGDYNSSIRMVKLPHSFDVPLPNELDQLIK 850

  Fly   517 MFEREIQR--------CKLLEAREEEIKLKKRLTT-IFLEEERKSREKLEAKKKKGQAKKEMEPK 572
            ...:|.:|        .|..|..::.|:.|:.... |..|.|:|.:|:..|.:||||...|...:
  Fly   851 YVLKEERRKMGIQSWEQKYYELNKDIIEAKREAAAEIRKEMEKKEKEEQLASRKKGQKSGEDGGE 915

  Fly   573 VEDEATIFLRMIESDSEFSKALLEFNEAM 601
            ..:|       |:....:|.  |.:||.|
  Fly   916 GGEE-------IKGKKNYSG--LNYNEKM 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	19/119 (16%)
		WD40	261..>512	CDD:225201	63/370 (17%)
		WD40	279..492	CDD:295369	55/297 (19%)
		WD40 repeat	284..332	CDD:293791	17/113 (15%)
		WD40 repeat	386..422	CDD:293791	10/35 (29%)
		WD40 repeat	429..454	CDD:293791	8/24 (33%)
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	46/300 (15%)
		WD40 repeat	462..505	CDD:293791	7/42 (17%)
		WD40 repeat	510..547	CDD:293791	6/36 (17%)
		RE_R_Pab1	807..>863	CDD:286594	8/62 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840