DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10859 and Dic61B

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_728477.1	Gene:	Dic61B / 38020	FlyBaseID:	FBgn0263988	Length:	764	Species:	Drosophila melanogaster

Alignment Length:	371	Identity:	74/371 - (19%)
Similarity:	120/371 - (32%)	Gaps:	104/371 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 YIWNLDDATRP--AAHYD--------SRRVVRVAKVCLRDESYM---VGGLQEGQVGFWLTENQG 267
            ::|::.:...|  |.:||        |..:..:..:.|.|.|..   |..||:..|.  :::...
  Fly   414 FLWSIKNPGEPERAYYYDVPVTAINFSPFLPSLLAIGLYDGSVEVRDVSSLQDTPVA--VSQRST 476

  Fly   268 GPKSMCPLEACHREATTAICWV-------HSKLNTEFYSGSLDGSIKYWDTRDLLMPVHEVLAEP 325
            .|.|         ....||.|:       |......|.|.|.|||:    ||      ..::..|
  Fly   477 SPGS---------SPVVAIRWIKQVSDDDHETDIDPFLSLSQDGSV----TR------FRIIKSP 522

  Fly   326 ----DPQTVQNRQDAH--GVTFLEFEYTIPVR-------------------FIFCTDMGYLFVGN 365
                ..|.:..|.:.|  |: |:.....||..                   :...||.|.:   :
  Fly   523 FLLGFTQMILERVEGHPEGI-FVHPSSRIPCESNRHPQGLSITTHPLHKDIYYVLTDEGCI---H 583

  Fly   366 RKGTTPQDTIVAAYQLFAGPIRCVMRNPFFVKNFLVVG-DWRVRIWSEEVKNCPSTFYFRRP-NQ 428
            :.....|...:...:...|.:..:..:|:..|.||..| ||.||||.:.:         .|| .:
  Fly   584 KCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFLTCGNDWFVRIWVDGI---------TRPLLE 639

  Fly   429 LLS-------GAWSTGRCSLFCIGDNMGNLEFWDLLMSHKRPILTIKYKYAVTHLV-FKPDGTML 485
            ||.       ..||... |...:..|......||...:..||:...|...:...:. |...|..|
  Fly   640 LLDEMTPVHWAKWSPTH-STIIVTVNRETANVWDFRRNLLRPMSKHKMDSSFNTVARFSHCGRTL 703

  Fly   486 TVSLANGDCLML--------------RLEEGMRSATNKEKSLMMSM 517
            .:....|:.|..              .||:.:..|...:..|:|.:
  Fly   704 VIGNERGNTLFNALNDMPFSPHFQYDELEKAIFKAIGNDHELLMEL 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	18/74 (24%)
		WD40	261..>512	CDD:225201	59/306 (19%)
		WD40	279..492	CDD:295369	52/254 (20%)
		WD40 repeat	284..332	CDD:293791	14/58 (24%)
		WD40 repeat	386..422	CDD:293791	11/36 (31%)
		WD40 repeat	429..454	CDD:293791	6/31 (19%)
Dic61B	NP_728477.1	WD40	358..730	CDD:225201	69/350 (20%)
		WD40 repeat	381..429	CDD:293791	3/14 (21%)
		WD40	433..711	CDD:295369	62/312 (20%)
		WD40 repeat	434..473	CDD:293791	8/40 (20%)
		WD40 repeat	552..599	CDD:293791	4/49 (8%)
		WD40 repeat	604..637	CDD:293791	12/41 (29%)
		WD40 repeat	645..682	CDD:293791	8/37 (22%)
		WD40 repeat	691..727	CDD:293791	5/35 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840