DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10859 and CG15701

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_611100.1	Gene:	CG15701 / 36801	FlyBaseID:	FBgn0034095	Length:	1051	Species:	Drosophila melanogaster

Alignment Length:	707	Identity:	129/707 - (18%)
Similarity:	229/707 - (32%)	Gaps:	218/707 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 ILSRERRRFGRQCLFTDRNEMILSVQP---------SGRLRLKYI---LRNP-INERTQLSEQYA 60
            ::||.......:..|...|..:..::|         .|:|....:   .::| ::...|..|.::
  Fly   380 VISRRGEELMAKLRFDQLNYHLFEMKPLSYEGFMQSYGKLNASQVATQTQSPHMDGECQTLEVHS 444

  Fly    61 ASSVLTHNVTLDSHGLNHYEGGWNVKEVNIMDEESTMRYRKKVERDDSWGIEVNQLMHAAMDISS 125
            .||...|.        .|| ||..|...::           ..|.|::|..:......|     |
  Fly   445 RSSWTQHP--------PHY-GGQFVLSCSV-----------DAELDETWSKQPADEYEA-----S 484

  Fly   126 ANNAVNIYEDFFVDLPEDLGRGISMKIAARGTHV--FHDLWIPSRRLM--------TCEWLNNDP 180
            .:....::.     |.:...:.:..|..|:.|.:  .:.....:.|||        |.....|.|
  Fly   485 ISRLEQLHR-----LEQARSQQLQQKRLAKSTDLERLNSFLHRAGRLMGLVLEGKTTAHGQGNSP 544

  Fly   181 NQFLLFYSNRMSLTPDYTKQLNTLP------DFGN-------------------DNPHAFYIWNL 220
            ..           .|..|..||.||      ..||                   |......:|:|
  Fly   545 RN-----------VPLQTGLLNALPVRRIFGSAGNGQLVVTVHECPADSNVYKEDFASLLMVWSL 598

  Fly   221 DDATRPAAHYDS-RRVVRVAKVCLRDESYMVGGLQEGQVGFW-LTENQGGPKSMCPLEACHREAT 283
            .:.::|.....: ..|.||| :..:.:..:|.||::|.|..| |.|
  Fly   599 ANPSQPLRLLSTWAEVSRVA-LSAQAQDIVVAGLRDGSVAMWDLRE------------------- 643

  Fly   284 TAICWVHSKLNTEFYSGSLDGSIKYWDTRDLLMPVHE----------VLAEPDPQTVQNRQDAHG 338
                       |..|...|||.:.::.....::|:.|          :.|..|.::.::..:|.|
  Fly   644 -----------THSYCSKLDGHLTHFAATQSVVPMPEQQDKEVNAMDLGAVVDVRSFRSHLNAGG 697

  Fly   339 V--------TFLEFEYTIPVRFIFCTDMGYL----FVGNRKGTTPQDTIVAAYQLFAGPIRCVMR 391
            |        |:.|.:|.      ...|.|.|    .|.....|...:        |:.|
  Fly   698 VAATSGLQTTYKEVQYA------SLNDSGLLTMWTLVEGASSTNSNE--------FSSP------ 742

  Fly   392 NPFFVKNFLVVGDW-RVRIWSEEVKNCPSTFYFRRPNQLL---SGAWSTGRCSLFCIGDNMGNLE 452
                         | ||::.  :..:|....|..|  :||   ..|:...: |||     .||:.
  Fly   743 -------------WARVKLL--QSGSCDLRSYLER--RLLKSHQSAYEKTK-SLF-----QGNIY 784

  Fly   453 FWDLL--MSHKRPILTIKYKYAVTHLVFK--PDGTMLTVSLANGDCLM-----LRLEEGMRSATN 508
            ..|:|  ::..:.:.|......:..|.|.  ..|:.|.....|.:.::     |:.|...|.|.|
  Fly   785 SDDVLRELNDTQTLTTALQGQGLQGLRFTSIDTGSELIYVCTNRNFVLCCTRSLKTERFARIAVN 849

  Fly   509 KEKSLMMSMFEREIQRCKLLEAREEEIKLKKRLTTIF-LEEERKSREKLEAKKKKG--QAKKEME 570
            :.:.|..:..      |.|.......:.|......|. ..:.::.|::.:.:.|.|  .|..|.:
  Fly   850 ESRFLFPTSL------CVLSNENYVAVGLSNGSVMILNCNQRQRQRQRNQQRPKTGLPPATDEPD 908

  Fly   571 PKVEDEATIFLRMIESDSEFSKALLEFN---EAMENVA---IQRSKRTFAMERTVFE 621
            |:......|...::.....|.:. ::.|   :|..|.|   |:|.:|::.|.  ||:
  Fly   909 PETGKSCAIQNIILNERRSFDQQ-MDDNPTYDARPNTALELIERPRRSYEMR--VFD 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	13/65 (20%)
		WD40	261..>512	CDD:225201	52/286 (18%)
		WD40	279..492	CDD:295369	43/242 (18%)
		WD40 repeat	284..332	CDD:293791	9/57 (16%)
		WD40 repeat	386..422	CDD:293791	4/36 (11%)
		WD40 repeat	429..454	CDD:293791	8/27 (30%)
CG15701	NP_611100.1	PTZ00108	<23..270	CDD:240271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000