DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10859 and DNAI1

DIOPT Version :9

Sequence 1:NP_001285898.1 Gene:CG10859 / 34756 FlyBaseID:FBgn0032520 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_001268357.1 Gene:DNAI1 / 27019 HGNCID:2954 Length:703 Species:Homo sapiens


Alignment Length:361 Identity:75/361 - (20%)
Similarity:138/361 - (38%) Gaps:46/361 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   206 DFGNDNPHAFYIWNLDDATRPAAHYDSRRVVRVAKVCLR---DESYMVG-GLQEGQVGFWLTENQ 266
            ||...:.....:::|.:.:.|...:.|...|    :||.   |..|:|. |..:|.|..:..:..
Human   360 DFMKQSRGMLLLYSLKNPSFPEYMFSSNSGV----MCLDIHVDHPYLVAVGHYDGNVAIYNLKKP 420

  Fly   267 GGPKSMC--PLEACHREATTAICWVHSKL--NTEFYSGSLDGSIKYWD--TRDLL-MPVHEVLAE 324
            ....|.|  .....|.:....:.|....:  |..|:|.|.||.|..|.  .|.|: :.|.::..|
Human   421 HSQPSFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVE 485

  Fly   325 PDPQTVQNRQDAHGV---TFLEFEYTIPVRFIFCTDMGYLFVGNRKGTTPQDTIVAAYQLFAGPI 386
            .....|......|.|   |..:|...|...|:..|:.|.::..::..::   ..:..|......:
Human   486 GSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSS---QFLDTYDAHNMSV 547

  Fly   387 RCVMRNPFFVKNFL-VVGDWRVRIWSEEVKNCPSTFYFRRPNQLLSGAWSTGRCSLFCIGDNMGN 450
            ..|..||:..|.|: ...||.|:||...:|.  ..|.:...:.:...||:....::|......|.
Human   548 DTVSWNPYHTKVFMSCSSDWTVKIWDHTIKT--PMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGK 610

  Fly   451 LEFWDLLMSH-----KRPILTIKYKYAVTHLVFKPDGTMLTVSLANGDCLMLRLEEGMRSATNKE 510
            ...:||.::.     .:|:...|.:  :||:.|.....::.|....|..:.|:|...:|....::
Human   611 AHIFDLAINKYEAICNQPVAAKKNR--LTHVQFNLIHPIIIVGDDRGHIISLKLSPNLRKMPKEK 673

  Fly   511 KSLMMSMFEREIQRCKLLEARE--------EEIKLK 538
            |.       :|:|:...:|..:        .|:|:|
Human   674 KG-------QEVQKGPAVEIAKLDKLLNLVREVKIK 702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10859NP_001285898.1 WD40 <245..310 CDD:295369 17/69 (25%)
WD40 261..>512 CDD:225201 54/266 (20%)
WD40 279..492 CDD:295369 48/226 (21%)
WD40 repeat 284..332 CDD:293791 14/52 (27%)
WD40 repeat 386..422 CDD:293791 11/36 (31%)
WD40 repeat 429..454 CDD:293791 4/24 (17%)
DNAI1NP_001268357.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..54
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..174
WD40 324..681 CDD:225201 71/338 (21%)
WD 1 324..374 2/13 (15%)
WD40 repeat 339..385 CDD:293791 4/24 (17%)
WD40 <357..615 CDD:295369 56/263 (21%)
WD 2 379..417 11/41 (27%)
WD40 repeat 391..428 CDD:293791 9/36 (25%)
WD 3 426..469 11/42 (26%)
WD40 repeat 439..496 CDD:293791 14/56 (25%)
WD 4 478..530 11/51 (22%)
WD40 repeat 504..541 CDD:293791 6/39 (15%)
WD 5 535..574 11/38 (29%)
WD40 repeat 547..584 CDD:293791 12/38 (32%)
WD 6 578..616 5/39 (13%)
WD40 repeat 589..616 CDD:293791 4/26 (15%)
WD 7 622..662 8/41 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1587
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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