DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10859 and SdicC

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001303578.1	Gene:	SdicC / 26067076	FlyBaseID:	FBgn0283434	Length:	544	Species:	Drosophila melanogaster

Alignment Length:	473	Identity:	96/473 - (20%)
Similarity:	172/473 - (36%)	Gaps:	90/473 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 KEVNIMDEESTMRYRKKV----ERDDSWGIEVNQLMHAAMDISSANNAVNIYEDFFVDLPEDLGR 146
            ||||.:.||     :|::    |....:.:...:::..|:   |.|  |:||.|:       :|.
  Fly   117 KEVNELSEE-----QKQMIILSENFQRFVVRAGRVIERAL---SEN--VDIYTDY-------IGG 164

  Fly   147 GISMKIAARGTH-------VFHD-LWIPSRRLMTCEWLNNDPNQFLLFYSNRMSLTPDYTKQLNT 203
            |.|.:.....:|       ||:| .|..:|.:.:.:|..:.|...:..|.|.
  Fly   165 GDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPKLVVGSYHNN------------- 216

  Fly   204 LPDFGNDNPHAFYIWNL---DDATRPAAHYDSRRVVRVAKVCLR--DESYMVGGLQEGQVGFWLT 263
             .:..|:......:||.   ........|..|    .|...|..  :.:.::||...||:..|..
  Fly   217 -EESPNEPDGVVMVWNTKFKKSTPEDVFHCQS----AVMSTCFAKFNPNLILGGTYSGQIVLWDN 276

  Fly   264 ENQ-GGPKSMCPLE-ACHREATTAICWVHSKLNTEFYSGSLDGSIKYWDTRDLLMPVHEVLAEP- 325
            ..| ..|....||. |.|......:..|.::......|.|.||.:..|..        ::|::|
  Fly   277 RVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSL--------DMLSQPQ 333

  Fly   326 DPQTVQNRQD-AHGVTFLEFEYTIPVRFIFCTDMGYLFVGNRKGTTPQDTIVAAYQLFAGPIRCV 389
            |...:|.||. |..:|.:.|........:..::.||::..:|.|.  :..:...|:...|||..:
  Fly   334 DTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGL--RSGVNEVYERHLGPITGI 396

  Fly   390 -----MRNPFFVKNFLVVGDWRVRIWSEEV--------------KNCPSTFYFRRPNQLLSGAWS 435
                 ..:|.|...||...   ::|||.::              .|.|...:....:.::..|||
  Fly   397 STHYNQLSPDFGHLFLTSS---IKIWSLKLPISSCQFSVVSGINSNKPLYSFEDNSDYMMDVAWS 458

  Fly   436 TGRCSLFCIGDNMGNLEFWDLLMSHKRPI--LTIKYKYAVTHLVFKPDGTMLTVSLANGDCLMLR 498
            ....:||...|..|.|:.|:|....:.|.  :.:....|:..:.:.|.|..:.:....|...:..
  Fly   459 PVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYD 523

  Fly   499 LEEGMRSATNKEKSLMMS 516
            :.|.:...:..|..:..|
  Fly   524 VAENLAQPSRDEIKMNQS 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	16/66 (24%)
		WD40	261..>512	CDD:225201	56/275 (20%)
		WD40	279..492	CDD:295369	47/235 (20%)
		WD40 repeat	284..332	CDD:293791	9/48 (19%)
		WD40 repeat	386..422	CDD:293791	10/54 (19%)
		WD40 repeat	429..454	CDD:293791	8/24 (33%)
SdicC	NP_001303578.1	Dynein_IC2	23..51	CDD:288403
		NtpH	108..>178	CDD:225368	19/77 (25%)
		WD40	196..523	CDD:295369	69/357 (19%)
		WD40 repeat	196..245	CDD:293791	7/62 (11%)
		WD40	<224..534	CDD:225201	65/326 (20%)
		WD40 repeat	251..289	CDD:293791	8/37 (22%)
		WD40 repeat	298..337	CDD:293791	9/46 (20%)
		WD40 repeat	349..386	CDD:293791	6/38 (16%)
		WD40 repeat	393..446	CDD:293791	10/55 (18%)
		WD40 repeat	452..491	CDD:293791	11/38 (29%)
		WD40 repeat	498..522	CDD:293791	3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435289
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940