DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10859 and DNAI3

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_660155.2	Gene:	DNAI3 / 126820	HGNCID:	30711	Length:	891	Species:	Homo sapiens

Alignment Length:	759	Identity:	147/759 - (19%)
Similarity:	254/759 - (33%)	Gaps:	248/759 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FILSRERRRFGRQCLFTDRNEMIL-------SVQPSGRLRLKYILRN----PINERTQLSEQYAA 61
            :::||:|..||....|:|:|...:       :..|.....||.:.::    .|.:...:|.|  .
Human   183 YMISRKRSEFGAPIKFSDQNASSVKDAYIECTAYPDKNFTLKQLEKDVGMQVIPQIKDISTQ--T 245

  Fly    62 SSVLTHNVTLDSHGLNHYEGGWNVKEVNIMDEESTMRYRKKVERDDSWGIEVNQLMHAAMDISSA 126
            ......|.|...:.....|           :|:.|::..|.:         |:.|.:|::.:..|
Human   246 KWTYPKNATTQYYPREFSE-----------EEKETLKQSKPL---------VDFLNNASISVEIA 290

  Fly   127 ---NNAVNIYEDFFVDLPEDLGR-GISMKIAARGTHVFHDLWIPSRRLMTC-EWLNNDPNQF--- 183
               |..:|.:.|.:..|.|:.|. |.......:....|.||..|:.:::|| .|   .|..:
Human   291 LQQNEIMNTFIDDWKYLAEEEGTFGDKTDTHLKEYQSFTDLHSPTEKMITCVSW---HPTIYGLI 352

  Fly   184 ------LLFYSNRMSLTPDYTKQLNTLPDFGNDNPHAFYIWNLDDATRPAAHYDSRRVVRVAKVC 242
                  .|.:.:|:..:.....|           |.....|:..|...|....:|...:...|.|
Human   353 AVSVAVRLSFEDRVHFSGKLLLQ-----------PSLILFWSFSDPIHPQLMLESPDDIFCFKFC 406

  Fly   243 LRDESYMVGGLQEGQVGFW-LT------EN--QGGPKS--------------------------M 272
            ..|.:.:.||...||:..| :|      ||  .||.:|                          :
Human   407 PSDPNIIAGGCINGQIVMWDITAHADRIENIKAGGSRSKRATLKPMFLLEPESNKEAMYIRHCAV 471

  Fly   273 CPLEACHREATTAICWV---------------HSKLNTEFYSGSLDGSIKYWDTRDLLMPVHEVL 322
            ..:|..|::..|.|.|:               .|.:..:..:.|.|.:|.:||.|.
Human   472 SSIENGHKKVITDIHWLSDTFEINRMGSVFENRSGICCQLVTCSADCTICFWDIRP--------- 527

  Fly   323 AEP-DPQTVQNRQDAHGVTFLEFEYTIPVRFI--------------------------------- 353
            .:| .|||.:.:::..    :|..:.:|..|:
Human   528 QKPLTPQTTEKKKEES----IEIPFDVPSTFLHLDLSWKPLTKVRLSKGETSLDHCPTKISLNED 588

  Fly   354 -----------------------------------------FCTDMGYLFVGNRKGTT------- 370
                                                     |||.   .|||..:|..
Human   589 HLLCKTQDKMLAQSKTEKAEEMNPYHNLESGMANLLKPIDDFCTK---FFVGTEEGEVIYTDWKM 650

  Fly   371 ---PQ------DTIVAAYQLFAGPIRCVMRNPFFVKNFLVVGDWRVRIWSEEVKNCPSTFYFRRP 426
               |:      ...|:.:.:..|.:..:.|:||:....|.||.|.|.||.|.|...|.......|
Human   651 EKDPETGRLMSKKPVSHHTIHDGTVHTIQRSPFYNDIILTVGGWNVAIWKEGVMTGPLLQSCCAP 715

  Fly   427 NQLLSGAWSTGRCSLFCIGDNMGNLEFWDLLMSHKRP-------ILTIKYKYAVTHLVFKPDGTM 484
            .:..||.||..|..:|.||...|.::.||||.....|       |..|.|   :...:|......
Human   716 KRYTSGHWSLTRPGVFYIGREDGYIDIWDLLEKTHEPAQSQNICITMITY---IKPWIFSSKQQF 777

  Fly   485 LTVSLANGDCLMLRLEEGMRSATNKEKSLMMSMFEREI-------QRCKLLEAREEEIKL---KK 539
            :..:...|...:|.:...:...:..|.:.:...||||:       ||.|:.|..::|::|   ||
Human   778 IATADYYGTLHILEIPWTLSRPSTNEMASVNHYFEREVKHLEYVEQRKKIREQEKKEMELEMAKK 842

  Fly   540 RLTTIFLEEERKSREKLEAKKKKGQAKKEMEPKVEDEATIFLRM 583
            ::.|.     :||:|:::|     :.|.:.|..:|.|.|:.:.:
Human   843 KVKTY-----QKSKEQMQA-----ELKMDYESYLELEKTVLINL 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	21/114 (18%)
		WD40	261..>512	CDD:225201	71/398 (18%)
		WD40	279..492	CDD:295369	60/325 (18%)
		WD40 repeat	284..332	CDD:293791	14/63 (22%)
		WD40 repeat	386..422	CDD:293791	13/35 (37%)
		WD40 repeat	429..454	CDD:293791	9/24 (38%)
DNAI3	NP_660155.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		WD40	197..>531	CDD:225201	68/378 (18%)
		WD40	370..793	CDD:225201	83/452 (18%)
		WD 1. /evidence=ECO:0000255	395..435		10/39 (26%)
		WD 2. /evidence=ECO:0000255	477..533		12/64 (19%)
		WD 3. /evidence=ECO:0000255	670..709		14/38 (37%)
		WD 4. /evidence=ECO:0000255	713..753		14/39 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810