DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10859 and dnai2b

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_005156459.1	Gene:	dnai2b / 101884977	ZFINID:	ZDB-GENE-131016-1	Length:	604	Species:	Danio rerio

Alignment Length:	625	Identity:	197/625 - (31%)
Similarity:	302/625 - (48%)	Gaps:	49/625 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FILSRERRRFGRQCLFTDR-NEMILSVQPSGRLRLKYILRNPINERTQLSEQYAASSVLTHNVTL 71
            ::.:::|..|||||.|:|| .|:.:.:.|...|...:.:|:|.|...|.:::.:...|.|.....
Zfish     5 YVYTKKRSEFGRQCNFSDRPAELHVDILPDSSLAANFTVRDPCNVTIQCADEMSEHEVNTERFES 69

  Fly    72 DSHGLNHYEGGWNVKEVNIMDEESTMRYRKKVERDDSWGIEVNQLMHAAMDISSANNAVNIYEDF 136
            :|.|:||.|||| .|::|..|.|:|:|||||||:|:.:...:.|:..........|||.:|||||
Zfish    70 ESRGINHVEGGW-PKDLNPDDMEATIRYRKKVEKDEHYQNTIMQIAGLMEHCIRQNNATDIYEDF 133

  Fly   137 FVDLPEDLGRGISMKIAARGTHVFHDLWIPSRRLMTCEWLNNDPNQFLLFYSNRMSLTPDYTKQL 201
            ..|..|:.......:.:|:..:||.|.....|...:..|..:..::..:.||         :.:.
Zfish   134 LEDEDEEDVEESEEQPSAKTINVFRDPNEVKRTATSLSWHPDGNHKLAVAYS---------SLEF 189

  Fly   202 NTLPDFGNDNPHAFYIWNLDDATRPAAHYDSRRVVRVAKVCL----RDESYMVGGLQEGQVGFWL 262
            ...|   ||.....|||::::..:|  ....:.|..:  |||    :|...::||...||:.:|.
Zfish   190 QRAP---NDMNFDSYIWDIENPNKP--EMTLKPVCPL--VCLEYNPKDSHILIGGSYNGQIAYWD 247

  Fly   263 TENQGGPKSMCPLEACHREATTAICWVHSKLNTEFYSGSLDGSIKYWDTRDLLMPVHEVLAEPDP 327
            |.....|..|.|:|..||:......|:.||..|:.:|.|.||.:.:||.|.:..|...::.  ||
Zfish   248 TRKGSQPVEMSPIEFSHRDPVYKAIWLQSKTGTDIFSASTDGQVLWWDIRKMSEPTERLVM--DP 310

  Fly   328 QTVQNRQDAHGVTFLEFEYTIPVRFIFCTDMGYLFVGNRKGTTPQDTIVAAYQLFAGPIRCVMRN 392
            ....|..::.|...||||.|:|.:|:..|:.|.:...|||..||.:.||..|....||:..:.||
Zfish   311 TKKGNIDNSLGAISLEFETTMPTKFMVGTEQGLVVSCNRKAKTPAEKIVCTYSGHHGPVYALQRN 375

  Fly   393 PFFVKNFLVVGDWRVRIWSEEVKNCPSTFYFRRPNQLLSGAWSTGRCSLFCIGDNMGNLEFWDLL 457
            |||.||||.||||..|||||::|.....:.......||.|.||..|.|:|......|.|:.||:|
Zfish   376 PFFPKNFLTVGDWTARIWSEDIKESSIMWTKYHIAHLLDGCWSPVRPSVFFTVKMDGTLDVWDIL 440

  Fly   458 MSHKRPILTIKY-KYAVTHLVFKPDGTMLTVSLANGDCLMLRLEEGMRSATNKEKSLMMSMFERE 521
            .....|.|.:|. ..|:..:..:.:|..|......|...:|.:..|:.|....||:|:..|||||
Zfish   441 FKQNDPTLCLKVCDEALYSIKVQDNGRFLACGSQLGTTTLLEISSGLCSLQKNEKALVSEMFERE 505

  Fly   522 IQRCKLLEAREEEIKLKKRLTTIFLEEERKSREKLEAKKKKG-QAKKEMEPKVEDEATIFLRMIE 585
            .:|.|:||||..|::||:|      ....:|||. |.|:..| ::.:|:..:.|.|   |..:||
Zfish   506 TKREKILEARHREMRLKER------SRSEQSRED-EMKETDGEESVEELVARAEKE---FFHIIE 560

  Fly   586 S----------DSEFSKALLE---FNEAMENVAIQRSKRT 612
            :          |.:..|.:.|   |.|..|...:....||
Zfish   561 NERMKERNEEKDKDQEKGVCEEKDFQEEHETNGVSSFVRT 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	21/64 (33%)
		WD40	261..>512	CDD:225201	86/251 (34%)
		WD40	279..492	CDD:295369	75/213 (35%)
		WD40 repeat	284..332	CDD:293791	14/47 (30%)
		WD40 repeat	386..422	CDD:293791	19/35 (54%)
		WD40 repeat	429..454	CDD:293791	10/24 (42%)
dnai2b	XP_005156459.1	WD40	<168..495	CDD:225201	104/344 (30%)
		WD40 repeat	169..215	CDD:293791	10/59 (17%)
		WD40 repeat	221..260	CDD:293791	12/40 (30%)
		WD40	223..477	CDD:295369	88/255 (35%)
		WD40 repeat	268..296	CDD:293791	9/27 (33%)
		WD40 repeat	318..354	CDD:293791	13/35 (37%)
		WD40 repeat	369..409	CDD:293791	19/39 (49%)
		GBP_C	<489..588	CDD:303769	35/108 (32%)
		coiled coil	567..578	CDD:293879	1/10 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582441
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217312at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2212
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950