DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10859 and dnai2

DIOPT Version :9

Sequence 1:	NP_001285898.1	Gene:	CG10859 / 34756	FlyBaseID:	FBgn0032520	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	XP_031750209.1	Gene:	dnai2 / 100495747	XenbaseID:	XB-GENE-854694	Length:	593	Species:	Xenopus tropicalis

Alignment Length:	601	Identity:	187/601 - (31%)
Similarity:	293/601 - (48%)	Gaps:	64/601 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FILSRERRRFGRQCLFTDR-NEMILSVQPSGRLRLKYILRNPINERTQLSEQYAASSVLTHNVTL 71
            ::.:|:|..|||||.|:|| .|:.:.:.|.....|.:|.|||.:...|.|.:.:...|.|....:
Frog    11 YVYTRKRSEFGRQCNFSDRPAELHVDILPDPSQALNFIERNPCDVAIQCSHEMSEHEVNTERYEM 75

  Fly    72 DSHGLNHYEGGWNVKEVNIMDEESTMRYRKKVERDDSWGIEVNQLMHAAMDISSANNAVNIYEDF 136
            ::.|:||.|||| .|::|..:.|.|:|:|||||:||.:...::||..........|||:||||::
Frog    76 EARGINHVEGGW-PKDINPQEMEQTIRFRKKVEKDDHYIATISQLGSVMEHCIKQNNAINIYEEY 139

  Fly   137 FVDLPEDLGRGISMKIAARGTHVFHDLWIPSRRLMTCEWLNNDPNQFLLFYSNRMSLTPDYTKQL 201
            |.| .|:| .|:....:|...:||                 .|||: :...:..:|..||.:::|
Frog   140 FED-TEEL-EGMDETPSANTVNVF-----------------RDPNE-IKRTATHLSWHPDGSRKL 184

  Fly   202 ---NTLPDF---GNDNPHAFYIWNLDDATRPAAHYDSRRVVRVAKVCL----RDESYMVGGLQEG 256
               .:..||   ..|..:..|||:::...:|.........:    |||    :|...:|||...|
Frog   185 AVAYSCLDFQRAPKDMSYESYIWDIEIPNKPELTLKPVSPL----VCLEYNPKDSHVLVGGCYNG 245

  Fly   257 QVGFWLTENQGGPKSMCPLEACHREATTAICWVHSKLNTEFYSGSLDGSIKYWDTRDLLMPVHEV 321
            |:.:|.|...|.|.....:|..||:....:.|:.||..||.:|.|.||.|.:||.|.|..|..::
Frog   246 QIAYWDTRKGGNPMESTVIEHSHRDPVYKVIWLQSKTGTECFSASTDGQILWWDIRKLSEPTEKL 310

  Fly   322 LAEPDPQTVQNRQDAHGVTFLEFEYTIPVRFIFCTDMGYLFVGNRKGTTPQDTIVAAYQLFAGPI 386
            :.  |....:|..:|.|...||||.|:|.:|:..|:.|.:...|||..||.:.||..|....|||
Frog   311 IL--DISKKENLDNALGAVSLEFEPTLPTKFMVGTEQGMIVSCNRKAKTPPEKIVCTYGGHHGPI 373

  Fly   387 RCVMRNPFFVKNFLVVGDWRVRIWSEEVKNCPSTFYFRRPNQLLSGAWSTGRCSLFCIGDNMGNL 451
            ..:.||||:.||||.||||..|||||:.:.....:.....:.|....||..|.::|......|.|
Frog   374 YSIQRNPFYPKNFLTVGDWTARIWSEDCRESSIMWTKYHMSYLTDACWSPTRPTVFLTTKMDGTL 438

  Fly   452 EFWDLLMSHKRPILTIKYK----YAVTHLVFKPDGTMLTVSLANGDCLMLRLEEGMRSATNKEKS 512
            :.||.:.....|.|::|..    |::.   .:.:|..:......|...::.|.:|:.:....|::
Frog   439 DVWDYMYKQNNPSLSVKVSGEPLYSIR---MQDNGRFVACGSQMGVTTLMELSKGLYTLQRNERN 500

  Fly   513 LMMSMFEREIQRCKLLEAREEEIKLKKR-----------------LTTIFLEEERKSREKLEAKK 560
            |..:|||||.:|.|:||||..|::||:|                 :..|....|:...|.:||:.
Frog   501 LASAMFERETKREKILEARHREMRLKERSKAEPGEEVKEEKPAEDMNEIIANAEKDFFEIIEAEL 565

  Fly   561 KKGQAKKEMEPKVEDE 576
            |:.:.::..:|  |||
Frog   566 KRKEQQERKQP--EDE 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10859	NP_001285898.1	WD40	<245..310	CDD:295369	23/64 (36%)
		WD40	261..>512	CDD:225201	81/254 (32%)
		WD40	279..492	CDD:295369	72/216 (33%)
		WD40 repeat	284..332	CDD:293791	16/47 (34%)
		WD40 repeat	386..422	CDD:293791	18/35 (51%)
		WD40 repeat	429..454	CDD:293791	7/24 (29%)
dnai2	XP_031750209.1	WD40 repeat	105..141	CDD:293791	14/35 (40%)
		WD40	<172..495	CDD:225201	100/331 (30%)
		WD40 repeat	172..221	CDD:293791	11/48 (23%)
		WD40 repeat	226..265	CDD:293791	13/38 (34%)
		WD40 repeat	273..314	CDD:293791	15/42 (36%)
		WD40 repeat	326..367	CDD:293791	16/40 (40%)
		WD40 repeat	373..409	CDD:293791	18/35 (51%)
		WD40 repeat	416..441	CDD:293791	7/24 (29%)
		tolA_full	<509..>593	CDD:274303	21/73 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217312at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12442
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2212
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.110