DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG7099 and GTF3C1

DIOPT Version :9

Sequence 1:NP_609648.1 Gene:CG7099 / 34753 FlyBaseID:FBgn0032517 Length:1906 Species:Drosophila melanogaster
Sequence 2:NP_001511.2 Gene:GTF3C1 / 2975 HGNCID:4664 Length:2109 Species:Homo sapiens


Alignment Length:2303 Identity:499/2303 - (21%)
Similarity:840/2303 - (36%) Gaps:656/2303 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 INAIYDEVALEGLEGVTLPYLWDLLARRLEFFPSPLPDRIREQTWTLLLRTPPHKIEFFELPAER 74
            :.::.||||||||:|:.||.||..|..|:..||.||....:|..|..|...|  .|.|:|.|.||
Human     4 LESLLDEVALEGLDGLCLPALWSRLETRVPPFPLPLEPCTQEFLWRALATHP--GISFYEEPRER 66

  Fly    75 PLMPYYDRLNDIDEQLGL------PVVPEQCPYMLFPAAYVQEG--DIKGNCNDFKTRKLIPSSD 131
            |.:...||..:||.:.|:      ||..|.    ::|...:.|.  .|:|:|..||.||.| ::|
Human    67 PDLQLQDRYEEIDLETGILESRRDPVALED----VYPIHMILENKDGIQGSCRYFKERKNI-TND 126

  Fly   132 LHS------LNAAQATEQWAGRLVVVASQELRETALTPESLLMPKNLPLPNYIFLEAIGRSRYSG 190
            :.:      ....:|.::|..:|::||||.:|..||..:.......||..:|..||.:||||:.|
Human   127 IRTKSLQPRCTMVEAFDRWGKKLIIVASQAMRYRALIGQEGDPDLKLPDFSYCILERLGRSRWQG 191

  Fly   191 ------HTTAGPWSLINYSKDTGILFY-----IKNKLINLQLIIAQNYNEINKGRILVSSLLMLP 244
                  ||||       :..|.|.|.|     .||.||.:|..:.:    :..|....|.||:|.
Human   192 ELQRDLHTTA-------FKVDAGKLHYHRKILNKNGLITMQSHVIR----LPTGAQQHSILLLLN 245

  Fly   245 RFYRIYKNHSQENLEKLYLGIMRTPSRQVPVTEITDLLGRPTNFKTKKLLVTHSFRKFFE----- 304
            ||:...::.....:|||.:.:....:....:.::.:.||          |...:|::.::     
Human   246 RFHVDRRSKYDILMEKLSVMLSTRTNHIETLGKLREELG----------LCERTFKRLYQYMLNA 300

  Fly   305 --TKQVE---RPVAPLTKSGKQSKATTRKVTVIQLRNPDMQLKDLYKN--DDSEDNQVSEFLDLG 362
              .|.|.   :.:.|.....|..|.|...|..::|      ||:..:|  ||.||.:|..     
Human   301 GLAKVVSLRLQEIHPECGPCKTKKGTDVMVRCLKL------LKEFKRNDHDDDEDEEVIS----- 354

  Fly   363 HCFLDMPPEEEVFR---------AVARFGKRGLNSNELCHYTGINATYMRHFVKRVKKHGLVKEY 418
               ..:||.:.||.         .:.|.|.:|::..|:.....:.....|...:.:::..:||.:
Human   355 ---KTVPPVDIVFERDMLTQTYDLIERRGTKGISQAEIRVAMNVGKLEARMLCRLLQRFKVVKGF 416

  Fly   419 SEQVGKSRQFRFVA--VGHLGDLSKEDEIKKKALEI-------RCKDEPNITESTDVLL------ 468
            .|..|:.|..::::  .....|||::.:.:|...|:       ..::|..:.|..|..|      
Human   417 MEDEGRQRTTKYISCVFAEESDLSRQYQREKARSELLTTVSLASMQEESLLPEGEDTFLSESDSE 481

  Fly   469 --------------KDL-------PEI-------------VTNARPIAFK--------------- 484
                          ||.       |:.             |.|..|:..:               
Human   482 EERSSSKRRGRGSQKDTRASANLRPKTQPHHSTPTKGGWKVVNLHPLKKQPPSFPGAAEERACQS 546

  Fly   485 ----------------------------------IKKTRAAN---------------------QT 494
                                              |::.|..|                     :|
Human   547 LASRDSLLDTSSVSEPNVSFVSHCADSNSGDIAVIEEVRMENPKESSSSLKTGRHSSGQDKPHET 611

  Fly   495 QRQINRQKMIVRQIDQNCLV-SLPRVLRSVQETERQAGFKDSLCRRSLMRLLRPMVEENIINVFE 558
            .|.:.|:.:|:..:....|: ||..:.:.:.:.|:|.|.....|::|::||:|.:.||.::.::.
Human   612 YRLLKRRNLIIEAVTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIVRLVRNLSEEGLLRLYR 676

  Fly   559 ITLHYNQRVRVYRFATHPKIGLDHAVMKREIVKLK---SNFHLITEERMKRPSQMAPKERKEVLA 620
            .|:..:...:......||.:..:..:::..|.:::   ||..  |..|:|......|:...|..:
Human   677 TTVIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSS--TANRVKTSQPPVPQGEAEEDS 739

  Fly   621 RRKLAPERS-----NAVFKTQA---------------------------------PKLLLARTLH 647
            :.|..|..|     :|..::::                                 ||:...|.:|
Human   740 QGKEGPSGSGDSQLSASSRSESGRMKKSDNKMGITPLRNYHPIVVPGLGRSLGFLPKMPRLRVVH 804

  Fly   648 EFLYYL---HHELSPEQKPLPMSAELVQQWQKSEPALQPRQFFDEWQAD--------------ET 695
            .||:||   |...:..:||..:|.....:.:.....::|......|:|.              |.
Human   805 MFLWYLIYGHPASNTVEKPSFISERRTIKQESGRAGVRPSSSGSAWEACSEAPSKGSQDGVTWEA 869

  Fly   696 KVQ-----PYTEDIGWRTFIPPLPRYVDKPSGWLYFMDAMDRMPLSLFMRICRIEREANDDLRLQ 755
            :|:     .|.:|..|..:|||:|.:.|...||....|.:..:|||:|::|.::..:. |:|...
Human   870 EVELATETVYVDDASWMRYIPPIPVHRDFGFGWALVSDILLCLPLSIFIQIVQVSYKV-DNLEEF 933

  Fly   756 LQHPIRQHYLLSQLKLETIVPR-LKLQQIY--------VGTLRLLNNMGLIQVSEQKLGRDSLHR 811
            |..|:::|.|:      ..:|| ::.|.:|        |..|:.|..|||:|....:..:|....
Human   934 LNDPLKKHTLI------RFLPRPIRQQLLYKRRYIFSVVENLQRLCYMGLLQFGPTEKFQDKDQV 992

  Fly   812 WVFLNQRTSLLDTTSSTEHNYMQVSADRSYTKLNFEFSSVEQLGNYWAKLQHICIYTKLG----- 871
            ::||.:...::|||....| |....:.|.:.:..:..:|::.:.|||..||.:|:.|.||     
Human   993 FIFLKKNAVIVDTTICDPH-YNLARSSRPFERRLYVLNSMQDVENYWFDLQCVCLNTPLGVVRCP 1056

  Fly   872 -YRKSLST----------QRILPARL-------KVLVFQPTVEFDQAVELDNGTVPGDHLGAAGL 918
             .||:.||          |:...:.:       |..:.:.|....:.|  |.|.:|||.||||||
Human  1057 RVRKNSSTDQGSDEEGSLQKEQESAMDKHNLERKCAMLEYTTGSREVV--DEGLIPGDGLGAAGL 1119

  Fly   919 SSHLFAHQFRHWSW-------VQRQNGGKSNAAREKAKRTVRKRAVITRLKIGPRLAV----RKA 972
            .|..:.|..|:|.|       .:::|....|....:.:..:.||.:....:...||.:    |..
Human  1120 DSSFYGHLKRNWIWTSYIINQAKKENTAAENGLTVRLQTFLSKRPMPLSARGNSRLNIWGEARVG 1184

  Fly   973 RELSTG---------------------------KTLKKSSGPR--------------------DD 990
            .||..|                           |.|||..|.:                    |:
Human  1185 SELCAGWEEQFEVDREPSLDRNRRVRGGKSQKRKRLKKDPGKKIKRKKKGEFPGEKSKRLRYHDE 1249

  Fly   991 IDRDALRNMRTLRVKWAPEEDRLLKMGR----AVYMFIDAPTMTLALCDLAVVCRDLIR-RWLGI 1050
            .|:.||:.|..|||.|:.:||.||.:.|    .:...:..|.:|..      |.||::. .:...
Human  1250 ADQSALQRMTRLRVTWSMQEDGLLVLCRIASNVLNTKVKGPFVTWQ------VVRDILHATFEES 1308

  Fly  1051 CNKTTQACVRRVQFMVKMKRDIPDVPSWIYAMQTQPQFNTVYNERFLSQLKRDYPNKTDFQN--- 1112
            .:||:.:..||.:::||                 .||....| :..|:::.:|.....||.|   
Human  1309 LDKTSHSVGRRARYIVK-----------------NPQAYLNY-KVCLAEVYQDKALVGDFMNRRG 1355

  Fly  1113 ------ALMTHFALMMAKLQRMIAKSQGSVSRQFLLPDTLEAFGSQLRECRSAHEEQQLLFQDPA 1171
                  .....|...:.||:...:.:..:.:.:  :||||:...::.|......|:.|...:|..
Human  1356 DYDDPKVCANEFKEFVEKLKEKFSSALRNSNLE--IPDTLQELFARYRVLAIGDEKDQTRKEDEL 1418

  Fly  1172 -SETDLQVAVAHGVLHSNICCAKD--KTLLNLQTFEIYKHFSEEVLNSAFNKARADSLLVAVKRR 1233
             |..|:...|...::.|.:..:..  |:..:.|||.:|:.:.:.||..||.:.:..||   |.||
Human  1419 NSVDDIHFLVLQNLIQSTLALSDSQMKSYQSFQTFRLYREYKDHVLVKAFMECQKRSL---VNRR 1480

  Fly  1234 NIQSAASRQISGP-----------GHLLSSKYKYRL--------IYTKLTHFLYDCFFA---LDQ 1276
            .:....     ||           .:.||..| ||:        |.|:...|| |...|   |||
Human  1481 RVNHTL-----GPKKNRALPFVPMSYQLSQTY-YRIFTWRFPSTICTESFQFL-DRMRAAGKLDQ 1538

  Fly  1277 KLR---ADQEQ----------QLSSPHFGQLLVMGEWLSENRLSLSLQLPTNILTVDTTTVGRQ- 1327
            ..|   .||:.          .|..|. |..:.:....|...:|:.:::|..|:.||::.|..: 
Human  1539 PDRFSFKDQDNNEPTNDMVAFSLDGPG-GNCVAVLTLFSLGLISVDVRIPEQIIVVDSSMVENEV 1602

  Fly  1328 -SGCNSDRILDHYSCIFDNAPQTEYSKRLEGECSGRQAS-------RVLFHPANLSFR--LPTSA 1382
             .....|..|:......|:..:....||...|....|||       |..:.|..:|.|  .|..:
Human  1603 IKSLGKDGSLEDDEDEEDDLDEGVGGKRRSMEVKPAQASHTNYLLMRGYYSPGIVSTRNLNPNDS 1667

  Fly  1383 YNQLS---KLQLRAMHFFCALDALGEAITISQSRLEQFDCPFTNCIMRSGNYLNAVERIAHEQRP 1444
            ....|   |.|||.              |...:||.....|.....|.:....:...::.:.|. 
Human  1668 IVVNSCQMKFQLRC--------------TPVPARLRPAAAPLEELTMGTSCLPDTFTKLINPQE- 1717

  Fly  1445 ILRQLVADALPSQQFVLESHPAG-TPLTVTNANLLPFAQQLEA------FWREKQQ------AME 1496
                   :....::|||:...:| :|..:|.|     .:.|||      |..:|::      |:|
Human  1718 -------NTCSLEEFVLQLELSGYSPEDLTAA-----LEILEAIIATGCFGIDKEELRRRFSALE 1770

  Fly  1497 LKDLGKTLAERT----------QHKLTDWRSICAELLDDEPHAW------------ETERVQEYE 1539
            ....|:|   ||          ||::.:.....|.|: ....||            |...:|..:
Human  1771 KAGGGRT---RTFADCIQALLEQHQVLEVGGNTARLV-AMGSAWPWLLHSVRLKDREDADIQRED 1831

  Fly  1540 PALNKEERARAQDVFVVHLPTIGIKVVEQPEGKQTIDSLRTSVLDKVLKTTYWQYTENSFESLRP 1604
            |.....|.:.::|              ..|||:..                             |
Human  1832 PQARPLEGSSSED--------------SPPEGQAP-----------------------------P 1853

  Fly  1605 KLQESGYDDRAIRHMEDILYHIEKHTLGVKGLELRKIFPLGDFLLETLHLLADHNLIKRVGIVSV 1669
            .....|...||....|:          |....|..::.|      .....|.|.||...:|..: 
Human  1854 SHSPRGTKRRASWASEN----------GETDAEGTQMTP------AKRPALQDSNLAPSLGPGA- 1901

  Fly  1670 MYVHKNHIRNWVVHTFHIKRLEREKVQPMVAAAPGTLQ--AVVGHKRKLEAQETSSSVPEKRVKL 1732
                                  .:..:....:.|..|:  |..|     .|||....|.|.....
Human  1902 ----------------------EDGAEAQAPSPPPALEDTAAAG-----AAQEDQEGVGEFSSPG 1939

  Fly  1733 MEQLSTESESDEPGGSASKRPKRITRKEPSLEVANATLEATRDAIAMRPQPWIRVNASLNRRVLD 1797
            .||||.:::..|    .|:.|:..|....:..::.|..|...:::....:||..|:..||..|..
Human  1940 QEQLSGQAQPPE----GSEDPRGFTESFGAANISQAARERDCESVCFIGRPWRVVDGHLNLPVCK 2000

  Fly  1798 RWLGAVLSECIARVGCTVHSLFLRFLH-LVPVDVMFLLELLHDLGCIQ---LMEMRP-------- 1850
            ..:.|:|...:.|.|....||...:.. |.||.|:.||:.|..||||:   |.:.||        
Human  2001 GMMEAMLYHIMTRPGIPESSLLRHYQGVLQPVAVLELLQGLESLGCIRKRWLRKPRPVSLFSTPV 2065

  Fly  1851 -HKVHVESLLDDEHEDGDEQPVTELYDP 1877
             .:|.|.|.|       ||.|:. .|:|
Human  2066 VEEVEVPSSL-------DESPMA-FYEP 2085

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG7099NP_609648.1 B-block_TFIIIC 173..249 CDD:252431 29/86 (34%)
GTF3C1NP_001511.2 B-block_TFIIIC 174..250 CDD:252431 29/86 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..521 6/53 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 586..609 1/22 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..775 9/58 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 836..857 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1059..1082 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1202..1241 5/38 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1608..1631 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1823..1961 37/228 (16%)
HpaP 1881..>1975 CDD:304665 24/131 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159804
Domainoid 1 1.000 86 1.000 Domainoid score I8112
eggNOG 1 0.900 - - E1_KOG4560
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 288 1.000 Inparanoid score I2831
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D143012at2759
OrthoFinder 1 1.000 - - FOG0004836
OrthoInspector 1 1.000 - - oto88701
orthoMCL 1 0.900 - - OOG6_106119
Panther 1 1.100 - - LDO PTHR15180
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4004
SonicParanoid 1 1.000 - - X5964
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.790

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