DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7099 and Gtf3c1

DIOPT Version :9

Sequence 1:	NP_609648.1	Gene:	CG7099 / 34753	FlyBaseID:	FBgn0032517	Length:	1906	Species:	Drosophila melanogaster
Sequence 2:	NP_997122.1	Gene:	Gtf3c1 / 233863	MGIID:	107887	Length:	2101	Species:	Mus musculus

Alignment Length:	2301	Identity:	503/2301 - (21%)
Similarity:	816/2301 - (35%)	Gaps:	687/2301 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 INAIYDEVALEGLEGVTLPYLWDLLARRLEFFPSPLPDRIREQTWTLLLRTPPHKIEFFELPAER 74
            :.::.||||||||:|:.||.||..|..|...||.||....:|..|..|...|  .|.|:|.|.||
Mouse     4 LESLLDEVALEGLDGLCLPALWSRLESRSPAFPLPLEPYTQEFLWRALATHP--GISFYEEPRER 66

  Fly    75 PLMPYYDRLNDIDEQLGL------PVVPEQCPYMLFPAAYVQEG--DIKGNCNDFKTRKLIPSSD 131
            |.:...||..:||.:.|:      ||..|.    ::|...:.|.  .|:|:|..||.||.|.||
Mouse    67 PDLQLQDRYEEIDLETGILESRRDPVTLED----VYPIHMILENKDGIQGSCRYFKERKDITSS- 126

  Fly   132 LHS------LNAAQATEQWAGRLVVVASQELRETALTPESLLMPKNLPLP--NYIFLEAIGRSRY 188
            :.|      ....:|..:|..:|::||||::|..||.  .|....:|.||  :|..||.:||||:
Mouse   127 IRSKCLQPRCTMVEAFSRWGKKLIIVASQDMRYRALI--GLEGDPDLKLPDFSYCILERLGRSRW 189

  Fly   189 SG------HTTAGPWSLINYSKDTGILFY-----IKNKLINLQLIIAQNYNEINKGRILVSSLLM 242
            .|      ||||       :..|.|.|.|     .||.||.:|..:.:    :..|....|.||:
Mouse   190 QGELQRDLHTTA-------FKVDAGKLHYHRKILNKNGLITMQSHVIR----LPTGAQQHSILLL 243

  Fly   243 LPRFYRIYKNHSQENLEKLYLGIMRTPSRQVPVTEITDLLGRPTNFKTKKLLVTHSFRKFFE--- 304
            |.||:...::.....:|||.: ::.|.|.|:      :.||:   .:.:..|...:|::.::
Mouse   244 LNRFHVDRRSKYDILMEKLSM-MLSTRSNQI------ETLGK---LREELGLCERTFKRLYQYML 298

  Fly   305 ----TKQVERP---VAPLTKSGKQSKATTRKVTVIQLRNPDMQLKDLYK--NDDSEDNQVSEFLD 360
                .|.|..|   :.|.....|..|.|...|..::|      ||:..:  .||.:|:...|.:.
Mouse   299 NAGLAKVVSLPLQEIHPECGPCKTKKGTDVMVRCLKL------LKEFKRKMEDDHDDDDDEEVIS 357

  Fly   361 LGHCFLDMPPEEEVF---------RAVARFGKRGLNSNELCHYTGINATYMRHFVKRVKKHGLVK 416
            .|     :||.:.||         ..:.|.|.:|::..|:.....:.....|...:.:::..:||
Mouse   358 KG-----VPPVDIVFERDMLTQTYELIERRGTKGISQAEIRVAMNVGKLEARMLCRLLQRFKVVK 417

  Fly   417 EYSEQVGKSRQFRFVA--VGHLGDLSKEDEIKKKALEI-------RCKDEPNITESTDVLLKDLP 472
            .:.|..|:.|..::::  .....|||::...:|...|:       ..:||..:.|..:..|.|..
Mouse   418 GFMEDEGRQRTTKYISCVFAEESDLSRQYAREKARGELLTTVSLASVQDESLMPEGEEAFLSDSE 482

  Fly   473 E------------------------------------------IVTNARPIAFKIKKTRAA---- 491
            .                                          .|.|..|    :||.:||
Mouse   483 SEEESSCSGGKRRGRGSRGHARASGDAGSGSRPHHSTPAKGGWKVLNLHP----LKKPKAAAEER 543

  Fly   492 ----------------------------------------------------------------- 491

Mouse   544 SRRSSACRDGLDTSSSSELNAPFDPHSMDSHSGDIAVIEEVRLDNPKEGGGSQKGGRHGSSQDKP 608

  Fly   492 NQTQRQINRQKMIVRQIDQNCLV-SLPRVLRSVQETERQAGFKDSLCRRSLMRLLRPMVEENIIN 555
            ::|.|.:.|:.:|:..:....|: ||..:.:.:.:.|:|.|.....|::|::||:|.:.||.::.
Mouse   609 HKTYRLLKRRNLIIEAVTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIIRLVRNLSEEGLLR 673

  Fly   556 VFEITLHYNQRVRVYRFATHPKIGLDHAVMKREIVKLK---SNFHLITEERMKRPSQMAPKERKE 617
            ::..|:..:...:......||.:..:..:::..|.:::   ||..  |..|:|.|...||:|..|
Mouse   674 LYRTTVIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSS--TANRVKVPPAPAPQEEAE 736

  Fly   618 VLARRKLAPER-------------SNAVFKTQ-------------------------APKLLLAR 644
            ...:....|.|             |..|.||.                         .||:...:
Mouse   737 EENQEPEVPSRSANSDPNTSSKPESTRVKKTDEKMGITPLKNYKPVIVPGLGRSIGFLPKMPRLK 801

  Fly   645 TLHEFLYYL---HHELSPEQKPLPMSAELVQQWQKSEPALQPRQFFDEWQADETKVQP------- 699
            .:|.||:||   |......::|...|.....:.:.|.|..||.. .|:|...|.|...
Mouse   802 AMHLFLWYLVYGHPAGHTGEQPALHSERKTGKQESSRPGAQPSS-GDDWDTSEAKNNTESSSWES 865

  Fly   700 ---------YTEDIGWRTFIPPLPRYVDKPSGWLYFMDAMDRMPLSLFMRICRIEREANDDLRLQ 755
                     |.::|.|..::||:|.:.|...||....|.:..:|||:|:::.::..:. |:|...
Mouse   866 EMELSTEIVYVDEISWMRYVPPIPIHRDFGFGWALVSDILLCLPLSIFVQLVQVSYKV-DNLEDF 929

  Fly   756 LQHPIRQHYLLSQLKLETIVPR-LKLQQIY--------VGTLRLLNNMGLIQVSEQKLGRDSLHR 811
            |..|:::|.|:      ..:|| ::.|.:|        |..|:.|..|||:|....:..:|....
Mouse   930 LNDPLKKHTLI------RFLPRHIRQQLLYKRRYIFSVVENLQRLCYMGLLQFGPTEKFQDKDQV 988

  Fly   812 WVFLNQRTSLLDTTSSTEHNYMQVSADRSYTKLNFEFSSVEQLGNYWAKLQHICIYTKLGYRKSL 876
            :|||.:...::|||....| |....:.|.:.:..:...|::.:..||..||.||:.|.||..:..
Mouse   989 FVFLKKNAVIVDTTICDPH-YNLAHSSRPFERRLYVLDSMQDVECYWFDLQCICLNTPLGVVRCP 1052

  Fly   877 STQRILP----------------------ARLKVLVFQPTVEFDQAVELDNGTVPGDHLGAAGLS 919
            ..|:|.|                      ...|..:.:.|....:.|  |.|.||||.||||||.
Mouse  1053 CAQKICPDPGSDPEGSLRKEQESAMDKHNLERKCAMLEYTTGSREVV--DEGLVPGDGLGAAGLD 1115

  Fly   920 SHLFAHQFRHWSWVQ------RQNGGKSNAAREKAKRTVRKRAV--------------------- 957
            |..:||..|:|.|..      |:|....|....:.:..:.||.:
Mouse  1116 SSFYAHLKRNWVWTSYIINKARKNNTSENGLTGRLQTFLSKRPMPLGSGGSGRLPLWSEGRADAE 1180

  Fly   958 ------------------------------ITRLKIGPRLAVRKARELSTG---KTLKKSSGPRD 989
                                          ..|||..|   :||.:....|   :...|....:|
Mouse  1181 LCADKEEQFELDREPTPGRNRKVRGGKSQKRKRLKKEP---IRKTKRRRRGEHPEAKSKKLRYQD 1242

  Fly   990 DIDRDALRNMRTLRVKWAPEEDRLLKMGR----AVYMFIDAPTMTLALCDLAVVCRDLIR-RWLG 1049
            :.|::|||.|..|||.|:.:||.||.:.|    .:...:..|.:|..      |.||::. .:..
Mouse  1243 EADQNALRMMTRLRVSWSMQEDGLLMLCRIASNVLNTKVKGPFVTWQ------VVRDILHATFEE 1301

  Fly  1050 ICNKTTQACVRRVQFMVKMKRDIPDVPSWIYAMQTQPQFNTVYNER-----FLSQLKRDYPNKTD 1109
            ..:||:.:..||.:::||..:..         |..:.....||.::     |:|: |.:|.:
Mouse  1302 SLDKTSHSVGRRARYIVKNPQAF---------MNYKVCLAEVYQDKALVGDFMSR-KGNYED--- 1353

  Fly  1110 FQNALMTHFALMMAKLQRMIAKSQGSVSRQFLLPDTLEAFGSQLRECRSAHEEQQLLFQDPA-SE 1173
             .......|...:.||:...  |.|..:....:|:||:...::.|......|:.::..:|.. |.
Mouse  1354 -PKVCAKEFKEFVEKLKEKF--SSGLRNPNLEIPNTLQELFAKYRVLAIGDEKDRVRKEDELNSV 1415

  Fly  1174 TDLQVAVAHGVLHSNICC--AKDKTLLNLQTFEIYKHFSEEVLNSAFNKARADSLLVAVKRRNIQ 1236
            .|:...|...::.|.:..  ::..:..:.|.|.:|:.|.|.||..||.:.:..||   |.||.:.
Mouse  1416 EDIHFLVLQNLIQSTLSLSNSQSNSCQSFQIFRLYREFREPVLVRAFMECQKRSL---VNRRRVS 1477

  Fly  1237 SAASRQISGP-----------GHLLSSKYKYRLIYTKLTHFLYDCFFALDQKLRA----DQEQ-- 1284
            .:     .||           .:.||..| |:|...:....:....|....:||.    ||..
Mouse  1478 HS-----QGPKKNRAVPFVPMSYQLSQSY-YKLFTWRFPTTICTESFQFYDRLRTNGMLDQPDHF 1536

  Fly  1285 -----------------QLSSPHFGQLLVMGEWLSENRLSLSLQLPTNILTVDTTTV-------- 1324
                             .|.||. |..:......|...||:.:::|..|:.||::.|
Mouse  1537 SFKDLDSSDPSNDLVAFSLDSPG-GHCVTALALFSLGLLSVDVRIPEQIVVVDSSMVESEVMKSL 1600

  Fly  1325 GRQSGCNSD---RILDHYS-----CIFDNAPQTEYSKRL--------EGECSGRQAS---RVLFH 1370
            |:..|.:.|   ..||..|     .:...|.|..::|.|        .|..|.|..:   .::.:
Mouse  1601 GKDGGLDDDEEEEDLDEGSGTKRQGVEVKAHQASHTKYLLMRGYYTVPGMVSTRNLNPNDSIVVN 1665

  Fly  1371 PANLSFRL-PTSAYNQLSKLQLRAM---HFFCALDALGEAITISQSRLEQFDCP--FTNCIMRSG 1429
            ...:.||| .|.|..||......|.   .....|..|..:.|.......:..||  |.:.:.:||
Mouse  1666 SCQVKFRLRNTPASTQLGPTGFTATPLEELQAGLSCLPASFTSLVDPQLRTHCPEEFAHQMAQSG 1730

  Fly  1430 ------------------------------NYLNAVERIAHEQRPILRQLVADALPSQQFVLESH 1464
                                          ...:|:|:||..:.......:.|.|..:| |:|.
Mouse  1731 YSPEDVAASLEILQAVAAADCFGIDKEKLSRQFSALEKIADRRTRTFLDYIQDLLEQEQ-VMEV- 1793

  Fly  1465 PAGTPLTVTNANLLPFAQQLEAFWREKQQAMELKDL---GKTLAERTQHKLTDWRSICAELLDDE 1526
            ...|...||.|:..|:.          ..:|.|:|:   .|...:.:|.:|.:..||       |
Mouse  1794 GGNTVRLVTMASAQPWL----------LHSMRLRDMEVDTKASGDDSQSRLPEGPSI-------E 1841

  Fly  1527 PHAWETERVQEYEPALNKEERARAQDVFVVHLP-TIGIKVVEQPEGKQTIDSLRTSVLDKVLKTT 1590
            .|..|...|   .|..:...:.|.      |.| |...:....|..|.|:..:|.:.
Mouse  1842 DHTSEGAAV---PPVSSHSTKKRP------HCPETDAEEATRLPAKKPTLQDVRVAA-------- 1889

  Fly  1591 YWQYTENSFESLRPKLQESGYDDRAIRHMEDILYHIEKHTLGVKGLELRKIFPLGDFLLETLHLL 1655
                      |.||..:|
Mouse  1890 ----------SPRPGAEE----------------------------------------------- 1897

  Fly  1656 ADHNLIKRVGIVSVMYVHKNHIRNWVVHTFHIKRLEREKVQPMVAAAPGTLQAVVGHKRKLEAQE 1720
                                               :.|...|...|||....|  |..|    ||
Mouse  1898 -----------------------------------QAEAQAPAQLAAPEDADA--GGPR----QE 1921

  Fly  1721 TSSSVPEKRVKLMEQLSTESESDEPGGSASKRPKRITRKEPSLEVANATLEATRDAIAMRPQPWI 1785
            ...:|   .|..:|||..|.:..|    .|:.|:.:|..    .:|.|..|:..:.:....:||.
Mouse  1922 NQENV---GVSGLEQLGCEFQLPE----GSEDPRGLTES----NMAQAAWESGCERVCFVGRPWR 1975

  Fly  1786 RVNASLNRRVLDRWLGAVLSECIARVGCTVHSLFLRFLH--LVPVDVMFLLELLHDLGCIQLMEM 1848
            .|:..||..|....|.|||...::|.| ...|..|::..  |.||.|:.||..|..|||||...:
Mouse  1976 GVDGHLNMPVCKGMLEAVLYHIMSRPG-VPESCLLQYYQGVLQPVAVLELLRGLESLGCIQKRTL 2039

  Fly  1849 R-PHKVHVESLLDDEHEDGDEQPVTE 1873
            | |..|.:.|           :||.|
Mouse  2040 RKPASVSLFS-----------RPVVE 2054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7099	NP_609648.1	B-block_TFIIIC	173..249	CDD:252431	30/88 (34%)
Gtf3c1	NP_997122.1	B-block_TFIIIC	174..250	CDD:252431	29/86 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..574		9/104 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	588..609		0/20 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..772		14/55 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	820..864		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1186..1239		8/55 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1598..1627		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1822..1923		32/222 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850174
Domainoid	1	1.000	211	1.000	Domainoid score	I2805
eggNOG	1	0.900	-	-		E1_KOG4560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	336	1.000	Inparanoid score	I2383
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004836
OrthoInspector	1	1.000	-	-		oto92269
orthoMCL	1	0.900	-	-		OOG6_106119
Panther	1	1.100	-	-	LDO	PTHR15180
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4004
SonicParanoid	1	1.000	-	-		X5964
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.780