DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7099 and Gtf3c1

DIOPT Version :9

Sequence 1:	NP_609648.1	Gene:	CG7099 / 34753	FlyBaseID:	FBgn0032517	Length:	1906	Species:	Drosophila melanogaster
Sequence 2:	NP_598225.2	Gene:	Gtf3c1 / 171063	RGDID:	621048	Length:	2102	Species:	Rattus norvegicus

Alignment Length:	2278	Identity:	505/2278 - (22%)
Similarity:	832/2278 - (36%)	Gaps:	640/2278 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 INAIYDEVALEGLEGVTLPYLWDLLARRLEFFPSPLPDRIREQTWTLLLRTPPHKIEFFELPAER 74
            :.::.||||||||:|:.||.||..|..|...||.||....:|..|..|:..|  .|.|:|.|.||
  Rat     4 LESLLDEVALEGLDGLCLPALWSRLESRSPAFPLPLEPYTQEFLWRALVTHP--GISFYEEPRER 66

  Fly    75 PLMPYYDRLNDIDEQLGL------PVVPEQCPYMLFPAAYVQEG--DIKGNCNDFKTRKLIPSSD 131
            |.:...||..:||.:.|:      ||..|.    ::|...:.|.  .|:|:|..||.||.|.||
  Rat    67 PDLQLQDRYEEIDLETGILESRRDPVTLED----VYPIHMILENKDGIQGSCRYFKERKDITSS- 126

  Fly   132 LHS------LNAAQATEQWAGRLVVVASQELRETALTPESLLMPKNLPLP--NYIFLEAIGRSRY 188
            :.|      ....:|..:|..:|::||||::|..||.  .|....:|.||  :|..||.:||||:
  Rat   127 IRSKCLQPRCTMVEAFSRWGKKLIIVASQDMRYRALI--GLEGDPDLKLPDFSYCILERLGRSRW 189

  Fly   189 SG------HTTAGPWSLINYSKDTGILFY-----IKNKLINLQLIIAQNYNEINKGRILVSSLLM 242
            .|      ||||       :..|.|.|.|     .||.||.:|..:.:    :..|....|.||:
  Rat   190 QGELQRDLHTTA-------FKVDAGKLHYHRKILNKNGLITMQSHVIR----LPTGAQQHSILLL 243

  Fly   243 LPRFYRIYKNHSQENLEKLYLGIMRTPSRQVPVTEITDLLGRPTNFKTKKLLVTHSFRKFFE--- 304
            |.||:...::.....:|||.: ::.|.|.|:      :.||:   .:.:..|...:|::.::
  Rat   244 LNRFHVDRRSKYDILMEKLSM-MLSTRSNQI------ETLGK---LREELGLCERTFKRLYQYML 298

  Fly   305 ----TKQVERP---VAPLTKSGKQSKATTRKVTVIQLRNPDMQLKDLYK--NDDSEDNQVSEFLD 360
                .|.|..|   :.|.....|..|.|...|..::|      ||:..:  .||.:|:...|.:.
  Rat   299 NAGLAKVVSLPLQEIHPECGPCKTKKGTDVMVRCLKL------LKEFRRKMEDDHDDDDDEEAIS 357

  Fly   361 LGHCFLDMPPEEEVF---------RAVARFGKRGLNSNELCHYTGINATYMRHFVKRVKKHGLVK 416
            ..     :||.:.||         ..:.|.|.:|::..|:.....:.....|...:.:::..:||
  Rat   358 KA-----VPPVDIVFERDMLTQTYELIERRGTKGISQAEIRVAMNVGKLEARMLCRLLQRFKVVK 417

  Fly   417 EYSEQVGKSRQFRFVA--VGHLGDLSKEDEIKKKALEI-------RCKDEPNITESTDVLLKD-- 470
            .:.|..|:.|..::::  .....|||::...:|...|:       ..:||..:.|..:..|.|
  Rat   418 GFMEDEGRQRTTKYISCVFAEESDLSRQYAREKARGELLTTVSLASVQDESLMPEGEEAFLSDSE 482

  Fly   471 ------------------------------LPEIVTNA-------------RPIAFKIKKTRAA- 491
                                          .|...|.|             :|.:..::::|.:
  Rat   483 SEEESSCSGKRRGRGSRGHSRASGDAGPGSRPHHSTPAKGGWKVLNLHPLKKPKSAAVERSRRSS 547

  Fly   492 ------------------------------------------------------------NQTQR 496
                                                                        ::|.|
  Rat   548 ACRDGLDTSSSSELNIPFDPHSMDSHSGDIAVIEEVRLDNPKEGGGSQKGGRHGSGQDKPHKTYR 612

  Fly   497 QINRQKMIVRQIDQNCLV-SLPRVLRSVQETERQAGFKDSLCRRSLMRLLRPMVEENIINVFEIT 560
            .:.|:.:|:..:....|: ||..:.:.:.:.|:|.|.....|::|::||:|.:.||.::.::..|
  Rat   613 LLKRRNLIIEAVTNLRLIESLFTIQKMIMDQEKQEGVSTKCCKKSIIRLVRNLSEEGLLRLYRTT 677

  Fly   561 LHYNQRVRVYRFATHPKIGLDHAVMKREIVKLK---SNFHLITEERMKRPSQMAPKERKEVLARR 622
            :..:...:......||.:..:..:::..|.:::   ||..  |..|:|.|...||:|..|...:.
  Rat   678 VIQDGIKKKVDLVVHPSMDQNDPLVRSAIEQVRFRISNSS--TANRVKVPPAPAPQEEAEEGNQE 740

  Fly   623 KLAPER-------------SNAVFKTQ-------------------------APKLLLARTLHEF 649
            ...|.|             |..|.||.                         .||:...|.:|.|
  Rat   741 PEVPSRSADSEANTSSKPESTRVKKTDEKMGITPLKNYKPVIVPGLGRSIGFLPKMPRLRVMHLF 805

  Fly   650 LYYL---HHELSPEQKPLPMSAELVQQWQKSEPALQPRQFFDEWQADETK--------------- 696
            |:||   |......::|...|.....:.:.|.|.:||.. .|:|.:.|.|
  Rat   806 LWYLVYGHPASHTGEQPTFHSERKTGKQEPSRPGVQPSS-GDDWDSSEAKNSTESSSWEAEMELS 869

  Fly   697 -VQPYTEDIGWRTFIPPLPRYVDKPSGWLYFMDAMDRMPLSLFMRICRIEREANDDLRLQLQHPI 760
             .:.|.::|.|..::||:|.:.|...||....|.:..:|||:|:::.::..:. |:|...|..|:
  Rat   870 TERVYVDEISWMRYVPPIPIHRDFGFGWALVSDILLCLPLSIFVQVVQVSYKV-DNLEDFLNDPL 933

  Fly   761 RQHYLLSQLKLETIVPR-LKLQQIY--------VGTLRLLNNMGLIQVSEQKLGRDSLHRWVFLN 816
            ::|.|:      ..:|| ::.|.:|        |..|:.|..|||:|....:..:|....:|||.
  Rat   934 KKHTLI------RFLPRHIRQQLLYKRRYIFSVVENLQRLCYMGLLQFGPTEKFQDKDQVFVFLK 992

  Fly   817 QRTSLLDTTSSTEHNYMQVSADRSYTKLNFEFSSVEQLGNYWAKLQHICIYTKLGYRKSLSTQRI 881
            :...::|||....| |....:.|.:.:..:...|::.:.:||..||.||:.|.||..:....|:|
  Rat   993 KNAVIVDTTICDPH-YNLAHSSRPFERRLYVLDSMQDVESYWFDLQCICLNTPLGVVRCPCAQKI 1056

  Fly   882 LP----------------------ARLKVLVFQPTVEFDQAVELDNGTVPGDHLGAAGLSSHLFA 924
            .|                      ...|..:.:.|....:.|  |.|.||||.||||||.|..:|
  Rat  1057 CPDPGSDPEGSLRKEQESAMDKHNLERKCAMLEYTTGSREVV--DEGLVPGDGLGAAGLDSSFYA 1119

  Fly   925 HQFRHWSWVQ-----------RQNG-----------------------------GKSNAA----- 944
            |..|:|.|..           .:||                             ||::|.
  Rat  1120 HLKRNWVWTSYIINKARKNNTSENGLTGRLQTFLSKRPMPLGSGGSGRLPLWSEGKADAELCADK 1184

  Fly   945 -------REKA---KRTVR--KRAVITRLKIGPRLAVRKARELSTG---KTLKKSSGPRDDIDRD 994
                   ||..   .|.||  |.....|||..|   :||.:....|   :...|....:|:.|::
  Rat  1185 EEHFELDREPTPGRNRKVRGGKSQKRKRLKKEP---IRKTKRRRRGEHPEAKSKKLRYQDEADQN 1246

  Fly   995 ALRNMRTLRVKWAPEEDRLLKMGR----AVYMFIDAPTMTLALCDLAVVCRDLIR-RWLGICNKT 1054
            |||.|..|||.|:.:||.||.:.|    .:...:..|.:|..      |.||::. .:....:||
  Rat  1247 ALRMMTRLRVSWSMQEDGLLMLCRIASNVLNTKVKGPFVTWQ------VVRDILHATFEESLDKT 1305

  Fly  1055 TQACVRRVQFMVKMKRDIPDVPSWIYAMQTQPQFNTVYNER-----FLSQLKRDYPNKTDFQNAL 1114
            :.:..||.:::||..:..         |..:.....||.::     |:|: |.:|.:    ....
  Rat  1306 SHSVGRRARYIVKNPQAF---------MNYKVCLAEVYQDKALVGDFMSR-KDNYED----PKVC 1356

  Fly  1115 MTHFALMMAKLQRMIAKSQGSVSRQFLLPDTLEAFGSQLRECRSAHEEQQLLFQDPA-SETDLQV 1178
            ...|...:.||:...  |.|..:....:||||:...::.|......|:.::..:|.. |..|:..
  Rat  1357 AKEFKEFVEKLKEKF--SSGLRNPNLEIPDTLQELFAKYRVLAIGDEKDRVRKEDELNSVEDIHF 1419

  Fly  1179 AVAHGVLHSNICC--AKDKTLLNLQTFEIYKHFSEEVLNSAFNKARADSLLVAVKRRNIQSAASR 1241
            .|...::.|.:..  ::..:..:.|.|.:|:.|.|.||..||.:.:..||   |.||.:..:
  Rat  1420 LVLQNLIQSTLSLSNSQSNSCQSFQIFRLYREFREPVLVRAFMECQKRSL---VNRRRVSHS--- 1478

  Fly  1242 QISGP-----------GHLLSSKYKYRLIYTKLTHFLYDCFFALDQKLRA----DQEQ------- 1284
              .||           .:.||..| |:|...:....:....|....:|||    ||..
  Rat  1479 --QGPKKNRAVPFVPMSYQLSQSY-YKLFTWRFPTTVCTESFQFYDRLRANGILDQPDHFSFKDM 1540

  Fly  1285 ------------QLSSPHFGQLLVMGEWLSENRLSLSLQLPTNILTVDTTTV--------GRQSG 1329
                        .|.||. |..:......|...||:.:::|..|:.||::.|        |:..|
  Rat  1541 DSNDPSSDLVAFSLDSPG-GHCVTALALFSLGLLSVDVRIPEQIVVVDSSMVESEVMKSLGKDGG 1604

  Fly  1330 CNSDRILDHYSCIFDNAPQTEYSKRLEGECSGRQASRVLFHPANLSFRLPTSAYNQLSKLQLRAM 1394
            .:.|          |.....:     ||..:.||:..|..|.|:.:..|....|
  Rat  1605 LDDD----------DEEEDLD-----EGSGTKRQSVEVKAHQASHTKYLLMRGY----------- 1643

  Fly  1395 HFFCALDALGEAITISQSRLEQFDCPFTNCIMRSGNYLNAVERIAHEQRPILRQLVADALPSQQF 1459
                                      :|...|.|...||..:.|......:            :|
  Rat  1644 --------------------------YTVPGMVSTRNLNPNDSIVVNSCQV------------KF 1670

  Fly  1460 VLESHPAGTPLTVTNANLLPFAQQLEAFWREKQQAMELKDLGKTLAERTQHKLTDWRSICAELLD 1524
            .|.:.||.|.|..|.....|. ::|:|              |.:....:...|.|     .:|..
  Rat  1671 RLRNTPAPTHLGPTGPTATPL-EELQA--------------GPSCLPASFTSLVD-----PQLHT 1715

  Fly  1525 DEPHAWETERVQE-YEP-----ALNKEERARAQDVFVVHLPTIGIKVVEQPEGKQTIDSLRTSVL 1583
            ..|..:..:..|. |.|     :|...:...|.|.|.|....:               |.:.|.|
  Rat  1716 RCPEEFAHQMAQSGYSPEDVAASLEILQAVAAADCFGVDREKL---------------SRQFSAL 1765

  Fly  1584 DKVL---KTTYWQYTENSFESLRPKLQESGYDDRAIRHMEDI---------LYHIEKHTLGVKGL 1636
            :|:.   ..|:..|.::..|  :.::.|.|.:...:..|...         |..:|..| ...|.
  Rat  1766 EKIADKRTRTFLDYIQDLLE--QQQVMEVGGNTVRLVAMASAQPWLLPSVRLKDVEIDT-KASGD 1827

  Fly  1637 ELRKIFPLGDFLLETLHLLADHNLIKRVGIVSVMYVHKNHIRNWVVHTFHIKRLEREKVQPMVAA 1701
            :.:...|.|.       .:.||.   ..| ..:..|..|..:.....:......:.|:...:.|.
  Rat  1828 DSQSRLPAGS-------SIEDHT---SEG-APIPPVSSNGTKKRPYCSIQSPETDAEEATRLPAK 1881

  Fly  1702 APGTLQAVV-------GHKRKLEA----------------QETSSSVPEKRVKLMEQLSTESESD 1743
            .| |||.|.       |.:.:.||                ||:..||   .|..:|||..|.:..
  Rat  1882 KP-TLQDVCVAASPRPGTEEQTEAQAQFAAPEDAGAEGPRQESQESV---GVSGLEQLGCEFQLP 1942

  Fly  1744 EPGGSASKRPKRITRKEPSLEVANATLEATRDAIAMRPQPWIRVNASLNRRVLDRWLGAVLSECI 1808
            |    .|:.|:.:|..    .:|....|:..:.:....:||..|:..||..|....:.|||...:
  Rat  1943 E----NSEDPRGLTES----NMAQVAWESGCERVCFVGRPWRGVDGRLNMPVCKGMMEAVLYHIM 1999

  Fly  1809 ARVGCTVHSLFLRFLH--LVPVDVMFLLELLHDLGCIQ-LMEMRPHKVHVESLLDDEHEDGDEQP 1870
            :|.| ...|..|::..  |.||.|:.||..|..||||| .|..:|..|.:.|           :|
  Rat  2000 SRPG-VPESCLLQYYQGVLQPVAVLELLRGLESLGCIQKRMLKKPASVSLFS-----------RP 2052

  Fly  1871 VTE 1873
            |.|
  Rat  2053 VVE 2055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7099	NP_609648.1	B-block_TFIIIC	173..249	CDD:252431	30/88 (34%)
Gtf3c1	NP_598225.2	B-block_TFIIIC	174..250	CDD:252431	29/86 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	473..568		7/94 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..609		0/21 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..771		14/55 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..863		10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1186..1238		14/54 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1597..1627		8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1823..1881		9/68 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1893..1928		7/37 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353867
Domainoid	1	1.000	214	1.000	Domainoid score	I2655
eggNOG	1	0.900	-	-		E1_KOG4560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	340	1.000	Inparanoid score	I2287
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143012at2759
OrthoFinder	1	1.000	-	-		FOG0004836
OrthoInspector	1	1.000	-	-		oto95832
orthoMCL	1	0.900	-	-		OOG6_106119
Panther	1	1.100	-	-	LDO	PTHR15180
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5964
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760