DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ing5 and TAF3

DIOPT Version :9

Sequence 1:NP_609647.1 Gene:Ing5 / 34752 FlyBaseID:FBgn0032516 Length:285 Species:Drosophila melanogaster
Sequence 2:NP_114129.1 Gene:TAF3 / 83860 HGNCID:17303 Length:929 Species:Homo sapiens


Alignment Length:417 Identity:83/417 - (19%)
Similarity:134/417 - (32%) Gaps:160/417 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 TELERNFKLMRKLDDRAQTAMKSIDSHAKDFMRKLGENGAMS--EDERRERQEDIKALFGK---- 77
            |:|..:.::.:||....:|.||..:.. :|..|:..:|...|  :|:.:|:::|.:.  |:    
Human   513 TKLPSSVEVKKKLKKELKTKMKKKEKQ-RDREREKDKNKDKSKEKDKVKEKEKDKET--GRETKY 574

  Fly    78 -----AKEYSDDKVQLAIQTYELVDKQIRRLDNDLARFEGEIQEKASSTRAKSEEVVAKKGRKKT 137
                 .||...|..:..|:.:|.||.:: :|.:.|.|.|.|..:.....|.|.::...|:.::|.
Human   575 PWKEFLKEEEADPYKFKIKEFEDVDPKV-KLKDGLVRKEKEKHKDKKKDREKGKKDKDKREKEKV 638

  Fly   138 KDSKTTGKKKKSAS--------------SDEETGR----------------GNNQSNANSSVNSS 172
            ||.....|.|..|.              |.....|                ...:..........
Human   639 KDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKEKKK 703

  Fly   173 SNAGQGSKKKKSKVNQEKETRKGGAQKKTVEVDDSEKE-------SCHTAATHPSDVMD------ 224
            ....:..||:|.|..:|||..|   :|:..|..:.|||       .....|..||.|:.      
Human   704 DKKEKKKKKEKEKEKKEKEREK---EKREREKREKEKEKHKHEKIKVEPVALAPSPVIPRLTLRV 765

  Fly   225 ------------MPVDPNEP--------------------------------------------- 232
                        :|....:|                                             
Human   766 GAGQDKIVISKVVPAPEAKPAPSQNRPKTPPPAPAPAPGPMLVSPAPVPLPLLAQAAAGPALLPS 830

  Fly   233 -----------------------TYCL-------------CHQVSYGE-MIGCDNPDCPIEWFHF 260
                                   ||.:             |::...|. |||||  ||. :|:|:
Human   831 PGPAASGASAKAPVRSVVTETVSTYVIRDEWGNQIWICPGCNKPDDGSPMIGCD--DCD-DWYHW 892

  Fly   261 ACVGLTTKP--KGKWFCPKCTQDRKKK 285
            .|||:.|.|  :.:||||||...:|.|
Human   893 PCVGIMTAPPEEMQWFCPKCANKKKDK 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ing5NP_609647.1 TNG2 1..278 CDD:227367 79/408 (19%)
ING 6..108 CDD:289749 23/99 (23%)
PHD_ING4_5 234..278 CDD:277061 21/59 (36%)
TAF3NP_114129.1 BTP 5..79 CDD:128846
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 131..152
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 176..197
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 221..358
PTZ00449 <229..388 CDD:185628
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 405..578 15/67 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 603..658 14/54 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 692..748 13/58 (22%)
PRK12323 <777..>847 CDD:237057 2/69 (3%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 778..807 2/28 (7%)
PHD_TAF3 867..912 CDD:276997 20/47 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5034
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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