Protein Alignment Ing5 and ING4

DIOPT Version :10

• Sequence 1: NP_609647.1
• Gene: Ing5 / 34752
• FlyBaseID: FBgn0032516
• Length: 285
• Species: Drosophila melanogaster
• Sequence 2: NP_001121054.1
• Gene: ING4 / 51147
• HGNCID: 19423
• Length: 249
• Species: Homo sapiens
• Alignment Length: 296
• Identity: 142/296 - (47%)
• Similarity: 181/296 - (61%)
• Gaps: 58/296 - (19%)

  Fly     1 MSSAIYLENYLDGLESLPTELERNFKLMRKLDDRAQTAMKSIDSHAKDFMRKLGENGAMSEDERR 65
            |::.:|||:|||.:|:||.||:|||:|||.||.|.:.....||..|.::|   ....::|.:|:.
Human     1 MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYM---SSARSLSSEEKL 62

  Fly    66 ERQEDIKALFGKAKEYSDDKVQLAIQTYELVDKQIRRLDNDLARFEGEIQEK--------ASSTR 122
            ...:.|:..:||.||:.|||||||:||||:|||.|||||.||||||.:::||        :||::
Human    63 ALLKQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSK 127

  Fly   123 AKSEEVVAKKGRKKTKDSKTTGKKKKSASSDEETGRGNNQSNANSSVNSSSNAGQGSKKKKSKVN 187
            .|      ||||.: |:.|....:.|..:||||..:
Human   128 GK------KKGRTQ-KEKKAARARSKGKNSDEEAPK----------------------------- 156

  Fly   188 QEKETRKGGAQKKTVEVDDSEK---ESCHTAATHPSDVMDMPVDPNEPTYCLCHQVSYGEMIGCD 249
                    .||||...|..|.:   .|....:.|||||:||||||||||||||||||||||||||
Human   157 --------TAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCD 213

  Fly   250 NPDCPIEWFHFACVGLTTKPKGKWFCPKCTQDRKKK 285
            ||||.|||||||||||||||:||||||:|:|:||||
Human   214 NPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ing5	NP_609647.1	ING_ING4_5	14..107	CDD:341092	44/92 (48%)
		PHD_ING4_5	234..278	CDD:277061	41/43 (95%)
ING4	NP_001121054.1	TNG2	7..245	CDD:227367	135/284 (48%)
		ING_ING4	11..104	CDD:341095	46/95 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	115..164		18/92 (20%)
		Bipartite nuclear localization signal	127..148		8/27 (30%)