DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ing5 and Ing4

DIOPT Version :9

Sequence 1:	NP_609647.1	Gene:	Ing5 / 34752	FlyBaseID:	FBgn0032516	Length:	285	Species:	Drosophila melanogaster
Sequence 2:	XP_006237411.1	Gene:	Ing4 / 297597	RGDID:	1309407	Length:	249	Species:	Rattus norvegicus

Alignment Length:	296	Identity:	141/296 - (47%)
Similarity:	180/296 - (60%)	Gaps:	58/296 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSSAIYLENYLDGLESLPTELERNFKLMRKLDDRAQTAMKSIDSHAKDFMRKLGENGAMSEDERR 65
            |::.:|||:|||.:|:||.||:|||:|||.||.|.:.....||..|.::|   ....::|.:|:.
  Rat     1 MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYM---SSARSLSSEEKL 62

  Fly    66 ERQEDIKALFGKAKEYSDDKVQLAIQTYELVDKQIRRLDNDLARFEGEIQEK--------ASSTR 122
            .....|:..:||.||:.|||||||:||||:|||.|||||.||||||.:::||        :||::
  Rat    63 ALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSK 127

  Fly   123 AKSEEVVAKKGRKKTKDSKTTGKKKKSASSDEETGRGNNQSNANSSVNSSSNAGQGSKKKKSKVN 187
            .|      :|||.: |:.|....:.|..:||||..:
  Rat   128 GK------RKGRTQ-KEKKAARARSKGKNSDEEAPK----------------------------- 156

  Fly   188 QEKETRKGGAQKKTVEVDDSEK---ESCHTAATHPSDVMDMPVDPNEPTYCLCHQVSYGEMIGCD 249
                    .||||...|..|.:   .|....:.|||||:||||||||||||||||||||||||||
  Rat   157 --------AAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCD 213

  Fly   250 NPDCPIEWFHFACVGLTTKPKGKWFCPKCTQDRKKK 285
            ||||.|||||||||||||||:||||||:|:|:||||
  Rat   214 NPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK 249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ing5	NP_609647.1	TNG2	1..278	CDD:227367	135/287 (47%)
		ING	6..108	CDD:289749	51/101 (50%)
		PHD_ING4_5	234..278	CDD:277061	41/43 (95%)
Ing4	XP_006237411.1	TNG2	7..245	CDD:227367	134/284 (47%)
Ing4	XP_006237411.1	ING_ING4	11..104	CDD:341095	46/95 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3783
eggNOG	1	0.900	-	-		E1_COG5034
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22952
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3031
OMA	1	1.010	-	-		QHG55959
OrthoDB	1	1.010	-	-		D1434088at2759
OrthoFinder	1	1.000	-	-		FOG0000296
OrthoInspector	1	1.000	-	-		otm45014
orthoMCL	1	0.900	-	-		OOG6_101415
Panther	1	1.100	-	-	LDO	PTHR10333
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X195
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840