DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DGAT2L6 and CG1946

DIOPT Version :9

Sequence 1:	NP_940914.1	Gene:	DGAT2L6 / 347516	HGNCID:	23250	Length:	337	Species:	Homo sapiens
Sequence 2:	NP_610319.2	Gene:	CG1946 / 35720	FlyBaseID:	FBgn0033216	Length:	349	Species:	Drosophila melanogaster

Alignment Length:	348	Identity:	128/348 - (36%)
Similarity:	190/348 - (54%)	Gaps:	27/348 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     6 RLNLQEGLQT----FFVLQW--IPVYIFLGAIPILLIPYFLLFSKFWPLAVLSLAWLTYDWNTHS 64
            |:.|:..|||    ||...:  :|:...| |:.|||. |..:|.:...|......:|.|..|...
  Fly     9 RVPLERRLQTLVTSFFTYTFFTLPISSCL-AVAILLY-YGEMFVRSLLLIYFVKIYLDYKRNYGI 71

Human    65 QGGRRSAWVRNWTLWKYFRNYFPVKLVKTHDLSPKHNYIIANHPHGILSFGVFINFATEATGIAR 129
            ..|  :.|:...:.|:| ||||||:||||.:|.|..|||:|:.|||||..|..||.:.:......
  Fly    72 MEG--NGWLFYRSNWRY-RNYFPVELVKTAELPPNRNYIVASFPHGILGTGTCINMSLDIDNWLS 133

Human   130 IFPSITPFVGTLERIFWIPIVREYVMSMGVCPVSSSALKYLLTQKG-----------SGNAVVIV 183
            ::|.:.|.:.||:..|..|.:|:.:...|:..||..:|.|||::..           :.|||.::
  Fly   134 LYPHVRPKIATLDHHFKTPFLRDILRWWGMVSVSKESLSYLLSKSNDPMHKDNRDGFTSNAVAVL 198

Human   184 VGGAAEALLCRPGASTLFLKQRKGFVKMALQTGAYLVPSYSFGENEVFNQETFPEGTWLRLFQKT 248
            ||||.||:...||...|.||.||||||||::||:.:|||.||||.::|:|...|..:.||    .
  Fly   199 VGGAKEAMDSHPGQYILTLKDRKGFVKMAVRTGSSIVPSLSFGEVDIFDQVANPPDSSLR----R 259

Human   249 FQDTFKKILGLNFCTFHGRGFTRGSWGFLPFNRPITTVVGEPLPIPRIKRPNQKTVDKYHALYIS 313
            ||:..||..|::.....|||....::|.||..|.|..|||.|:.:.|.:.|:.:.|||.|...|.
  Fly   260 FQNVVKKFTGISPLLPKGRGIFNYNYGILPHRRRIVQVVGSPIDVERCETPDPEYVDKIHGQVID 324

Human   314 ALRKLFDQHKVEYGLPETQELTI 336
            ||.::||::|.:| .|.::.:.:
  Fly   325 ALARMFDEYKEKY-TPNSKHIKL 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DGAT2L6	NP_940914.1	LPLAT	38..336	CDD:302626	115/308 (37%)
CG1946	NP_610319.2	LPLAT	80..349	CDD:302626	107/273 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146787
Domainoid	1	1.000	214	1.000	Domainoid score	I2726
eggNOG	1	0.900	-	-		E1_KOG0831
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3400
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53531
OrthoDB	1	1.010	-	-		D1347007at2759
OrthoFinder	1	1.000	-	-		FOG0000289
OrthoInspector	1	1.000	-	-		mtm8637
orthoMCL	1	0.900	-	-		OOG6_100399
Panther	1	1.100	-	-	O	PTHR12317
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X186
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.770