DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment loqs and ZFR2

DIOPT Version :9

Sequence 1:	NP_609646.1	Gene:	loqs / 34751	FlyBaseID:	FBgn0032515	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_011526133.1	Gene:	ZFR2 / 23217	HGNCID:	29189	Length:	940	Species:	Homo sapiens

Alignment Length:	464	Identity:	80/464 - (17%)
Similarity:	139/464 - (29%)	Gaps:	162/464 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QQLQNLH---------IQPQQASPNPVQTGFAPRRHYNNLVGLGNGNAVSGSPV------KGAPL 62
            |::..||         ::|..|:.:|......|.......|...:..|::..||      :|.|
Human   344 QKVFKLHAKLGKPIPTLEPALATESPPGAEAKPTSPTGPSVCASSRPALAKRPVASKALCEGPP- 407

  Fly    63 GQRHVKLKKEKISAQVA----QLSQPGQLQLSDVGDPALAGGSGLQGGVGLMGVILP-------S 116
                        ..|.|    |..:|.|.:|...|.|...|......|......:.|       |
Human   408 ------------EPQAAGCRPQWGKPAQPKLEGPGAPTQGGSKEAPAGCSDAQPVGPEYVEEVFS 460

  Fly   117 DE--ALKF---VSETDANGLAMKTPVSILQELLSRRGITPGYELVQIEGAIHEPTFRFRVSFKDK 176
            ||  .|:|   :.|...|.|..|.                    :.:.|..|...:|.:|   :.
Human   461 DEGRVLRFHCKLCECSFNDLNAKD--------------------LHVRGRRHRLQYRKKV---NP 502

  Fly   177 DTPFTAMGAGRSKK--EAKHAAARALIDKLI---------GAQLPESPSSSAGPSVTGLTVAGSG 230
            |.|.....:.|::|  |.:....|.|.::.:         ..:|.|.|.....|..
Human   503 DLPIATEPSSRARKVLEERMRKQRHLAEERLEQLRRWHAERRRLEEEPPQDVPPHA--------- 558

  Fly   231 GDGNANATGGGDASDKTVGNPIGWLQEMCMQRRWPP----------PSYETETEVGLPHERLFTI 285
                                |..|.|.:.|.|...|          |:...:..|...|..::..
Human   559 --------------------PPDWAQPLLMGRPESPASAPLQPGRRPASSDDRHVMCKHATIYPT 603

  Fly   286 ACSILNYREMGKGKSKKIAKRLAAH-RMWMRLQETPIDSGKISDSIC------GELEGEPRSSEN 343
            ...:|            ..:|..:| ...::|         :||::.      .|.||:.|||
Human   604 EQELL------------AVQRAVSHAERALKL---------VSDTLAEEDRGRREEEGDKRSS-- 645

  Fly   344 YYGELKDISVPTLTTQHSNKVSQFHKTLKNATGKKLLKLQKTCLKNNKIDYIKLLG-------EI 401
                   ::..|...:...:|....|.|. ..|.:.::|...|.:......::.:.       ::
Human   646 -------VAPQTRVLKGVMRVGILAKGLL-LRGDRNVRLALLCSEKPTHSLLRRIAQQLPRQLQM 702

  Fly   402 ATENQFEVT 410
            .||:::||:
Human   703 VTEDEYEVS 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
loqs	NP_609646.1	DSRM	136..204	CDD:214634	11/69 (16%)
		DSRM	250..316	CDD:238007	12/76 (16%)
		DSRM	394..460	CDD:214634	4/24 (17%)
ZFR2	XP_011526133.1	ZnF_U1	271..300	CDD:197732
		C2H2 Zn finger	273..295	CDD:275371
		ZnF_U1	318..350	CDD:197732	1/5 (20%)
		C2H2 Zn finger	321..343	CDD:275371
		ZnF_U1	467..498	CDD:197732	7/50 (14%)
		C2H2 Zn finger	470..492	CDD:275371	5/41 (12%)
		DZF	652..905	CDD:128842	10/61 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158136
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930