Protein Alignment CG9302 and PDIA4

DIOPT Version :10

• Sequence 1: NP_609645.2
• Gene: CG9302 / 34750
• FlyBaseID: FBgn0032514
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001358173.1
• Gene: PDIA4 / 9601
• HGNCID: 30167
• Length: 646
• Species: Homo sapiens
• Alignment Length: 606
• Identity: 135/606 - (22%)
• Similarity: 207/606 - (34%)
• Gaps: 246/606 - (40%)

  Fly   133 DLPWEEDPAGKDVLHFSDAASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKASTELKTKGGY 197
            ||..:|:   ..||..:| |:|...: .|...:|:.||.||||.||:..|||.|.:..||.|...
Human    55 DLEVKEE---NGVLVLND-ANFDNFV-ADKDTVLLEFYAPWCGHCKQFAPEYEKIANILKDKDPP 114

  Fly   198 ILAAMNVERQENAPIRKMFNITGFPTLIYFENGKLRFTYEGENNKEALVSFMLNPNAKPTPKPKE 262
            |..| .::....:.:...|:::|:||:...:.|: ...|||...:|.:|:        ...:..:
Human   115 IPVA-KIDATSASVLASRFDVSGYPTIKILKKGQ-AVDYEGSRTQEEIVA--------KVREVSQ 169

  Fly   263 PEWSADTNSEIVHLTSQGFEPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALEMKQKKIPGLLA 327
            |:|:......:| ||.:.|:..:.|....||.||||||||||::.|||||||.|:.::..|..||
Human   170 PDWTPPPEVTLV-LTKENFDEVVNDADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLA 233

  Fly   328 ALDATKEPSIAEKYKVKGYPTVKFFSN-------------------------------------- 354
            .:|||.|..:|:::.|.||||:|.|..
Human   234 KVDATAETDLAKRFDVSGYPTLKIFRKGRPYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQE 298

  Fly   355 -----------GVFKFEV------------NVRE--------ASKIVEFMRDPKEPPPPPPPEK- 387
                       ||||.|.            |:||        :::|.:|::..:.......|||
Human   299 FLKDGDDVIIIGVFKGESDPAYQQYQDAANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKF 363

  Fly   388 ----------------------------------------------------------------- 387
                                                                             
Human   364 QSKYEPRSHMMDVQQGSTQDSAIKDFVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDY 428

  Fly   388 -----SW-------------------EEEEDSKEV--------------LFLDD---------DN 405
                 .|                   :||:.:.||              ..||:         :.
Human   429 RAATQFWRSKVLEVAKDFPEYTFAIADEEDYAGEVKDLGLSESGEDVNAAILDESGKKFAMEPEE 493

  Fly   406 F-SSTLKR------------------------------------------KKHALVMFYAPWCGH 427
            | |.||:.                                          ||..|:.||||||||
Human   494 FDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPVKVVVGKTFDSIVMDPKKDVLIEFYAPWCGH 558

  Fly   428 CKHTKPEFTAAATALQDDPRIAFVAIDCTKLAALCAKYNVRGYPTILYFS---YLKTKLDYNGG- 488
            ||..:|.:.:.|...:....:....:|.|.......:|.|.|:||| ||:   ..|..:.:.||
Human   559 CKQLEPVYNSLAKKYKGQKGLVIAKMDATANDVPSDRYKVEGFPTI-YFAPSGDKKNPVKFEGGD 622

  Fly   489 RTSKDFIAYMNNPPTSADRTE 509
            |..:....::....|...||:
Human   623 RDLEHLSKFIEEHATKLSRTK 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9302	NP_609645.2	PDI_b_PDIR_N	24..131	CDD:239365
		PDI_a_PDIR	144..249	CDD:239295	34/104 (33%)
		PDI_a_PDIR	272..373	CDD:239295	49/169 (29%)
		PDI_a_PDIR	397..498	CDD:239295	37/170 (22%)
PDIA4	NP_001358173.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..58		2/2 (100%)
		pdi_dom	67..168	CDD:273454	32/112 (29%)
		CXXC. /evidence=ECO:0000250|UniProtKB:P08003	91..94		2/2 (100%)
		ER_PDI_fam	177..641	CDD:273457	94/465 (20%)
		CXXC. /evidence=ECO:0000250|UniProtKB:P08003	556..559		2/2 (100%)
		Prevents secretion from ER	643..646		0/1 (0%)