DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9302 and MPD1

DIOPT Version :9

Sequence 1:	NP_609645.2	Gene:	CG9302 / 34750	FlyBaseID:	FBgn0032514	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_014931.3	Gene:	MPD1 / 854462	SGDID:	S000005814	Length:	318	Species:	Saccharomyces cerevisiae

Alignment Length:	304	Identity:	76/304 - (25%)
Similarity:	111/304 - (36%)	Gaps:	101/304 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 WEEDPAGKDVLHFSDAA--SFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKASTELKTKGGYI 198
            ::.||      |.|:..  ||.|.:.......||.||.||||.|||:...:.||:..|  .|...
Yeast    25 YDSDP------HISELTPKSFDKAIHNTNYTSLVEFYAPWCGHCKKLSSTFRKAAKRL--DGVVQ 81

  Fly   199 LAAMNVERQENAPIRKMFNITGFPTLIYF-----------ENGKLRFT------YEGENNKEALV 246
            :||:|.:..:|..:...:::.|||||:.|           :|.|..|:      |.|......:|
Yeast    82 VAAVNCDLNKNKALCAKYDVNGFPTLMVFRPPKIDLSKPIDNAKKSFSAHANEVYSGARTLAPIV 146

  Fly   247 SFMLNPNAKPTPKPKEPEWSADTNSEIVHLTSQGFEPALKDEKSALVMF-----YAP-------- 298
            .|.|:.......|             .|.:.:.| ....|..|.::|:|     .:|
Yeast   147 DFSLSRIRSYVKK-------------FVRIDTLG-SLLRKSPKLSVVLFSKQDKISPVYKSIALD 197

  Fly   299 WCGHC-------KRMK------PEYEKAALEMK--QKKIP-------GLLAALDATKEPSIAEKY 341
            |.|..       |::|      |.|||.....|  ||.||       ..|...||.|:
Yeast   198 WLGKFDFYSISNKKLKQLTDMNPTYEKTPEIFKYLQKVIPEQRQSDKSKLVVFDADKD------- 255

  Fly   342 KVKGYPTVKFFSNGVFKFEVNVREASKIVEFMRD-----PKEPP 380
                    ||     :::|.|....:.|.:|:||     |.|.|
Yeast   256 --------KF-----WEYEGNSINKNDISKFLRDTFSITPNEGP 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9302	NP_609645.2	PDI_b_PDIR_N	24..131	CDD:239365
		PDI_a_PDIR	144..249	CDD:239295	36/123 (29%)
		ER_PDI_fam	166..500	CDD:273457	69/272 (25%)
		PDI_a_PDIR	272..373	CDD:239295	29/135 (21%)
		PDI_a_PDIR	397..498	CDD:239295
MPD1	NP_014931.3	ER_PDI_fam	30..>275	CDD:273457	69/280 (25%)
MPD1	NP_014931.3	PDI_a_MPD1_like	30..150	CDD:239300	37/121 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810