DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9302 and TXNDC16

DIOPT Version :9

Sequence 1:	NP_609645.2	Gene:	CG9302 / 34750	FlyBaseID:	FBgn0032514	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_065835.2	Gene:	TXNDC16 / 57544	HGNCID:	19965	Length:	825	Species:	Homo sapiens

Alignment Length:	330	Identity:	67/330 - (20%)
Similarity:	124/330 - (37%)	Gaps:	78/330 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VQDD-IAE--YKDFKKLL-----------------RTKNNVLALYVTSAKSAAAELKIFREAAEA 69
            |||| :||  ::|.|:.|                 ...::::..|......:.|.|:.:.:.|..
Human   371 VQDDEVAETVFRDRKRKLPLELTVELTEETFNATVMASDSIVLFYAGWQAVSMAFLQSYIDVAVK 435

  Fly    70 IRGTGTMLLLDCGQQDRKKLCKKLKVSPDPYAIKHYKDGDFHKDYDRQLSVSSMITFMRDPSGDL 134
            ::||.||||......|...:|.|..|:..| .||.||.|:....|...|....::.|::......
Human   436 LKGTSTMLLTRINCADWSDVCTKQNVTEFP-IIKMYKKGENPVSYAGMLGTEDLLKFIQLNRISY 499

  Fly   135 P--------WEEDPAG---KDVLHFSDAASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKAS 188
            |        .||..:|   ||::.:|..:            :|.:|    ....|..|.::.:|.
Human   500 PVNITSIQEAEEYLSGELYKDLILYSSVS------------VLGLF----SPTMKTAKEDFSEAG 548

  Fly   189 TELKTKGGYILAAMNVERQENAPIRKMFNITGFPTLIYFEN--GKLRFTYEGENNKEALVSFMLN 251
            ..||   ||::.  .:..:|:..:.........|.|:...:  ||:........:.:.:|..:.:
Human   549 NYLK---GYVIT--GIYSEEDVLLLSTKYAASLPALLLARHTEGKIESIPLASTHAQDIVQIITD 608

  Fly   252 PNAKPTPKPKEPEWSADTNSEIVHLTSQGFEPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALE 316
            ...:..|:                :|.:......:.:|..|::|      ....:.|:|:||.|.
Human   609 ALLEMFPE----------------ITVENLPSYFRLQKPLLILF------SDGTVNPQYKKAILT 651

  Fly   317 M-KQK 320
            : |||
Human   652 LVKQK 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9302	NP_609645.2	PDI_b_PDIR_N	24..131	CDD:239365	32/125 (26%)
		PDI_a_PDIR	144..249	CDD:239295	17/106 (16%)
		ER_PDI_fam	166..500	CDD:273457	28/158 (18%)
		PDI_a_PDIR	272..373	CDD:239295	12/50 (24%)
		PDI_a_PDIR	397..498	CDD:239295
TXNDC16	NP_065835.2	PDI_a_family	394..492	CDD:239259	22/98 (22%)
		Thioredoxin_6	533..722	CDD:290560	27/155 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	762..787
		Mediates endoplasmic reticulum retention. /evidence=ECO:0000269\|PubMed:25122923	816..819
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900