DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9302 and pdia5

DIOPT Version :9

Sequence 1:	NP_609645.2	Gene:	CG9302 / 34750	FlyBaseID:	FBgn0032514	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001107048.1	Gene:	pdia5 / 556162	ZFINID:	ZDB-GENE-030521-5	Length:	528	Species:	Danio rerio

Alignment Length:	508	Identity:	232/508 - (45%)
Similarity:	324/508 - (63%)	Gaps:	26/508 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FVFLLLVALVAAKS--KTSAVQDDIAEYKDFKKLLRTKNNVLALYVTSAKSAAAELKIFREAAEA 69
            |:||.|||:.:|..  |.|.:.:.:.::|||||||||:.|||.||..||.|..|.||:..:.|:|
Zfish    17 FIFLSLVAVTSALQAVKVSPLIEKVNDHKDFKKLLRTRTNVLVLYTKSASSGDAHLKLLSDVAQA 81

  Fly    70 IRGTGTMLLLDCGQQDRKKLCKKLKVSPDP----YAIKHYKDGDFHKDYDRQLSVSSMITFMRDP 130
            ::|.||:..::||..:.:|||||:||.|..    ..:.|||||.||.:|:|..:..||:.|::||
Zfish    82 VKGQGTIAWVNCGDSEGRKLCKKVKVDPSSKTKGVELLHYKDGTFHTEYNRPATFKSMVAFLKDP 146

  Fly   131 SGDLPWEEDPAGKDVLHFSDAASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKASTELKTKG 195
            :|...|||:|..|||:|......|.|.|:::.||:|:|||.||||.||:|:|.:.:|:||  |||
Zfish   147 AGAPLWEENPEAKDVVHIESEKDFRKLLKREERPILMMFYAPWCGVCKRMQPIFQQAATE--TKG 209

  Fly   196 GYILAAMNVERQENAPIRKMFNITGFPTLIYFENGKLRFTYE--GENNKEALVSFMLNPNAKPTP 258
            .|:||.|||...|...:::.|::.|:||..|||.||....||  |..:|: :..::.||.   .|
Zfish   210 KYVLAGMNVHPAEFDGVKQEFSVKGYPTFCYFEKGKFLHHYENYGATSKD-ITDWLKNPQ---PP 270

  Fly   259 KPKEPE--WSADTNSEIVHLTSQGFEPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALEM-KQK 320
            :||.||  || ::.|.:.|||...|:..|::..|||:|||||||||||:|||||:.||..: |..
Zfish   271 QPKTPEVPWS-ESGSAVFHLTDDSFDSFLEEHPSALIMFYAPWCGHCKKMKPEYDDAAETLNKDP 334

  Fly   321 KIPGLLAALDATKEPSIAEKYKVKGYPTVKFFSNGVFKFEV-NVREASKIVEFMRDPKEPPPPPP 384
            ..||:|||:|.|...|..|::|:.|:||||:|..|..|:.: ::|...||:|::   |.|..|||
Zfish   335 NSPGVLAAVDTTIHKSTGERFKISGFPTVKYFEKGEEKYTLPHLRSKDKIIEWL---KNPQAPPP 396

  Fly   385 PEKSWEEEEDSKEVLFLDDDNFSSTLKRKKHALVMFYAPWCGHCKHTKPEFTAAATALQDDPRIA 449
            |||||:|...|  |..|..::|..:||:|||||||||||||.|||:..|.||.||...::|.:||
Zfish   397 PEKSWDEMPSS--VSHLGAEDFRESLKKKKHALVMFYAPWCPHCKNAVPHFTTAAEMFKEDRKIA 459

  Fly   450 FVAIDCTK--LAALCAKYNVRGYPTILYFSYLKTKLDYNGGRTSKDFIAYMNN 500
            :.|:||||  ...||.:..|.||||..|::|.|....|||.|....|..:|.|
Zfish   460 YAAVDCTKGQNHELCKQEGVEGYPTFNYYNYGKFSEKYNGERGEAGFTGFMRN 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9302	NP_609645.2	PDI_b_PDIR_N	24..131	CDD:239365	48/110 (44%)
		PDI_a_PDIR	144..249	CDD:239295	46/106 (43%)
		ER_PDI_fam	166..500	CDD:273457	159/341 (47%)
		PDI_a_PDIR	272..373	CDD:239295	49/102 (48%)
		PDI_a_PDIR	397..498	CDD:239295	49/102 (48%)
pdia5	NP_001107048.1	PDI_b_PDIR_N	36..147	CDD:239365	48/110 (44%)
		PDI_a_PDIR	160..264	CDD:239295	46/106 (43%)
		ER_PDI_fam	181..512	CDD:273457	159/342 (46%)
		PDI_a_PDIR	285..388	CDD:239295	49/102 (48%)
		PDI_a_PDIR	407..510	CDD:239295	50/104 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170587956
Domainoid	1	1.000	136	1.000	Domainoid score	I4883
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4957
Inparanoid	1	1.050	453	1.000	Inparanoid score	I1571
OMA	1	1.010	-	-		QHG48073
OrthoDB	1	1.010	-	-		D237844at33208
OrthoFinder	1	1.000	-	-		FOG0006847
OrthoInspector	1	1.000	-	-		oto40774
orthoMCL	1	0.900	-	-		OOG6_108318
Panther	1	1.100	-	-	LDO	PTHR45672
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5488
SonicParanoid	1	1.000	-	-		X4936
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	16	15.840