DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9302 and pdia5

DIOPT Version :9

Sequence 1:	NP_609645.2	Gene:	CG9302 / 34750	FlyBaseID:	FBgn0032514	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001017340.1	Gene:	pdia5 / 550094	XenbaseID:	XB-GENE-6455315	Length:	525	Species:	Xenopus tropicalis

Alignment Length:	511	Identity:	227/511 - (44%)
Similarity:	327/511 - (63%)	Gaps:	22/511 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WITGQFVFLLLVALVAA---KSKTSAVQDDIAEYKDFKKLLRTKNNVLALYVTSAKSAAAELKIF 63
            |.....:.|||:.:..:   ..|.|.:.:.|.::|||||||||:||||.||..||.:|..:||..
Frog     9 WERKMLLSLLLLIICPSCLISIKISPLIEKIDDHKDFKKLLRTRNNVLVLYSKSASAAEQQLKFL 73

  Fly    64 REAAEAIRGTGTMLLLDCGQQDRKKLCKKLKVSPD--PYAIK--HYKDGDFHKDYDRQLSVSSMI 124
            ...|:.::|..|:..:|||..:.:||||||||.|.  |..::  |||||.||.:|:|..:..|:|
Frog    74 SNIAQDVKGRATVSWIDCGDAEGRKLCKKLKVDPSKKPNGVELLHYKDGTFHTEYNRPNTHKSLI 138

  Fly   125 TFMRDPSGDLPWEEDPAGKDVLHFSDAASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKAST 189
            .|::||.|...|||:|..|||:|..:...|.|.|:::.||:|:|||.||||.||::.|.|.:|:.
Frog   139 AFLKDPEGAPLWEENPDAKDVVHIDNEKDFRKFLKREDRPLLLMFYAPWCGVCKRLMPSYQQAAA 203

  Fly   190 ELKTKGGYILAAMNVERQENAPIRKMFNITGFPTLIYFENGKLRFTYE--GENNKEALVSFMLNP 252
            .|  ||.|:||.||:...|...:::.:::.|:||::|||.||..|.:|  |.:.:: :..::.||
Frog   204 NL--KGSYVLAGMNIHPPEFDRLKEEYSVKGYPTVLYFEKGKYMFNFEKYGASAQD-IADWLKNP 265

  Fly   253 NAKPTPKPKEPEWSADTNSEIVHLTSQGFEPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALEM 317
            .| |||:..|..|| :|::.:.|||...|:..|.:..|.|||||||||||||:|||:|||||..:
Frog   266 QA-PTPEAPEVAWS-ETDNPVYHLTDADFDQFLAEHPSVLVMFYAPWCGHCKKMKPDYEKAAETL 328

  Fly   318 KQKKIPGLLAALDATKEPSIAEKYKVKGYPTVKFFSNGVFKFEV-NVREASKIVEFMRDPKEPPP 381
            ..:...|:|||:|:|...:::||:||.|:||||:|.||..|:.| ::|...||||:|.:|:   .
Frog   329 HAESGAGVLAAVDSTVHRAVSEKFKVTGFPTVKYFENGEEKYTVPHLRTEQKIVEWMHNPE---A 390

  Fly   382 PPPPEKSWEEEEDSKEVLFLDDDNFSSTLKRKKHALVMFYAPWCGHCKHTKPEFTAAATALQDDP 446
            |||||.||:|:..|  ||.|..|.|...||:|||:|||||||||.|||.|.|:||.||...::|.
Frog   391 PPPPELSWDEKPSS--VLHLVGDEFREALKKKKHSLVMFYAPWCPHCKSTIPDFTTAADTFKEDR 453

  Fly   447 RIAFVAIDCT--KLAALCAKYNVRGYPTILYFSYLKTKLDYNGGRTSKDFIAYMNN 500
            :||:.|:|||  |...||.:..|.|:||...::|.|....|:|.||...||.::.:
Frog   454 KIAYGAVDCTKEKNQELCKQEGVEGFPTYNCYNYGKFSEKYSGERTESGFIGFVKS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9302	NP_609645.2	PDI_b_PDIR_N	24..131	CDD:239365	50/110 (45%)
		PDI_a_PDIR	144..249	CDD:239295	41/106 (39%)
		ER_PDI_fam	166..500	CDD:273457	156/338 (46%)
		PDI_a_PDIR	272..373	CDD:239295	52/101 (51%)
		PDI_a_PDIR	397..498	CDD:239295	50/102 (49%)
pdia5	NP_001017340.1	PDI_b_PDIR_N	34..145	CDD:239365	50/110 (45%)
		PTZ00102	151..507	CDD:240266	168/365 (46%)
		PDI_a_PDIR	158..262	CDD:239295	41/106 (39%)
		PDI_a_PDIR	284..385	CDD:239295	52/100 (52%)
		PDI_a_PDIR	404..506	CDD:239295	51/103 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5588
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	443	1.000	Inparanoid score	I1605
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006847
OrthoInspector	1	1.000	-	-		oto102702
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4936
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050