DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9302 and l(2)01289

DIOPT Version :9

Sequence 1:	NP_609645.2	Gene:	CG9302 / 34750	FlyBaseID:	FBgn0032514	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001163065.1	Gene:	l(2)01289 / 46017	FlyBaseID:	FBgn0010482	Length:	1786	Species:	Drosophila melanogaster

Alignment Length:	596	Identity:	117/596 - (19%)
Similarity:	207/596 - (34%)	Gaps:	192/596 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 VQDDIAEY-----KDFKKLLRTK----NNVLALYVTSAK--SAAAELKIFREAAEAIRGTGTMLL 78
            :.|:.|||     |...||:..|    |.....|....|  :...::....|..:.:.....|.:
  Fly  1060 IDDEAAEYGIYIVKMHDKLMAKKYGFRNPPGLTYFRKGKYINYDGDIDDEEEVLDWLTSPANMEM 1124

  Fly    79 LDCGQQDRKKLCKKLKVSPDPYAIKHYKDG-----------------------DFHKDYDRQL-- 118
            .|..:|..:|:.:|::.:.|..|:..|.|.                       ||.|..|:|:
  Fly  1125 TDHIEQVNRKMFEKIRKNSDYVAVIFYSDECKQCPRVLAEVEHIDDEADKAGIDFVKIDDKQMAK 1189

  Fly   119 -----SVSSMITF---MRDP---SGDLPWEE----------DPAGKDVLHFSDAASFTKHLRKDI 162
                 ::.:::.|   .::|   :|||..||          ||:| ||:...:..... ||.::.
  Fly  1190 EYGVFALPAIVFFKPTSKEPVIYAGDLYEEEQILTWLITQKDPSG-DVIEDLEGERLV-HLIEES 1252

  Fly   163 RPMLVMFYVPW----CGFCKK---MKPEYGKASTELKTKGGYILAAMNVERQ-----------EN 209
            ..:.|.|   |    |..|..   .|....|...:.:.:||...||.....:           |:
  Fly  1253 GSIAVYF---WNKTKCDICNSKAARKARLKKERDQHQQEGGAASAAAAFGSEADPSEAAAGGAED 1314

  Fly   210 AP-------------------------------------IRKMFNITG----------------- 220
            ||                                     :.::.||..
  Fly  1315 APAAGSEGDSPPASAAAPADASTGKQEDDADGCEQCTKVLEELENIDDDCDKHGITFVKTRDFSV 1379

  Fly   221 --------FPTLIYFENGKLRFTYEGENNKEALVSFMLNPNAKPTPKPKEPEW--SADTNSEIVH 275
                    :|.|:|||.| :...:|||.::|..|.                :|  :..|...|..
  Fly  1380 ADGYGVHEYPALVYFEGG-IPNVFEGELSEEEEVL----------------QWLITQKTEDRIEL 1427

  Fly   276 LTSQGFEPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALEMKQKKIPGLLAALDATKEPSIAEK 340
            :|.|..|..:::.:...|.||...|..|.::     ...||:...:.......:...::|.:|::
  Fly  1428 ITRQMLETMVEETQYLAVYFYKINCNICDQI-----LEGLELIDDECDVFGIHMVKIQDPQLAKR 1487

  Fly   341 YKVKGYPTVKFFSNG-VFKFEVNVREASKIVEFMRDPKEPPPPPPPEKSWEEEEDSKEV--LFLD 402
            |.:|.:|.:.:|.|| ...||.:::....::|::.|          :.:.|..::.:||  ..||
  Fly  1488 YSIKTFPALVYFRNGNPLLFEGDLQNEQSVLEWLID----------DDNRELADEIEEVNERMLD 1542

  Fly   403 DDNFSSTLKRKKHALVMFYAPWCGHCKHTKPEFTAAATALQDDPRIAFVAIDCTKLAALCA--KY 465
            .....|||     .:|.||...|..|:....|..      :.|.......||..|:|::.|  ||
  Fly  1543 RLMAESTL-----LVVFFYDDDCAECEEILEELE------EIDGEADMFGIDFVKIASIQAAKKY 1596

  Fly   466 NVRGYPTILYF 476
            .:...|:::||
  Fly  1597 EIVNIPSLVYF 1607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9302	NP_609645.2	PDI_b_PDIR_N	24..131	CDD:239365	28/152 (18%)
		PDI_a_PDIR	144..249	CDD:239295	31/184 (17%)
		ER_PDI_fam	166..500	CDD:273457	77/398 (19%)
		PDI_a_PDIR	272..373	CDD:239295	22/101 (22%)
		PDI_a_PDIR	397..498	CDD:239295	24/84 (29%)
l(2)01289	NP_001163065.1	PDI_a_family	50..145	CDD:239259
		PDI_a_family	384..479	CDD:239259
		Thioredoxin_6	510..689	CDD:404691
		ER_PDI_fam	700..>916	CDD:273457
		PDI_a_family	1129..1226	CDD:239259	19/96 (20%)
		TRX_family	1433..>1502	CDD:239245	14/73 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810