DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9302 and pdia8

DIOPT Version :9

Sequence 1:	NP_609645.2	Gene:	CG9302 / 34750	FlyBaseID:	FBgn0032514	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_001003517.1	Gene:	pdia8 / 445123	ZFINID:	ZDB-GENE-040801-20	Length:	493	Species:	Danio rerio

Alignment Length:	478	Identity:	120/478 - (25%)
Similarity:	184/478 - (38%)	Gaps:	140/478 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 DVLHFSDAASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKASTELKTKGGYILAAMNVERQE 208
            |||..:| |.| .:|..:...:||.||.||||.|||:.||:..|::.|  ||...||  .|:...
Zfish    26 DVLKLTD-ADF-DYLAPEHETLLVKFYAPWCGHCKKLAPEFESAASRL--KGTVTLA--KVDCTA 84

  Fly   209 NAPIRKMFNITGFPTLIYFENGKLRFTYEGENNKEALVSFMLNPNAKPTPKPKEPE--------- 264
            |..|.|.:.:.|:|||..|.||:...:|:|..:.:.:|.:| ...|.|.......|
Zfish    85 NTEICKHYGVNGYPTLKIFRNGQESSSYDGPRSADGIVDYM-KKQAGPDSVLLHSELDLEKFINH 148

  Fly   265 --------WSADTNSEIVH------LTSQGFEPALKDE----------KSALVMFYAPWCGHCKR 305
                    :|...:|::..      |..:.|..|...:          ..::::|.||      |
Zfish   149 FDASVVGLFSGTDSSQLAEFLKGASLMRESFRFAHTTDLQLGQKYGVTHESILLFRAP------R 207

  Fly   306 MKPEYEKAAL-------------------------------EMKQKKIPGLLAA---LDATKEPS 336
            :..::|::.:                               |:.:|:  .||.|   ||....|.
Zfish   208 LSSKFEESVVPHTGSLSVTGLRRFIRDNIFGLCPHMTKDNKEVLRKR--DLLTAYYDLDYLHNPK 270

  Fly   337 IAEKYKVKGYPTVKFFSNGVFKFEVNVREASKIVEFMR-----------DPKEPP-----PPPPP 385
            .:..::.:.......||:....|.|..|.     :||.           |..|.|     .....
Zfish   271 GSNYWRNRVLKVATKFSSQGMLFSVANRN-----DFMEELEEEFGLSASDGNELPFVTIRTRTGD 330

  Fly   386 EKSWEEE--EDSKEVLFLDDDNFSSTLKR------------------------------KKHALV 418
            :.|..||  .|.|.:....:|.|:..|||                              :|..|:
Zfish   331 KYSMREEFTRDGKSLESFLEDYFAGRLKRYVKSEPVPAINNGVVKVVVADTFEEIVNDPEKDVLI 395

  Fly   419 MFYAPWCGHCKHTKPEFTAAATALQDDPRIAFVAIDCTKLAALCAKYNVRGYPTILYFSYLKTKL 483
            .||||||||||..:|::||....|..||.|....:|.| :..:.|.|:|:|:||| ||:....|.
Zfish   396 EFYAPWCGHCKKLEPKYTALGEMLYSDPNIVIAKMDAT-VNDVPAGYDVQGFPTI-YFAAAGRKS 458

  Fly   484 D---YNGGRTSKDFIAYMNNPPT 503
            :   |.|.|..|||:.::....|
Zfish   459 EPKRYEGAREVKDFVNFLKREAT 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9302	NP_609645.2	PDI_b_PDIR_N	24..131	CDD:239365
		PDI_a_PDIR	144..249	CDD:239295	40/104 (38%)
		ER_PDI_fam	166..500	CDD:273457	112/451 (25%)
		PDI_a_PDIR	272..373	CDD:239295	21/150 (14%)
		PDI_a_PDIR	397..498	CDD:239295	42/133 (32%)
pdia8	NP_001003517.1	ER_PDI_fam	25..484	CDD:273457	120/478 (25%)
		pdi_dom	30..129	CDD:273454	38/105 (36%)
		PDI_b_ERp57	132..236	CDD:239367	11/109 (10%)
		PDI_b'_ERp72_ERp57	240..353	CDD:239371	24/119 (20%)
		PDI_a_PDI_a'_C	373..476	CDD:239293	37/104 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910