DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9302 and PDILT

DIOPT Version :9

Sequence 1:	NP_609645.2	Gene:	CG9302 / 34750	FlyBaseID:	FBgn0032514	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_777584.1	Gene:	PDILT / 204474	HGNCID:	27338	Length:	584	Species:	Homo sapiens

Alignment Length:	347	Identity:	73/347 - (21%)
Similarity:	136/347 - (39%)	Gaps:	50/347 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DDIAEY----KDFKKLLRTKNNVLALYVTSAKSAAAELKIFREAAEAIRGTGTMLLLDCGQQDRK 87
            |.:.||    ||....|...:::|.....|::|....::.::.|::..:.....:|:|..:....
Human   256 DFVIEYNTENKDLISELHIMSHMLLFVSKSSESYGIIIQHYKLASKEFQNKILFILVDADEPRNG 320

  Fly    88 KLCKKLKVS----PDPYAIKHYKDGDFHKDYDRQLSVSSMITFMR----------DPSGDLP--W 136
            ::.|..:|:    |....:....|..:....| .::..|:..|.|          ..|.::|  |
Human   321 RVFKYFRVTEVDIPSVQILNLSSDARYKMPSD-DITYESLKKFGRSFLSKNATKHQSSEEIPKYW 384

  Fly   137 EEDPAGKDVLHFSDAASFTKHLRKDIRPMLVMFYVPWCGFCKKMKPEYGKASTELKTKGGYILAA 201
            ::....:.|....:...|.|  .||:   .||||.||...||.:.|...:...:.:.....|:|.
Human   385 DQGLVKQLVGKNFNVVVFDK--EKDV---FVMFYAPWSKKCKMLFPLLEELGRKYQNHSTIIIAK 444

  Fly   202 MNVERQENAPIRKMFNITGFPTLIYFENGKLR-FTYEGENNKEALVSFMLNPNAKPTPKPKEPEW 265
            ::|...:   |:.|: :..:|....|.:|..: ..|:||:..:....| |..:.|...:.::...
Human   445 IDVTAND---IQLMY-LDRYPFFRLFPSGSQQAVLYKGEHTLKGFSDF-LESHIKTKIEDEDELL 504

  Fly   266 SADTNSEIVHLTSQGFEPALKDEKSALVMFYAPWCGHCKRMKPEYEKAALEMKQKKIPGL--LAA 328
            |.:.| |::.      |..|.:||...:|         ::..||.:...||...|.:..|  .|.
Human   505 SVEQN-EVIE------EEVLAEEKEVPMM---------RKGLPEQQSPELENMTKYVSKLEEPAG 553

  Fly   329 LDATKEPSIAEKYKVKGYPTVK 350
            ...|.|..:....|.||.|..|
Human   554 KKKTSEEVVVVVAKPKGPPVQK 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9302	NP_609645.2	PDI_b_PDIR_N	24..131	CDD:239365	20/121 (17%)
		PDI_a_PDIR	144..249	CDD:239295	25/105 (24%)
		ER_PDI_fam	166..500	CDD:273457	45/188 (24%)
		PDI_a_PDIR	272..373	CDD:239295	20/81 (25%)
		PDI_a_PDIR	397..498	CDD:239295
PDILT	NP_777584.1	YbbN	46..501	CDD:331940	51/255 (20%)
PDILT	NP_777584.1	Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	581..584
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0191
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810