Protein Alignment CG31729 and DNF1

DIOPT Version :10

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_011093.3
• Gene: DNF1 / 856913
• SGDID: S000000968
• Length: 1571
• Species: Saccharomyces cerevisiae
• Alignment Length: 1423
• Identity: 359/1423 - (25%)
• Similarity: 571/1423 - (40%)
• Gaps: 459/1423 - (32%)

  Fly   155 TGDLSNGA-THSTTVIDPENGSSTVFYQHNRR---KSKSRSIGNVCKLCLCSCWRKWF------- 208
            |..|:||: |.....:|.::|.....|...:|   .:|....||  .:...|...||.
Yeast    85 TPKLNNGSGTFDDVELDNDSGEPHTNYDGMKRFRMGTKRNKKGN--PIMGRSKTLKWARKNIPNP 147

  Fly   209 ---------------RPRELRARTVNL----GRVNTE-----KFPPNEIRNQKYNFITFLPLVLF 249
                           |.:|||....|:    ..::.|     ::|.|:||..||..:||||..:.
Yeast   148 FEDFTKDDIDPGAINRAQELRTVYYNMPLPKDMIDEEGNPIMQYPRNKIRTTKYTPLTFLPKNIL 212

  Fly   250 EQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQK- 313
            .||..|.|:|||::.:........:..|.....||..::::|..::|::|.||...|.|||:.|
Yeast   213 FQFHNFANVYFLVLIILGAFQIFGVTNPGLSAVPLVVIVIITAIKDAIEDSRRTVLDLEVNNTKT 277

  Fly   314 -------YKRLSSTNISGYEMV------------------------------------------- 328
                   .:.:|:.|||.:...
Yeast   278 HILEGVENENVSTDNISLWRRFKKANSRLLFKFIQYCKEHLTEEGKKKRMQRKRHELRVQKTVGT 342

  Fly   329 --PSSKL----------------------------------------------------KVGDVI 339
              |.|.|                                                    ||||::
Yeast   343 SGPRSSLDSIDSYRVSADYGRPSLDYDNLEQGAGEANIVDRSLPPRTDCKFAKNYWKGVKVGDIV 407

  Fly   340 IVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSELHSIDASFYVE 404
            .:..|:.:|||:|||.|||..|:.:|.|..|||||:.|.|.::..|..:....::  ....|::|
Yeast   408 RIHNNDEIPADIILLSTSDTDGACYVETKNLDGETNLKVRQSLKCTNTIRTSKDI--ARTKFWIE 470

  Fly   405 K--PQNDIHSFIATF---CMADGSEDT-----------GLSVENTLWANTVVAAGTATGIVIYTG 453
            .  |.::::::....   .:|||....           |.::.||.|         |.|:|::||
Yeast   471 SEGPHSNLYTYQGNMKWRNLADGEIRNEPITINNVLLRGCTLRNTKW---------AMGVVMFTG 526

  Fly   454 CETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLG--LSLVMMMLKGF-GGPWY------RYMF 509
            .:|:.::|:....:|...:..|:|      |..|:.  |..::..:.|. .|.:|      |:.:
Yeast   527 GDTKIMLNSGITPTKKSRISRELN------FSVVINFVLLFILCFVSGIANGVYYDKKGRSRFSY 585

  Fly   510 RF------------------VLLFSYIIPISLRVNLDMGK----AFYSWQMQNDSNIQGTVV--- 549
            .|                  |:|:..::||||.:::::.|    ||          |.|.|:
Yeast   586 EFGTIAGSAATNGFVSFWVAVILYQSLVPISLYISVEIIKTAQAAF----------IYGDVLLYN 640

  Fly   550 ---------RSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLS 605
                     :|..|.::||::.|:.:|||||||||.|.|||..:..||:..       ...:.|:
Yeast   641 AKLDYPCTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVSYGR-------AYTEALA 698

  Fly   606 GNILQQQQGSLSSSSSGG--------------DSTKPMMFGNRMRRPE--GWREWEAVR------ 648
            |  |:::|| :...:.|.              |..:.:. ||....||  .:...|.||
Yeast   699 G--LRKRQG-IDVETEGRREKAEIAKDRDTMIDELRALS-GNSQFYPEEVTFVSKEFVRDLKGAS 759

  Fly   649 -------------ALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQY 700
                         ||||||:|. |..:.||                         |...|    .
Yeast   760 GEVQQRCCEHFMLALALCHSVL-VEANPDN-------------------------PKKLD----L 794

  Fly   701 QAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIV 765
            :|.||||.|||.....||.:.:.:....:.::::      .|...::||.:..|.|..|||..||
Yeast   795 KAQSPDEAALVATARDVGFSFVGKTKKGLIIEMQ------GIQKEFEILNILEFNSSRKRMSCIV 853

  Fly   766 R-----ESKTGQITFYLKGADVVMSSIVQYNDWLSEESGN---------------MAREGLRTLV 810
            :     .....:.....||||.::.|      .||.:||:               .|.||||||.
Yeast   854 KIPGLNPGDEPRALLICKGADSIIYS------RLSRQSGSNSEAILEKTALHLEQYATEGLRTLC 912

  Fly   811 VAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLEL 875
            :|::.|:..:|..:..:|:.|..|:.:|..::..|.:|:||||.||..|.:|||||:.|...:||
Yeast   913 IAQRELSWSEYEKWNEKYDIAAASLANREDELEVVADSIERELILLGGTAIEDRLQDGVPDCIEL 977

  Fly   876 LRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQELNS------------ 928
            |..||:::|:|||||:|||..|..|..|:.....|.|   :||..|..:|..|
Yeast   978 LAEAGIKLWVLTGDKVETAINIGFSCNLLNNEMELLV---IKTTGDDVKEFGSEPSEIVDALLSK 1039

  Fly   929 ---------------FRRKQGH-------ALVISGESLEVCL--QYYRPEFLELATASPAVVCCR 969
                           |..|:.|       |:||.|::|::.|  :..|.:||.|.....||:|||
Yeast  1040 YLKEYFNLTGSEEEIFEAKKDHEFPKGNYAIVIDGDALKLALYGEDIRRKFLLLCKNCRAVLCCR 1104

  Fly   970 CSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHI 1034
            .||:|||.||.|::......|.|:|||.|||:|||.||.|:||.|.|||||.:..|::|.||.::
Yeast  1105 VSPSQKAAVVKLVKDSLDVMTLAIGDGSNDVAMIQSADVGIGIAGEEGRQAVMCSDYAIGQFRYL 1169

  Fly  1035 AKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFY--LSSVALYQGFLMVGYSTLYTMF 1097
            |:|:|:|||.||||.|.:.....::.:|...  |:|....|  .....||:...|:.|:..:|..
Yeast  1170 ARLVLVHGRWSYKRLAEMIPEFFYKNMIFAL--ALFWYGIYNDFDGSYLYEYTYMMFYNLAFTSL 1232

  Fly  1098 PVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILFVDEFI 1161
            ||..| :||||:....::..|:||:.....:..:.:.|..::|..:||.
Yeast  1233 PVIFLGILDQDVNDTISLVVPQLYRVGILRKEWNQRKFLWYMLDGLYQS---------------- 1281

  Fly  1162 HIVAISFSALIMTELIMVALTVRTWHRLMV-------LAELFSLALYLISLAV--------LHEY 1211
             |:...|..|:             :|:.|:       |...:.:.:|:.::||        ||:|
Yeast  1282 -IICFFFPYLV-------------YHKNMIVTSNGLGLDHRYFVGVYVTTIAVISCNTYVLLHQY 1332

  Fly  1212 -----------------FDWEFIW-----SYDF------------LWKVSLITLVSCL 1235
                             |.|..||     |.:|            .|.|..:.::.||
Yeast  1333 RWDWFSGLFIALSCLVVFAWTGIWSSAIASREFFKAAARIYGAPSFWAVFFVAVLFCL 1390

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	P-type_ATPase_APLT_Neo1-like	230..1177	CDD:319841	318/1204 (26%)
		Cation_ATPase	<704..781	CDD:463817	21/81 (26%)
DNF1	NP_011093.3	ATPase-Plipid	191..1413	CDD:273734	338/1315 (26%)