Protein Alignment CG31729 and NEO1

DIOPT Version :9

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_012216.1
• Gene: NEO1 / 854763
• SGDID: S000001310
• Length: 1151
• Species: Saccharomyces cerevisiae
• Alignment Length: 1227
• Identity: 523/1227 - (42%)
• Similarity: 746/1227 - (60%)
• Gaps: 135/1227 - (11%)

  Fly    70 NLFGSNSFGSAAGQIRYRNERSRERAK---HSNGSYSSISKLAQLTHTSSGVAGAGSIGGGGGGS 131
            |||.||:           |:.:.....   |.:.|:.:.....|:.:....::...::
Yeast    13 NLFNSNN-----------NQHANSVDSFDLHLDDSFDAALDSLQINNNPEPLSKHNTV------- 59

  Fly   132 GSATGIKVTTGDGSVAASGGSAATGDLSNGATHSTTVIDPENGSST-----VFYQH--------- 182
            |.....::.|.|             ||.|.:.||:   |....||.     :.|.:
Yeast    60 GDRESFEMRTVD-------------DLDNFSNHSS---DSHRKSSNTDTHPLMYDNRLSQDDNFK 108

  Fly   183 --NRRKSKSRSIGNV-------CKLCLCSCWRKWFRP---------RELRARTVNLGRVNTEKFP 229
              |...|...|..|:       .|:.....|.|:..|         ||:...|..:  .:..::.
Yeast   109 FTNIASSPPSSSNNIFSKALSYLKVSNTKNWSKFGSPIELSDQHIEREIHPDTTPV--YDRNRYV 171

  Fly   230 PNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICR 294
            .||:.|.|||.:||:|.:|:|||:||.|||||::||||.:|.:||||..:|..||.|||.||:.:
Yeast   172 SNELSNAKYNAVTFVPTLLYEQFKFFYNLYFLVVALSQAVPALRIGYLSSYIVPLAFVLTVTMAK 236

  Fly   295 EAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDR 359
            ||:||::|.:||.|.|::.|..::..     ..:||..|||||:|.|.|.:|:||||:||::|:.
Yeast   237 EAIDDIQRRRRDRESNNELYHVITRN-----RSIPSKDLKVGDLIKVHKGDRIPADLVLLQSSEP 296

  Fly   360 SGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSE 424
            ||..|::|||||||||||.|:|.|.||.||.:..::.|  |.....|:..||.|:......| |.
Yeast   297 SGESFIKTDQLDGETDWKLRVACPLTQNLSENDLINRI--SITASAPEKSIHKFLGKVTYKD-ST 358

  Fly   425 DTGLSVENTLWANTVVA-AGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVL 488
            ...|||:||||||||:| :|.....|:|||.:||..||.:..:.|.|||::|||.::|:|...|.
Yeast   359 SNPLSVDNTLWANTVLASSGFCIACVVYTGRDTRQAMNTTTAKVKTGLLELEINSISKILCACVF 423

  Fly   489 GLSLVMMMLKGF-GGPWYRYMFRFVLLFSYIIPISLRVNLDMGKAFYSWQMQNDSNIQGTVVRST 552
            .||::::...|| ...||..:.|:::|||.|||:|||||||:.|:.|:.|:::|..|..|:||::
Yeast   424 ALSILLVAFAGFHNDDWYIDILRYLILFSTIIPVSLRVNLDLAKSVYAHQIEHDKTIPETIVRTS 488

  Fly   553 TIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLS 617
            ||||:||||.|:|:|||||||||:|..||||||.||:.::|...:...:|.|    :..:..||:
Yeast   489 TIPEDLGRIEYLLSDKTGTLTQNDMQLKKIHLGTVSYTSETLDIVSDYVQSL----VSSKNDSLN 549

  Fly   618 SSSSGGDSTKPMMFGNRMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPT 682
            :|.....:|         |:...:|..:.:..||:||||||..:|:
Yeast   550 NSKVALSTT---------RKDMSFRVRDMILTLAICHNVTPTFEDD------------------- 586

  Fly   683 KSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQ 747
                          |..||||||||||:||:||.|||:|..||.::::|.    .|.:...|:|:
Yeast   587 --------------ELTYQAASPDEIAIVKFTESVGLSLFKRDRHSISLL----HEHSGKTLNYE 633

  Fly   748 ILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYNDWLSEESGNMAREGLRTLVVA 812
            |||:|||.|:|||||||||:.:..:..|..||||.|||.||:.||||.||:||||||||||||:.
Yeast   634 ILQVFPFNSDSKRMGIIVRDEQLDEYWFMQKGADTVMSKIVESNDWLEEETGNMAREGLRTLVIG 698

  Fly   813 KKVLTEEQYSDFETRYNAARLSITDRVAKVA-AVTESLERELELLCLTGVEDRLQENVRPTLELL 876
            :|.|.::.|..|:..||.|.||:.:|..::: .:|:.||.:||||.||||||:||::|:.::|||
Yeast   699 RKKLNKKIYEQFQKEYNDASLSMLNRDQQMSQVITKYLEHDLELLGLTGVEDKLQKDVKSSIELL 763

  Fly   877 RNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQELNSFRRKQGHALVISG 941
            ||||:::|||||||:|||.|::.|::||.|.|.:|.:..|.....|..:|...:..:...|:|.|
Yeast   764 RNAGIKIWMLTGDKVETARCVSISAKLISRGQYVHTITKVTRPEGAFNQLEYLKINRNACLLIDG 828

  Fly   942 ESLEVCLQYYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQA 1006
            |||.:.|::|..||.::....|.|:.|||:|.|||.|..:|:|.||||.|.:|||||||||||.|
Yeast   829 ESLGMFLKHYEQEFFDVVVHLPTVIACRCTPQQKADVALVIRKMTGKRVCCIGDGGNDVSMIQCA 893

  Fly  1007 DAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFS 1071
            |.||||.|:||:|||||.||||.||.|:.:|||.|||.||||||.|:|||:||||||...|||:|
Yeast   894 DVGVGIVGKEGKQASLAADFSITQFCHLTELLLWHGRNSYKRSAKLAQFVMHRGLIIAICQAVYS 958

  Fly  1072 AVFYLSSVALYQGFLMVGYSTLYTMFPVFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFI 1136
            .......:|||||:|||||:|.|||.|||||.||.||.......||||||:|::|:||||||||:
Yeast   959 ICSLFEPIALYQGWLMVGYATCYTMAPVFSLTLDHDIEESLTKIYPELYKELTEGKSLSYKTFFV 1023

  Fly  1137 WVLISIYQGGVIMY--GALILFVD-EFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSL 1198
            |||:|::||.||..  .|....:| :|..:|||||:||::.|||||||.:.||::.|::.|:.:|
Yeast  1024 WVLLSLFQGSVIQLFSQAFTSLLDTDFTRMVAISFTALVVNELIMVALEIYTWNKTMLVTEIATL 1088

  Fly  1199 ALYLISLAVLHEYFDWEFIWSYDFLWKVSLITLVSCLPLYIIKFLRKKCSPPSYLKL 1255
            ..|::|:..|.:|||..::.:.::...:.:|.|:|..|::..|.:.::..||||.|:
Yeast  1089 LFYIVSVPFLGDYFDLGYMTTVNYYAGLLVILLISIFPVWTAKAIYRRLHPPSYAKV 1145

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	29/51 (57%)
		ATPase-Plipid	228..1252	CDD:273734	488/1029 (47%)
		E1-E2_ATPase	323..525	CDD:278548	93/203 (46%)
		Cation_ATPase	<704..783	CDD:289987	41/78 (53%)
		HAD_like	<975..1019	CDD:304363	30/43 (70%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	116/230 (50%)
NEO1	NP_012216.1	P-type_ATPase_APLT_Neo1-like	172..1067	CDD:319841	464/952 (49%)
		Cation_ATPase	574..670	CDD:404183	54/132 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346106
Domainoid	1	1.000	251	1.000	Domainoid score	I339
eggNOG	1	0.900	-	-		E1_KOG0210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21915
Inparanoid	1	1.050	909	1.000	Inparanoid score	I40
Isobase	1	0.950	-	0	Normalized mean entropy	S481
OMA	1	1.010	-	-		QHG53737
OrthoFinder	1	1.000	-	-		FOG0002153
OrthoInspector	1	1.000	-	-		oto99782
orthoMCL	1	0.900	-	-		OOG6_101160
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5489
SonicParanoid	1	1.000	-	-		X1437
TreeFam	1	0.960	-	-
	16	15.740