Protein Alignment CG31729 and DNF2

DIOPT Version :10

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_010378.1
• Gene: DNF2 / 851667
• SGDID: S000002500
• Length: 1612
• Species: Saccharomyces cerevisiae
• Alignment Length: 1298
• Identity: 336/1298 - (25%)
• Similarity: 547/1298 - (42%)
• Gaps: 362/1298 - (27%)

  Fly   228 FPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTI 292
            :|.|:||..||..:||.|..:..||..|.|:|||::.:........:..|.....||..::::|.
Yeast   229 YPRNKIRTTKYTPLTFFPKNILFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITA 293

  Fly   293 CREAVDDLRRHQRDHEVNSQK-------------------YKRLSSTN----------------- 321
            .::.::|.||...|.|||:.:                   ::|....|
Yeast   294 IKDGIEDSRRTVLDLEVNNTRTHILSGVKNENVAVDNVSLWRRFKKANTRALIKIFEYFSENLTA 358

  Fly   322 -------------------------------ISGYEMV-----PS-------------------- 330
                                           |..|.|.     ||
Yeast   359 AGREKKLQKKREELRRKRNSRSFGPRGSLDSIGSYRMSADFGRPSLDYENLNQTMSQANRYNDGE 423

  Fly   331 --------------------SKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETD 375
                                ..:||||::.|..|:.:|||:|||.|||..|:.:|.|..|||||:
Yeast   424 NLVDRTLQPNPECRFAKDYWKNVKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETN 488

  Fly   376 WKPRLAVPYTQ--KLSRDSELHSIDASFYVEK--PQNDIHSFIATFCMADGSEDT---------- 426
            .|.|.::..::  |.|||    .....|:||.  |..:::|:...|...|.....
Yeast   489 LKVRQSLKCSKIIKSSRD----ITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPVNINN 549

  Fly   427 ----GLSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAV 487
                |.::.||.|         |.|:||:||.:|:.::|.....:|...:..|:|      |..:
Yeast   550 LLLRGCTLRNTKW---------AMGMVIFTGDDTKIMINAGVTPTKKSRISRELN------FSVI 599

  Fly   488 LGLSLVMMMLKGFG---GPWY------RYMFRF------------------VLLFSYIIPISLRV 525
            |...|:.::....|   |.:|      |..|.|                  |:|:..::||||.:
Yeast   600 LNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFVSFWVAVILYQSLVPISLYI 664

  Fly   526 NLDMGKAFYSWQMQNDSNIQGTVV------RSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHL 584
            ::::.|...:..:..|..:....:      :|..|.::||:|.|:.:|||||||||.|.|||..:
Yeast   665 SVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNVMEFKKCTI 729

  Fly   585 GIVSHD-ADTFHHIGQMIQKLSG------------NILQQQQGSLSSSSSGGDST----KPMMFG 632
            ..||:. |.|....|  ::|..|            .|.:.::..:....|..|:|    :.:.|.
Yeast   730 NGVSYGRAYTEALAG--LRKRQGVDVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFV 792

  Fly   633 NR-----MRRPEGWREWEA----VRALALCHN--VTPVSDDEDNRSVSTASTVTGGNNSPTKSVI 686
            ::     ::...|..:.:.    :.||||||:  |.|..||                  |.|..|
Yeast   793 SKEIVEDLKGSSGDHQQKCCEHFLLALALCHSVLVEPNKDD------------------PKKLDI 839

  Fly   687 NIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQL 751
                          :|.||||.|||....|:|.:.:....:.:.::::...::      :|:|.:
Yeast   840 --------------KAQSPDESALVSTARQLGYSFVGSSKSGLIVEIQGVQKE------FQVLNV 884

  Fly   752 FPFTSESKRMGIIVR--------ESKTGQITFYLKGADVVMSSIV---QYNDWLSEESG----NM 801
            ..|.|..|||..|::        |.|.   ....||||.|:.|.:   |.:..|.|::.    ..
Yeast   885 LEFNSSRKRMSCIIKIPGSTPKDEPKA---LLICKGADSVIYSRLDRTQNDATLLEKTALHLEEY 946

  Fly   802 AREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQ 866
            |.||||||.:|::.||..:|..:...|:.|..|:|:|..::..||:.:||||.||..|.:|||||
Yeast   947 ATEGLRTLCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAIEDRLQ 1011

  Fly   867 ENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGL------------------HVL 913
            :.|..::.||..||:::|:|||||:|||..|..|..::..:..|                  .|:
Yeast  1012 DGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELLVVKASGEDVEEFGSDPIQVV 1076

  Fly   914 RSVKTR--------TDAHQELNSFRRKQG-----HALVISGESLEVCL--QYYRPEFLELATASP 963
            .::.|:        :.:.:||...:|:.|     .|::|.|::|:|.|  :..|.:||.|.....
Yeast  1077 NNLVTKYLREKFGMSGSEEELKEAKREHGLPQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCK 1141

  Fly   964 AVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSI 1028
            ||:|||.||.|||.||.|::|.....|.|:|||.|||:|||.||.||||.|.|||||.:..|::|
Yeast  1142 AVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAI 1206

  Fly  1029 PQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGF-------- 1085
            .||.::.:|:|:||:..|||.|.:.....::.:|.|     .|..:|    .:|..|
Yeast  1207 GQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFT-----LSLFWY----GIYNNFDGSYLFEY 1262

  Fly  1086 -LMVGYSTLYTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLI-SIYQGGV 1147
             .:..|:..:|..||..| |||||::...::..|:||: :...|....:|.|:|.:: .:||..:
Yeast  1263 TYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYR-VGILRKEWNQTKFLWYMLDGVYQSVI 1326

  Fly  1148 IMYGALILFVDEFI-----------HIVAISFSALIMTEL-IMVALTVRTWHRLMVLAELFSLAL 1200
            ..:...:.:....:           :.|.:..:|:.:|.. ..|.:....|       :.|....
Yeast  1327 CFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTSCNFYVFMEQYRW-------DWFCGLF 1384

  Fly  1201 YLISLAVLHEYFDWEFIW-----SYDF------------LWKVSLITLVSC-LPLYIIKFLRK 1245
            ..:||||   ::.|..||     |.:|            .|.|..:.::.| ||.:.|..:||
Yeast  1385 ICLSLAV---FYGWTGIWTSSSSSNEFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRK 1444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	P-type_ATPase_APLT_Neo1-like	230..1177	CDD:319841	315/1208 (26%)
		Cation_ATPase	<704..781	CDD:463817	21/84 (25%)
DNF2	NP_010378.1	ATPase-Plipid	229..1456	CDD:273734	336/1298 (26%)