DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and DNF2

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_010378.1	Gene:	DNF2 / 851667	SGDID:	S000002500	Length:	1612	Species:	Saccharomyces cerevisiae

Alignment Length:	1298	Identity:	336/1298 - (25%)
Similarity:	547/1298 - (42%)	Gaps:	362/1298 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 FPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTI 292
            :|.|:||..||..:||.|..:..||..|.|:|||::.:........:..|.....||..::::|.
Yeast   229 YPRNKIRTTKYTPLTFFPKNILFQFHNFANIYFLILLILGAFQIFGVTNPGFASVPLIVIVIITA 293

  Fly   293 CREAVDDLRRHQRDHEVNSQK-------------------YKRLSSTN----------------- 321
            .::.::|.||...|.|||:.:                   ::|....|
Yeast   294 IKDGIEDSRRTVLDLEVNNTRTHILSGVKNENVAVDNVSLWRRFKKANTRALIKIFEYFSENLTA 358

  Fly   322 -------------------------------ISGYEMV-----PS-------------------- 330
                                           |..|.|.     ||
Yeast   359 AGREKKLQKKREELRRKRNSRSFGPRGSLDSIGSYRMSADFGRPSLDYENLNQTMSQANRYNDGE 423

  Fly   331 --------------------SKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETD 375
                                ..:||||::.|..|:.:|||:|||.|||..|:.:|.|..|||||:
Yeast   424 NLVDRTLQPNPECRFAKDYWKNVKVGDIVRVHNNDEIPADMILLSTSDVDGACYVETKNLDGETN 488

  Fly   376 WKPRLAVPYTQ--KLSRDSELHSIDASFYVEK--PQNDIHSFIATFCMADGSEDT---------- 426
            .|.|.::..::  |.|||    .....|:||.  |..:::|:...|...|.....
Yeast   489 LKVRQSLKCSKIIKSSRD----ITRTKFWVESEGPHANLYSYQGNFKWQDTQNGNIRNEPVNINN 549

  Fly   427 ----GLSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAV 487
                |.::.||.|         |.|:||:||.:|:.::|.....:|...:..|:|      |..:
Yeast   550 LLLRGCTLRNTKW---------AMGMVIFTGDDTKIMINAGVTPTKKSRISRELN------FSVI 599

  Fly   488 LGLSLVMMMLKGFG---GPWY------RYMFRF------------------VLLFSYIIPISLRV 525
            |...|:.::....|   |.:|      |..|.|                  |:|:..::||||.:
Yeast   600 LNFVLLFILCFTAGIVNGVYYKQKPRSRDYFEFGTIGGSASTNGFVSFWVAVILYQSLVPISLYI 664

  Fly   526 NLDMGKAFYSWQMQNDSNIQGTVV------RSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHL 584
            ::::.|...:..:..|..:....:      :|..|.::||:|.|:.:|||||||||.|.|||..:
Yeast   665 SVEIIKTAQAIFIYTDVLLYNAKLDYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNVMEFKKCTI 729

  Fly   585 GIVSHD-ADTFHHIGQMIQKLSG------------NILQQQQGSLSSSSSGGDST----KPMMFG 632
            ..||:. |.|....|  ::|..|            .|.:.::..:....|..|:|    :.:.|.
Yeast   730 NGVSYGRAYTEALAG--LRKRQGVDVESEGRREKEEIAKDRETMIDELRSMSDNTQFCPEDLTFV 792

  Fly   633 NR-----MRRPEGWREWEA----VRALALCHN--VTPVSDDEDNRSVSTASTVTGGNNSPTKSVI 686
            ::     ::...|..:.:.    :.||||||:  |.|..||                  |.|..|
Yeast   793 SKEIVEDLKGSSGDHQQKCCEHFLLALALCHSVLVEPNKDD------------------PKKLDI 839

  Fly   687 NIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQL 751
                          :|.||||.|||....|:|.:.:....:.:.::::...::      :|:|.:
Yeast   840 --------------KAQSPDESALVSTARQLGYSFVGSSKSGLIVEIQGVQKE------FQVLNV 884

  Fly   752 FPFTSESKRMGIIVR--------ESKTGQITFYLKGADVVMSSIV---QYNDWLSEESG----NM 801
            ..|.|..|||..|::        |.|.   ....||||.|:.|.:   |.:..|.|::.    ..
Yeast   885 LEFNSSRKRMSCIIKIPGSTPKDEPKA---LLICKGADSVIYSRLDRTQNDATLLEKTALHLEEY 946

  Fly   802 AREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQ 866
            |.||||||.:|::.||..:|..:...|:.|..|:|:|..::..||:.:||||.||..|.:|||||
Yeast   947 ATEGLRTLCLAQRELTWSEYERWVKTYDVAAASVTNREEELDKVTDVIERELILLGGTAIEDRLQ 1011

  Fly   867 ENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGL------------------HVL 913
            :.|..::.||..||:::|:|||||:|||..|..|..::..:..|                  .|:
Yeast  1012 DGVPDSIALLAEAGIKLWVLTGDKVETAINIGFSCNVLNNDMELLVVKASGEDVEEFGSDPIQVV 1076

  Fly   914 RSVKTR--------TDAHQELNSFRRKQG-----HALVISGESLEVCL--QYYRPEFLELATASP 963
            .::.|:        :.:.:||...:|:.|     .|::|.|::|:|.|  :..|.:||.|.....
Yeast  1077 NNLVTKYLREKFGMSGSEEELKEAKREHGLPQGNFAVIIDGDALKVALNGEEMRRKFLLLCKNCK 1141

  Fly   964 AVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSI 1028
            ||:|||.||.|||.||.|::|.....|.|:|||.|||:|||.||.||||.|.|||||.:..|::|
Yeast  1142 AVLCCRVSPAQKAAVVKLVKKTLDVMTLAIGDGSNDVAMIQSADVGVGIAGEEGRQAVMCSDYAI 1206

  Fly  1029 PQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGF-------- 1085
            .||.::.:|:|:||:..|||.|.:.....::.:|.|     .|..:|    .:|..|
Yeast  1207 GQFRYVTRLVLVHGKWCYKRLAEMIPQFFYKNVIFT-----LSLFWY----GIYNNFDGSYLFEY 1262

  Fly  1086 -LMVGYSTLYTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLI-SIYQGGV 1147
             .:..|:..:|..||..| |||||::...::..|:||: :...|....:|.|:|.:: .:||..:
Yeast  1263 TYLTFYNLAFTSVPVILLAVLDQDVSDTVSMLVPQLYR-VGILRKEWNQTKFLWYMLDGVYQSVI 1326

  Fly  1148 IMYGALILFVDEFI-----------HIVAISFSALIMTEL-IMVALTVRTWHRLMVLAELFSLAL 1200
            ..:...:.:....:           :.|.:..:|:.:|.. ..|.:....|       :.|....
Yeast  1327 CFFFPYLAYHKNMVVTENGLGLDHRYFVGVFVTAIAVTSCNFYVFMEQYRW-------DWFCGLF 1384

  Fly  1201 YLISLAVLHEYFDWEFIW-----SYDF------------LWKVSLITLVSC-LPLYIIKFLRK 1245
            ..:||||   ::.|..||     |.:|            .|.|..:.::.| ||.:.|..:||
Yeast  1385 ICLSLAV---FYGWTGIWTSSSSSNEFYKGAARVFAQPAYWAVLFVGVLFCLLPRFTIDCIRK 1444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	17/50 (34%)
		ATPase-Plipid	228..1252	CDD:273734	336/1298 (26%)
		E1-E2_ATPase	323..525	CDD:278548	70/291 (24%)
		Cation_ATPase	<704..783	CDD:289987	23/86 (27%)
		HAD_like	<975..1019	CDD:304363	26/43 (60%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	60/266 (23%)
DNF2	NP_010378.1	ATPase-Plipid	229..1456	CDD:273734	336/1298 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910