DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and DRS2

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_009376.2	Gene:	DRS2 / 851207	SGDID:	S000000024	Length:	1355	Species:	Saccharomyces cerevisiae

Alignment Length:	1291	Identity:	355/1291 - (27%)
Similarity:	585/1291 - (45%)	Gaps:	238/1291 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 NLFGSNSFGSAAGQIRYRNERSRERAKHSNGSYSSISKLAQLTHTSSGVAGAGSIGGGGGGSGSA 134
            |||.||:         :.::.|....:..:.:|...|..|        |...|.....|.|..:|
Yeast    75 NLFMSNN---------HDDQTSWNANRFDSDAYQPQSLRA--------VKPPGLFARFGNGLKNA 122

  Fly   135 TGIKVTTGDGSVAASGGSAAT-GDLSNGATHSTTVIDPEN--GSSTVFYQHNRRKSKSRSIGNVC 196
            ...|...|..|...:..:|.| .:|.:      ..:|..|  ....:|.::..||:...:.||
Yeast   123 FTFKRKKGPESFEMNHYNAVTNNELDD------NYLDSRNKFNIKILFNRYILRKNVGDAEGN-- 179

  Fly   197 KLCLCSCWRKWFRPRELRARTVNLGRVNTE-KFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYF 260
                          .|.|...:|....|:. .:..|.|...||||.||||..||::|..:.||:|
Yeast   180 --------------GEPRVIHINDSLANSSFGYSDNHISTTKYNFATFLPKFLFQEFSKYANLFF 230

  Fly   261 LLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGY 325
            |..:..|.:|.:.....||..|.|..||:|:..:|.::|::|...|.|:|:...:..|..:....
Yeast   231 LCTSAIQQVPHVSPTNRYTTIGTLLVVLIVSAMKECIEDIKRANSDKELNNSTAEIFSEAHDDFV 295

  Fly   326 EMVPSSK----LKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQ 386
            |     |    ::|||:|.|:..|.:|||.|:|.:|:..|..::.|..|||||:.|.:.:...|.
Yeast   296 E-----KRWIDIRVGDIIRVKSEEPIPADTIILSSSEPEGLCYIETANLDGETNLKIKQSRVETA 355

  Fly   387 KLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADG----SED----TGLSVENTLWANTVVAAG 443
            |......|.:::.....|:|.:.::::..|..:.|.    |.|    .|.::.||.|
Yeast   356 KFIDVKTLKNMNGKVVSEQPNSSLYTYEGTMTLNDRQIPLSPDQMILRGATLRNTAW-------- 412

  Fly   444 TATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLV--------------- 493
             ..|:||:||.||:.:.|.:....|...::..||.....||..::.|.|:
Yeast   413 -IFGLVIFTGHETKLLRNATATPIKRTAVEKIINRQIIALFTVLIVLILISSIGNVIMSTADAKH 476

  Fly   494 --MMMLKGF--GGPWYRYMFRFVLLFSYIIPISLRVNLDMGKAFYSWQMQNDSNI------QGTV 548
              .:.|:|.  .|.:::....|.:|||.::||||.|.:::.|.:.::.:.:|.::      ..||
Yeast   477 LSYLYLEGTNKAGLFFKDFLTFWILFSNLVPISLFVTVELIKYYQAFMIGSDLDLYYEKTDTPTV 541

  Fly   549 VRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQ 613
            ||::::.||||:|.|:.:|||||||:|.|.||.  ..|..|         ..|.|:.
Yeast   542 VRTSSLVEELGQIEYIFSDKTGTLTRNIMEFKS--CSIAGH---------CYIDKIP-------- 587

  Fly   614 GSLSSSSSGGDSTKPMMFGNRMRRPEGWREWEAVR-------------------ALALCHNVTPV 659
                     .|.|..:..|..:    |:|:::.::                   .||.||.|.|
Yeast   588 ---------EDKTATVEDGIEV----GYRKFDDLKKKLNDPSDEDSPIINDFLTLLATCHTVIP- 638

  Fly   660 SDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIAR 724
                                       ..::.||.    :||||||||.|||:....:|...|.|
Yeast   639 ---------------------------EFQSDGSI----KYQAASPDEGALVQGGADLGYKFIIR 672

  Fly   725 DLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVM----- 784
            ..|::|:.::...|:.:    ||:|.:..|.|..|||..|.| ...|.|..:.||||.|:
Yeast   673 KPNSVTVLLEETGEEKE----YQLLNICEFNSTRKRMSAIFR-FPDGSIKLFCKGADTVILERLD 732

  Fly   785 SSIVQYNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESL 849
            ....||.:.......:.|.||||||.:|.:.::|.:|.::.:.||.|..::.:|..|:......:
Yeast   733 DEANQYVEATMRHLEDYASEGLRTLCLAMRDISEGEYEEWNSIYNEAATTLDNRAEKLDEAANLI 797

  Fly   850 ERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLR 914
            |:.|.|:..|.:||:||:.|..|:..|:.||:::|:||||:.|||..|..|.:|:..:..|.::.
Yeast   798 EKNLILIGATAIEDKLQDGVPETIHTLQEAGIKIWVLTGDRQETAINIGMSCRLLSEDMNLLIIN 862

  Fly   915 SVKTRTDAH----QELNSFRRKQ--GH-----ALVISGESLEVCLQYYRPE----FLELATASPA 964
            . :||.|..    :::|:....|  .|     ||||.|:||...|:   ||    .|.:|....|
Yeast   863 E-ETRDDTERNLLEKINALNEHQLSTHDMNTLALVIDGKSLGFALE---PELEDYLLTVAKLCKA 923

  Fly   965 VVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIP 1029
            |:|||.||.|||.||.::::.:.....|:|||.|||||||.|..||||.|.||.||:.:.|.::.
Yeast   924 VICCRVSPLQKALVVKMVKRKSSSLLLAIGDGANDVSMIQAAHVGVGISGMEGMQAARSADIAVG 988

  Fly  1030 QFSHIAKLLLIHGRRSYKR--SAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYST 1092
            ||..:.||||:||..||:|  .|.|..|..:..|.:|....||:..|  |..::.:.:.|..|:.
Yeast   989 QFKFLKKLLLVHGSWSYQRISVAILYSFYKNTALYMTQFWYVFANAF--SGQSIMESWTMSFYNL 1051

  Fly  1093 LYTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILF 1156
            .:|::|.|.: |.||.::|.....||:|||...||:..|...|:.|::...:...::..|.::::
Yeast  1052 FFTVWPPFVIGVFDQFVSSRLLERYPQLYKLGQKGQFFSVYIFWGWIINGFFHSAIVFIGTILIY 1116

  Fly  1157 ------------VDEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLAVLH 1209
                        .|.:...|.:..:::|:. |...||....|.:..::|...||..:||...:..
Yeast  1117 RYGFALNMHGELADHWSWGVTVYTTSVIIV-LGKAALVTNQWTKFTLIAIPGSLLFWLIFFPIYA 1180

  Fly  1210 EYF-------DWEFIWSYDFLWKVSLITLVSCLPLYII------KFLRKKCSPPSY 1252
            ..|       ::..:..:.:...|..:||: .||::.:      |:.::...|.:|
Yeast  1181 SIFPHANISREYYGVVKHTYGSGVFWLTLI-VLPIFALVRDFLWKYYKRMYEPETY 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	19/51 (37%)
		ATPase-Plipid	228..1252	CDD:273734	323/1127 (29%)
		E1-E2_ATPase	323..525	CDD:278548	61/232 (26%)
		Cation_ATPase	<704..783	CDD:289987	29/78 (37%)
		HAD_like	<975..1019	CDD:304363	23/43 (53%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	60/255 (24%)
DRS2	NP_009376.2	ATPase-Plipid	198..1240	CDD:273734	324/1129 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920