DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31729 and ATP8B4

DIOPT Version :9

Sequence 1:NP_609634.1 Gene:CG31729 / 34736 FlyBaseID:FBgn0051729 Length:1256 Species:Drosophila melanogaster
Sequence 2:XP_011520348.1 Gene:ATP8B4 / 79895 HGNCID:13536 Length:1257 Species:Homo sapiens


Alignment Length:1271 Identity:371/1271 - (29%)
Similarity:564/1271 - (44%) Gaps:274/1271 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 GGSAATGDLSNGATHSTTVIDPENGSSTVFYQHNRRKSKSRSIGNVCKLCLCSCWRKWFRPRELR 214
            ||::.:|.:|.|  |   ::.|...|..:.:                      |..|..|..|  
Human    14 GGASVSGGISVG--H---LLRPGERSGIIMF----------------------CSEKKLREVE-- 49

  Fly   215 ARTVNLG-RVNTEKF--PPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGY 276
             |.|... |...|||  ..|.|...|||.:||||:.|||||:...|.|||.:.:.|.||:|....
Human    50 -RIVKANDREYNEKFQYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLCLLILQLIPEISSLT 113

  Fly   277 PYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIV 341
            .:|...||..|:.:|..::|.||..||:.|::||:::.:.|.::.:...:.:   .:||||:|.:
Human   114 WFTTIVPLVLVITMTAVKDATDDYFRHKSDNQVNNRQSEVLINSKLQNEKWM---NVKVGDIIKL 175

  Fly   342 EKNERVPADLILLRTSDRSGSVFVRTDQLDG----------------------------ETDWKP 378
            |.|:.|.|||:||.:|:..|..:|.|.:|||                            ||:.|.
Human   176 ENNQFVAADLLLLSSSEPHGLCYVETAELDGSLCCYKDVPWVECQLFGAQEALPTFLKQETNLKV 240

  Fly   379 RLAVPYTQKLSRD-SELHSIDASFYVEKPQNDIHSFIATFCMADGSED--------TGLSVENTL 434
            |.|:..|.:|..| |.|...|.....|.|.|.:..|:......|....        .|..:.||.
Human   241 RHALSVTSELGADISRLAGFDGIVVCEVPNNKLDKFMGILSWKDSKHSLNNEKIILRGCILRNTS 305

  Fly   435 WANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKG 499
            |         ..|:||:.|.:|:.:.|:.:.:.|...:|..:|.|...:|..::.|.:::.:...
Human   306 W---------CFGMVIFAGPDTKLMQNSGKTKFKRTSIDRLMNTLVLWIFGFLICLGIILAIGNS 361

  Fly   500 F-----GGPWYRYMF-----------RFVLLFSYII------PISLRVNLD---MGKAFY-SW-- 536
            .     |..:..::|           .|:..:||||      ||||.|:::   :|.::: :|  
Human   362 IWESQTGDQFRTFLFWNEGEKSSVFSGFLTFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDR 426

  Fly   537 QMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHL-----GIVSHDADTFHH 596
            :|.........|.|:||:.||||:|.|:.:|||||||||.|.||:..:     |.|..|.|....
Human   427 KMYYSRKAIPAVARTTTLNEELGQIEYIFSDKTGTLTQNIMTFKRCSINGRIYGEVHDDLDQKTE 491

  Fly   597 IGQMIQKLSGNILQQQQGS-------LSSSSSGGDSTKPMMFGNRMRRPEGWREWEAVRALALCH 654
            |.|..:.:..::..|....       |..|...||.                :..|.:|.|||||
Human   492 ITQEKEPVDFSVKSQADREFQFFDHHLMESIKMGDP----------------KVHEFLRLLALCH 540

  Fly   655 NVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGL 719
                              ||....||..:.:              ||..||||.|||......|.
Human   541 ------------------TVMSEENSAGELI--------------YQVQSPDEGALVTAARNFGF 573

  Fly   720 TLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVM 784
            ...:|...|:|:      |:...|:.||:|....|.:..|||.:|||..: |||..|.||||.::
Human   574 IFKSRTPETITI------EELGTLVTYQLLAFLDFNNTRKRMSVIVRNPE-GQIKLYSKGADTIL 631

  Fly   785 SS---------IVQYNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVA 840
            ..         :...:|.|||.:|    ||||||.:|.:.|.::.:.::......|..:..:|..
Human   632 FEKLHPSNEVLLSLTSDHLSEFAG----EGLRTLAIAYRDLDDKYFKEWHKMLEDANAATEERDE 692

  Fly   841 KVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETA-----CC---- 896
            ::|.:.|.:||:|.||..|.|||:|||.|..|:..|..|.:::|:|||||.|||     .|    
Human   693 RIAGLYEEIERDLMLLGATAVEDKLQEGVIETVTSLSLANIKIWVLTGDKQETAINIGYACNMLT 757

  Fly   897 --------------------IAKSSQ-LIGRNQGL---HVLRSVKTRTDAHQELNSFRRKQ---G 934
                                :.|:.| |.|:|:..   ||:...|.:.    ||:|...:.   .
Human   758 DDMNDVFVIAGNNAVEVREELRKAKQNLFGQNRNFSNGHVVCEKKQQL----ELDSIVEETITGD 818

  Fly   935 HALVISGESLEVCLQY-YRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGN 998
            :||:|:|.||...|:. .:.:.||||.....|:|||.:|.||||||.|::|:....|.|:|||.|
Human   819 YALIINGHSLAHALESDVKNDLLELACMCKTVICCRVTPLQKAQVVELVKKYRNAVTLAIGDGAN 883

  Fly   999 DVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLII 1063
            |||||:.|..||||.|:||.||.||.|:|..||.::.:|||:|||.||.|......:..::....
Human   884 DVSMIKSAHIGVGISGQEGLQAVLASDYSFAQFRYLQRLLLVHGRWSYFRMCKFLCYFFYKNFAF 948

  Fly  1064 TTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGR 1127
            |.:...|......|:..:|..:.:..::.:||..||.:: :.|||::.:.:|..|:|||......
Human   949 TLVHFWFGFFCGFSAQTVYDQWFITLFNIVYTSLPVLAMGIFDQDVSDQNSVDCPQLYKPGQLNL 1013

  Fly  1128 SLSYKTFFIWVLISIYQGGV---IMYGALILFVDEFIHIVA--ISFSALIMTELIMV-----ALT 1182
            ..:.:.|||.||..||...|   |.|||......|....:|  .||:..:.|.|::|     ||.
Human  1014 LFNKRKFFICVLHGIYTSLVLFFIPYGAFYNVAGEDGQHIADYQSFAVTMATSLVIVVSVQIALD 1078

  Fly  1183 VRTWHRLMVLAELFSLALYLISLAVLHE-----YFDWEFIW--------SYDFLWKVSLITLV-S 1233
            ...|..:..:....|:|:|...|..:|.     .|..:|.:        :...:|.|.|:|.| |
Human  1079 TSYWTFINHVFIWGSIAIYFSILFTMHSNGIFGIFPNQFPFVGNARHSLTQKCIWLVILLTTVAS 1143

  Fly  1234 CLPLYIIKFLR------------------KKCSPPS 1251
            .:|:...:||:                  ||..|||
Human  1144 VMPVVAFRFLKVDLYPTLSDQIRRWQKAQKKARPPS 1179

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31729NP_609634.1 PhoLip_ATPase_N 227..279 CDD:292826 24/53 (45%)
ATPase-Plipid 228..1252 CDD:273734 354/1192 (30%)
E1-E2_ATPase 323..525 CDD:278548 63/260 (24%)
Cation_ATPase <704..783 CDD:289987 31/78 (40%)
HAD_like <975..1019 CDD:304363 26/43 (60%)
PhoLip_ATPase_C 1021..1249 CDD:292829 71/270 (26%)
ATP8B4XP_011520348.1 PhoLip_ATPase_N 51..116 CDD:292826 27/64 (42%)
ATPase-Plipid 65..1167 CDD:273734 348/1176 (30%)
Cation_ATPase 538..634 CDD:289987 40/134 (30%)
HAD_like <875..906 CDD:304363 20/30 (67%)
PhoLip_ATPase_C 906..1160 CDD:292829 69/253 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144886
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.860

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