DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31729 and cyp46a1.1

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001027519.1	Gene:	cyp46a1.1 / 613111	XenbaseID:	XB-GENE-22069537	Length:	507	Species:	Xenopus tropicalis

Alignment Length:	397	Identity:	73/397 - (18%)
Similarity:	126/397 - (31%)	Gaps:	114/397 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 WGPLGFVLMVTIC-----------REAVDDLRRHQRDHEV--NSQKYKRLSSTNISGYEMVPSSK 332
            |..|..:.:..||           ....|.:....||..:  :|....||...|...|:......
Frog     9 WASLLLLALTLICFLLFCGYIQYIHMKYDHIPGPPRDGFIFGHSPTILRLMKNNKVVYDQYLDWV 73

  Fly   333 LKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSELHSI 397
            .|.|.|:.:....||    |:|.||......|:.:.:. .:.|...|:|..|..:......:...
Frog    74 QKYGPVVRINALHRV----IVLITSPEGVKEFLMSPKY-SKNDIYDRVATLYGMRFMGKGLVTDK 133

  Fly   398 DASFYVEKPQNDIHSFIATFCM--------------------ADGSEDTGLSVENTLWANTV--V 440
            |...:.::.:....:|..|:.|                    |||..||.:   :.|::...  |
Frog   134 DHDHWYKQRRIMDPAFSRTYLMDLMGPFNEKAEELMERLSEQADGKSDTEM---HNLFSRVTLDV 195

  Fly   441 AAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFGGPWY 505
            .|..|.|                          ||:|.|...|......:||||..:.....|
Frog   196 IAKVAFG--------------------------MELNSLKDDLTPLPQAISLVMNGIVETRNP-- 232

  Fly   506 RYMFRFVLL---FSYIIPISLRVNLDMGKAFY---SWQMQNDSNI---------QGTVVRSTTIP 555
              |.::.|.   |...:..|:|:....||...   ..|:|:...|         :|..:.....|
Frog   233 --MIKYSLAKRGFIRKVQESIRLLRQTGKECIERRQKQIQDGEEIPMDILTQILKGAALEEDCDP 295

  Fly   556 EEL--GRISYVLTDKTGTLTQNEMVFKKIHLG---------------------IVSH-DADTFHH 596
            |.|  ..:::.:..:  ..|.|::.|..:.||                     .:.| |....|:
Frog   296 ETLLDNFVTFFIAGQ--ETTANQLSFAVMELGRNPEILQKAQKEIDEVIGSRRFIEHEDLSKLHY 358

  Fly   597 IGQMIQK 603
            :.|::::
Frog   359 LSQVLKE 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826
		ATPase-Plipid	228..1252	CDD:273734	73/397 (18%)
		E1-E2_ATPase	323..525	CDD:278548	43/226 (19%)
		Cation_ATPase	<704..783	CDD:289987
		HAD_like	<975..1019	CDD:304363
		PhoLip_ATPase_C	1021..1249	CDD:292829
cyp46a1.1	NP_001027519.1	p450	40..491	CDD:306555	68/366 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165164409
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930