DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and atp8b1

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001025562.1	Gene:	atp8b1 / 594952	XenbaseID:	XB-GENE-490143	Length:	1250	Species:	Xenopus tropicalis

Alignment Length:	1222	Identity:	346/1222 - (28%)
Similarity:	567/1222 - (46%)	Gaps:	232/1222 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 DPENGSSTVFYQHNRRKSKSRSIGNVCKLCLCSCW------RKWFRPRELRARTVNLGRVNTEKF 228
            :||        |:.|.....:|...|.|.|   .|      |.::...|.:.:....  :...|:
Frog    39 EPE--------QNRRNVQAEQSREPVIKEC---TWQVKANDRNFYDQPEFKKKVFLC--LKKSKY 90

  Fly   229 PPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTIC 293
            ..|.|:..|||.|||||:.|:|||:...|.|||::.:.|.||.|......|...||..||.:|..
Frog    91 AGNAIKTYKYNPITFLPVNLYEQFKRAANAYFLVLLILQTIPQISTVTWSTTLIPLLLVLGITAI 155

  Fly   294 REAVDDLRRHQRDHEVNSQKYKRLSSTNISG-YEMVPSSKLKVGDVIIVEKNERVPADLILLRTS 357
            ::.|||:.||:.|:|:|:    |.|.....| ::......:.|||:|.:.|||.||||::||.:|
Frog   156 KDLVDDIARHKMDNEINN----RPSEVITDGRFKKTKWKHIHVGDIIRINKNEFVPADVLLLSSS 216

  Fly   358 DRSGSVFVRTDQLDGETDWKPRLAVPYTQK-LSRDSELHSIDASFYVEKPQNDIHSFIATFCM-- 419
            |.:...:|.|.:|||||:.|.::::..|.| |.::.:|...|.....|:|.|.:..|:.|...
Frog   217 DPNSLCYVETAELDGETNLKFKMSLEITDKLLQKEEQLAGFDGLVECEEPNNRLDKFVGTLFWRG 281

  Fly   420 ------ADGSEDTGLSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEING 478
                  ||.....|.:|.||.:.:         |:|::.|.:|:.:.|:.:.|.|...:|..:|.
Frog   282 NSFGLDADKILLRGCTVRNTEYCH---------GLVLFAGADTKIMRNSGKTRLKRTKIDYLMNY 337

  Fly   479 LTKVLF----CAVLGLSLVMMMLKGFGG----PWYRY--------------MFRFVLLFSYIIPI 521
            :...:|    .|..||::.....:...|    .||.|              .:.::::.:.::||
Frog   338 MVYTIFVLLILAAAGLAIGQTFWEAKLGAANVSWYLYDGNNYSPSYRGFLAFWGYIIVLNTMVPI 402

  Fly   522 SLRVNLD---MGKAFY-SWQMQNDSNIQGT--VVRSTTIPEELGRISYVLTDKTGTLTQNEMVFK 580
            ||.|:::   :|:::: :|.:|...:.:.|  ..|:||:.|:||:|.|:.:|||||||||.|.||
Frog   403 SLYVSVEVIRLGQSYFINWDLQMYFSPKDTPAKARTTTLNEQLGQIQYIFSDKTGTLTQNIMTFK 467

  Fly   581 KIHL-GIVSHDADTFHHIGQMIQ-KLSGNILQQQQGSLSSSSSGGDSTKPMMFGNRMRRPEGWRE 643
            |..: |....|.|.....||..| ..|.|.|.....:...:          ....::|..:....
Frog   468 KCTINGTTYGDDDDELKSGQTKQVDFSWNPLADPSFTFHDN----------YLIEQIRAGKDKDV 522

  Fly   644 WEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEI 708
            :|..:.|||||.|                                 ....||.|..||||||||.
Frog   523 YEFFKLLALCHTV---------------------------------MAEKTDGELIYQAASPDEG 554

  Fly   709 ALVKWTEQVGLTLIARDLNTMTL----QVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESK 769
            |||......|...::|..:|:|:    |.||          |::|.:..|.|:.|||.||||: .
Frog   555 ALVTAARNFGFVFLSRTQSTITISELGQEKT----------YEVLAILDFNSDRKRMSIIVRQ-P 608

  Fly   770 TGQITFYLKGADVVMSSIVQYNDWLSEESGN----MAREGLRTLVVAKKVLTEEQYSDFETRYNA 830
            .|:|..|.||||.|:...:..::.:.:::..    .|...||||.:..|.:.:..:.::..:|..
Frog   609 DGRIRLYCKGADTVIYERLHPDNPIKDQTQKALDIFANASLRTLCLCYKDINKGDFENWSKKYKQ 673

  Fly   831 ARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETAC 895
            |.::.::|...:..|.|::|.:|:||..|.:||:||::|..|:..|..|.:::|:|||||.|||.
Frog   674 ASVATSNRDEALDRVYEAIETDLKLLGATAIEDKLQDDVSGTIFNLARADIKIWVLTGDKKETAE 738

  Fly   896 CIAKSSQLI--------GRNQGLHVLRSVKTRTDAHQELNSFRRKQG---------------HAL 937
            .|..|.:|:        |.:..:|:      :|....:.|.....||               |||
Frog   739 NIGYSCKLLDDDTEILYGEDINVHL------QTRMENQRNQMSGNQGAQSNQSGAFLPTDKKHAL 797

  Fly   938 VISGESL-EVCLQ------------------------------YYRPE-----FLELATASPAVV 966
            :|:|..| |:.|:                              |...|     |::||....||:
Frog   798 IITGSWLNEILLEKKKRKKKRLKLKFPRTKEEKEQQLHEKLKAYALKEQRQRSFVDLACECSAVI 862

  Fly   967 CCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQF 1031
            |||.:|.|||.||.|::::....|.|:|||.|||:||:.|..||||.|:||.||.::.|:|..||
Frog   863 CCRVTPKQKAMVVDLVKRYKKAVTLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQF 927

  Fly  1032 SHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTM 1096
            .::.:|||:|||.||.|.....::..::....|.:...:|.....|:..:|:.:.:..|:.||:.
Frog   928 RYLQRLLLVHGRWSYIRMCKFLRYFFYKNFSFTLVHFWYSFFNGFSAQTVYEDWFITLYNVLYSS 992

  Fly  1097 FPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGV-------IMYGAL 1153
            .||..: :||||::.:.::.:|.||....|....:||.||    :|::.|.|       |.|||.
Frog   993 LPVLLVGLLDQDVSDKLSLAFPRLYVPGQKDLLFNYKKFF----LSLFHGIVTSLIIFFIPYGAF 1053

  Fly  1154 ILFV-------DEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYL-----ISLA 1206
            :|.:       .::......:.:||::|....:.|....|..:...:...|:|:|.     :..|
Frog  1054 LLTMGQDGEAPSDYQSFAVTTATALVITVNFQIGLDTSYWTFVNAFSIFGSIAIYFGIMFDLHSA 1118

  Fly  1207 VLHEYFDWEFIWS--------YDFLWKVSLITLVSC-LPLYIIKFLRKKCSP 1249
            .:|..|...||::        ..:||...::|:..| ||:..::||.|...|
Frog  1119 GIHVLFPSMFIFTGAAPNALRQPYLWLTIILTVAFCLLPIVALRFLAKTIWP 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	23/51 (45%)
		ATPase-Plipid	228..1252	CDD:273734	334/1158 (29%)
		E1-E2_ATPase	323..525	CDD:278548	61/233 (26%)
		Cation_ATPase	<704..783	CDD:289987	32/82 (39%)
		HAD_like	<975..1019	CDD:304363	23/43 (53%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	64/256 (25%)
atp8b1	NP_001025562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		4/20 (20%)
atp8b1	NP_001025562.1	P-type_ATPase_APLT_Dnf-like	92..1049	CDD:319770	306/1033 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930